[Double tumors in patients with a squamous cell carcinoma of the mucous membrane in the head and neck region].
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Adult↗
Biomedical subjects
N de Vries
Publications and source records attributed to N de Vries.
Patients with an acoustic neurinoma examined with a tilting room.
Patients with acoustic neurinomas do not usually show vertigo or spontaneous nystagmus, suggesting a gradual decrease of vestibular function with adequate compensation. Seventeen patients with acoustic neurinoma were examined to test their postural control. Examination in the tilting room showed a visual dominance in postural control with these patients irrespective of involvement of the central vestibular system. The subjective horizon was determined in addition to routine audiovestibular examination, to be informed about the compensation process. When routine audiovestibular examination points to an acoustic neurinoma, a pathological subjective horizon favours the diagnosis, although this is not mandatory. The combination of tilting room and stabilometry is superior in detecting visual dominance to the standard Romberg test.
Humans↗
Thymostimulin enhancement of T-cell infiltration into head and neck squamous cell carcinoma.
BACKGROUND: Head and neck squamous cell carcinoma (HNSCC) produces immunosuppressive low-molecular-mass factors (LMMFs) responsible for defects in the cell-mediated immune system. These defects include impaired monocyte chemotaxis and an impaired capability of dendritic cells (DC) to form cellular clusters. It has been shown previously that the immunomodulating drug thymostimulin (TP1) restores these defects in vitro. METHODS: An immunohistochemical study was performed on tumors of 18 patients with HNSCC who had preoperatively been treated with TP1 in one of three dosages (0.5 mg/kg, 1.0 mg/kg, 2.0 mg/kg body weight). Additionally, tumors of 4 patients who had been treated with a placebo and 12 patients who had not received any preoperative treatment were studied. A relative surface area of infiltration, meaning the percentage of stromal or epithelial tissue covered by infiltrating cells in histological sections, was calculated using an image analysis system (VIDAS RT) for CD3+ T-cells, CD14+/CD68+ monocytes/macrophages and L25+/CD1a+ dendritic cells for each tumor. RESULTS: A highly significant, denser T-cell infiltration into the stromal tissue area of tumors of patients who had been treated with TP1 when compared with tumors of non-TP1-treated patients was observed for all three dosages. None of the other tumor-infiltrating cell types was affected by TP1. In addition, a correlation was found between the tumor T-cell infiltration and capability of DCs in the peripheral blood to form clusters with T-cells. No correlation existed between CD3+ T-cell numbers in peripheral blood and T-cell infiltration into the tumor; nor were monocyte chemotactic functions in peripheral blood correlated with tumor infiltration by monocytes or monocyte-derived macrophages and DCs. CONCLUSIONS: Preoperative treatment of HNSCC patients with TP1 appears to strongly enhance tumor--T-cell infiltration. The number of tumor-infiltrating DCs was not affected by TP1, but a positive correlation between tumor--T-cell infiltration and DC clustering capability suggests that the functional status of DCs is important in improved cell-mediated immunity.
Adjuvants, Immunologic↗
Prevention of second primary cancers in head and neck cancer patients: new perspectives.
Not all head and neck cancer patients have the same chance to develop second primary cancers. New evidence suggests that it is possible to select high-risk patients. Other new developments in Europe are intensive screening, not only during initial work-up but also during follow-up, and chemoprevention of second primaries by retinol and n-acetyl-cystein.
Head and Neck Neoplasms↗
Immunoglobulin allotypes in head and neck cancer patients with multiple primary cancers.
Immunoglobulin allotypes G1m, G2m, G3m, A2m and Km were determined in patients with a single head and neck cancer and in head and neck cancer patients with multiple primary tumours. Frequencies were compared with those of healthy controls. In all 39 patients with multiple primary tumours studied, Km(1) was absent vs. 82% and 75% absence in healthy controls and patients with a single head and neck cancer, respectively. This difference is highly significant. We conclude that head and neck cancer patients lacking the Km(1) are susceptible to the development of new cancers, and therefore should be screened thoroughly for more tumours.
Head and Neck Neoplasms↗
Complications in sinus surgery and new classification proposal.
Complication overviews may lead to measures directed toward quality improvement and to better information for patients. When evaluating the rhinological literature from 1979 to 1999, a detailed comparison could not be made because of differences in reporting. With the advent of electronically stored medical data, events can be registered better than before. To be able to compile very diverse data from electronic dossiers into concise overviews for feedback, a simple general scale with broad categories is needed. These feedback overviews enable insight in the complication rates of different kinds of sinus surgery and monitoring of changing trends in sinus surgery. An example of a general classification based on severity is presented for use when electronically storing medical data. This scale varies from adverse events (grade A) to death (grade D). A consensus on categorization of complications is a prerequisite for a valid comparison with other clinics. To instigate a discussion about consensus, this classification is presented as an example. Our proposal is presented together with an overview of sinus surgery complications in recent literature for reference.
Humans↗