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Biomedical subjects

N van der Wal

Publications and source records attributed to N van der Wal.

10 recordsLinked to original sources

Morphometric study of pseudoepitheliomatous hyperplasia in granular cell tumors of the tongue.

Several reports have mentioned the possibility of misdiagnosing pseudoepitheliomatous hyperplasia (PEH) of the overlying mucosa of a granular cell tumor as a squamous cell carcinoma (SCC). Because of this, morphometry was applied to five granular cell tumors with PEH and five well-differentiated SCC of the tongue. In addition, ten normal tongues have been examined. The mean area, the mean perimeter and the mean diameter of the 50 largest squamous epithelial nuclei in 50 fields were found to be significantly larger in squamous cell carcinomas than in granular cell tumors and normal tongues. The shape factor of the nucleus and the mitotic activity appeared to be of no significant value in this respect.

Adolescent

Geographic stomatitis and psoriasis.

5 new cases of geographic stomatitis are presented and added to a review of 32 similar cases reported in the literature up to 1987. Furthermore, a series of 70 consecutive patients with psoriasis were examined for oral mucosal lesions. Based upon the findings of the literature and the results of the present study, there seems insufficient proof to consider geographic stomatitis an oral manifestation of psoriasis.

Adolescent

Psychological aspects of patients with burning mouth syndrome.

This article reports the results of a psychological questionnaire survey of 184 patients who have burning mouth syndrome. The results are compared with normative data obtained in the Netherlands. In general, it may be concluded that in a large number of patients with glossodynia, psychological aspects such as anxiety, depression, and neurotic tendencies are of great importance. However, it must be emphasized that this conclusion may not be interpreted as support for a psychogenic cause of the syndrome or for a strong psychological factor in the etiology of glossodynia.

Adult

Osteoma or chondroma of the tongue; a clinical and postmortem study.

The occurrence of an osteoma or chondroma in the soft tissues of the oral cavity is rather uncommon. This anomaly occurs mainly on the tongue. Less than 60 cases have been published in the literature. In the first part of this treatise, 2 other patients are described, a 61-year-old female with a chondroma on the dorsum of the tongue and a 31-year-old female with an osteoma in the foramen caecum area. In the second part, the result of a post mortem study of 130 adult human tongues is reported. Not a single case of bone or cartilage formation was encountered in the cadaver tongues. The possible development of an osteoma or chondroma in embryonic life is discussed.

Adult

Thyroglossal cysts in patients over 30 years of age.

8 patients over 30 years of age with a thyroglossal cyst, who had not been operated on before and who underwent excision of the cyst by a Sistrunk procedure, are described. In 8 additional patients, a wait-and-see policy was adopted. Follow-up data of these 16 patients are reported 1.5-14 years after their last visit to the hospital. There were no recurrences in the group of treated patients. In the group of untreated patients, the cyst remained unchanged in 1, decreased in size in 3 and disappeared completely in the remaining 4 patients. The present study indicates that removal of a thyroglossal cyst in patients over 30 years of age is not obligatory.

Adult

Candida albicans in median rhomboid glossitis. A postmortem study.

To investigate the possible rôle of Candida in median rhomboid glossitis, the presence of Candida was looked for both in the foramen cecum area and the lateral borders of 100 human cadaver tongues. Almost equal %s were found in both locations. Although extrapolation of findings from postmortem material to normal subjects is somewhat hazardous, the results seem to question the importance of Candida in the etiology of median rhomboid glossitis.

Adult

Lingual thyroid. A clinical and postmortem study.

3 patients with lingual thyroid are reported. In addition, 5 patients are described with hypothyroidism in whom functioning thyroid tissue was only present at the base of the tongue without any noticeable swelling. In a postmortem study of 120 tongues, not a single case of lingual thyroid was encountered. The preponderance of females among cases of congenital hypothyroidism and/or lingual thyroid is discussed.

Adult

Amyloidosis of the tongue: a clinical and postmortem study.

Based on the limited number of reports and our own experience, amyloid involvement of the oral tissues seems to be rather rare, the tongue apparently being the most favoured site. Three such patients have been described in the present treatise. All 3 patients proved to be suffering from multiple myeloma or its prestage. In a previous postmortem study, more than 35% overall incidence of amyloid involvement of the tongue has been reported. In our own postmortem study of 100 tongues not a single case of amyloidosis was encountered. This inconsistency can probably be explained by the different use of stains and their interpretation. Limited experience with immunohistochemical methods for subtyping amyloid has been presented.

Adult