Biomedical subjects
Publications and source records attributed to N Z Zaripov.
The results of surgical intervention with the use of laparostomy in 29 patients with diffuse purulent peritonitis at the terminal stage are presented. In 11 cases, laparostomy was performed during the first operation, in 18--for postoperative peritonitis. At the time of operations, laser radiation, gastrointestinal intubation were widely used.
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The impact of acute ileus on the contractility and sensitivity of small intestinal smooth muscle cells to acetylcholine and histamine, as well as possible recovery of smooth muscle cells after removal of 3-hour acute ileus were studied. The contractility of small intestinal smooth muscle cells and their sensitivity to the agonists decreased in proportion to the duration of acute ileus only in the strangulated portion of the bowel. Removal of 3-hour acute ileus resulted in a stepwise recovery of the contractility and sensitivity of small intestinal smooth muscle cells to the agonists in the adducting, strangulated, and abducting portions. It is suggested that in acute ileus, the structure of smooth muscle receptors undergo modification due to tissue homeostatic changes or to the direct action of cell destruction products on receptors.
Under analysis were results of surgical treatment of 4908 patients with diseases of organs of the abdominal cavity obtained during the period from 1985 till 1990. In 57 patients relaparotomy was caused by early postoperative commissural ileus. Late diagnosis of the main disease, technical and tactical errors during operations and at the early postoperative period were responsible for the appearance of the commissural ileus. Of special significance in getting better results of treatment of patients with this complication are: timely diagnosis (with contrast enterography), obligatory decompression and intubation of the gastrointestinal tract, valuable intensive therapy with the ultraviolet laser intravascular photomodification of blood.