4 cases with an identical neuromuscular disorder are presented. The disorder was characterized by slowly progressive weakness and wasting of the proximal muscles together with either ocular or bulbar symptoms, fatigability, positive tensilon test, myasthenic response on repetitive nerve stimulations, elevated serum creatine phosphokinase, and neuropathic and myopathic muscle pathology. All the patients showed a fairly good response to anti-ChE medications and steroid administration. Serum creatine phosphokinase levels returned to normal values after steroid therapy. Myasthenia, polymyositis or other neuromuscular disorders were discussed in the differential diagnosis.

Adult↗

PubMedDate not supplied

Biochemical study of different conditions of type 2C muscle fiber in rat.

Type 2C muscle fibers were histochemically and biochemically examined under three different conditions in rats: in the neonatal stage, after neonatal denervation and on regenerating process after bupivacaine-induced injury. On histochemical examination, soleus was found to contain up to 90% of type 2C fiber in every condition, whereas both gastrocnemius and extensor digitorum longus contained 40-70%. On biochemical analysis, triglyceride was the smallest and glycogen was the largest in amounts in neonatal muscles, triglyceride was the largest and glycogen was lowest in amount in neonatal denervated muscles, while both triglyceride and glycogen were low in amounts in bupivacaine-treated muscles. These results suggested that although histochemical characteristics are the same, significant differences in biochemical properties exist between type 2C fibers in these three different conditions.

Animals↗