"Masterpiece" copolymer sequences by targeted equilibrium-shifting
We describe an equilibrium model to determine whether a random population of dynamic copolymer sequences could be driven by molecular recognition to a subset of sequences that tightly bind a specific ligand. The model predicts that the population's mean binding constant can be shifted, but because of competitive binding, only to a limited degree (ca. 2 orders of magnitude larger than the original mean). True chemical evolution will require a mechanism for selection and amplification.
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