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Biomedical subjects

N Wolosowicz

Publications and source records attributed to N Wolosowicz.

14 recordsLinked to original sources
PubMed1981

The effect of somatostatin on haemostasis in dogs.

The effect of somatostatin on haemostasis in the dogs was tested. The following data could be found: marked shortening of clotting time, decrease of platelet count, decrease of fibrinogen, level, an increase of plasma euglobulin fibrinolytic activity, prolongation of thrombin time and consumption of plasminogen. The obtained results indicate a biphasic haemostatic reaction, first hypercoagulability and then hypocoagulability. The presented results are briefly discussed with some remarks to clinical practice.

Animals↗
PubMed1977

The inhibitory effect of heparin on trypsinogen activation with enterokinase.

The effect of heparin on the activation of trypsinogen by enterokinase and on trypsin activity has been investigated. Proteolytic activity of trypsin has been determined using caseinolytic method. It has been found that heparin inhibits trypsinogen activation only when it is preincubated with proenzyme before introduction of enterokinase to the tested system. In these experimental conditions heparin in final concentrations from 1 to 20 U/ml exhibits inhibitory effect diminishing trypsinogen activation to about 65% initial activity and in higher concentrations only to 50%. Heparin introduced to the tested system simultaneously with enterokinase or to the active trypsin did not appear evident inhibitory effect.

Endopeptidases↗