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Biomedical subjects

Nancy A Collop

Publications and source records attributed to Nancy A Collop.

9 recordsLinked to original sources
PubMed2006

Gender differences in sleep disorders.

PURPOSE OF REVIEW: To evaluate recent evidence regarding gender differences in sleep. RECENT FINDINGS: Women have better sleep quality compared with men, with longer sleep times, shorter sleep-onset latency and higher sleep efficiency. Despite this, women have more sleep-related complaints than men. The amount of slow-wave sleep decreases with age in men and women. Normal physiologic periods, including puberty, menstruation, pregnancy, and menopause, are associated with alterations in sleep patterns. Gender differences in normal sleep may underlie the observed differences in risk of sleep disorders. Studies of insomnia support a female predominance, with increased divergence of prevalence between men and women with older age. Recent findings for the gender differences in obstructive sleep apnea have focused on differences in local neuromuscular reflexes and central ventilatory control. Restless legs syndrome has a slight female predominance, whereas rapid eye movement sleep behavior disorder and Kleine-Levin syndrome are more common in men. SUMMARY: Gender differences in sleep become apparent after the onset of puberty. Menstrual cycles, pregnancy, and menopause can alter sleep architecture. Gender-related differences in sleep disorders, such as obstructive sleep apnea, insomnia, and restless legs syndrome, include differences in prevalence, pathophysiology, clinical presentation, and response to therapy.

Female↗
PubMed2005

Obstructive sleep apnea syndromes.

Complete or partial collapse of the upper airway during sleep has different effects on the human body ranging from noisy breathing (snoring) to significant cardiovascular sequelae as seen in obstructive sleep apnea (OSA). Snoring is very common in the adult population and has been associated with morbidity in epidemiological studies. A variety of treatments may be used for primary snoring (snoring without symptoms) but none are universally successful. The upper airway resistance syndrome is thought to occur when incomplete obstruction of the upper airway results in frequent disruptions in sleep. Whether it is a true "syndrome" or just one end of the continuum of OSA is unclear. Obstructive sleep apnea causes not only sleep disruption but oxygen desaturation. It has been associated with numerous cardiovascular sequelae, including hypertension (systemic and pulmonary), arrhythmias, and stroke. Nasal continuous positive airway pressure (CPAP) is the current treatment of choice, with lesser alternatives including oral appliances, surgery, and weight loss. Further study on outcomes is required to determine how aggressively to treat these syndromes.

Adult↗
PubMed2005

Obstructive sleep apnea: what does the cardiovascular physician need to know?

Obstructive sleep apnea (OSA) is a common disorder in adults. It is becoming increasingly recognized as a risk factor for cardiovascular diseases such as hypertension, pulmonary hypertension, myocardial infarction, and stroke. Knowing the pathophysiologic effects that occur during obstructive apnea assists in understanding how chronic complications and sequelae develop. OSA is also being recognized as associated with glucose intolerance and motor vehicle accidents. Polysomnography in a sleep laboratory remains the diagnostic method of choice. Treatment options are somewhat limited in scope, but nasal continuous positive airway pressure is the first line and has been shown to clearly improve many of the symptoms and sequelae of the syndrome. Cardiovascular physicians require a working knowledge of OSA and its complications, as many of the diseases they manage have shown links to this sleep disorder.

Cardiology↗
PubMed2004

Gender differences in sleep and sleep-disordered breathing.

Sleep and sleep disorders are different in several important ways between men and women. Because of pregnancy and menopause, women experience changes in sleep that may present as clinical problems. In clinical populations, women are more likely to present with insomnia than are men, although their sleep may be better preserved. The presentation of sleep apnea in women is distinct from that of men and is less likely to include a "classic" history of witnessed ap-nea or heavy snoring. More likely it presents with nonspecific symptoms, such as fatigue or mood disturbance. There are little data on the effects of different treatments for OSA between men and women. OHS is a syndrome that may be as common in women as in men. The role of hormones in its pathophysiology is not well-defined.

Female↗
PubMed2002

Scoring variability between polysomnography technologists in different sleep laboratories.

OBJECTIVE: Examine the variability of polysomnography technologists from different sleep laboratories regarding scoring of polysomnograms. BACKGROUND: Polysomnography is the gold standard to diagnose obstructive sleep apnea-hypopnea syndrome. There are criteria to score sleep stages and respiratory events. We sought to determine how different technologists would score the same tests using their laboratory's criteria. METHODS: Eleven technologists in nine different sleep laboratories which used the Oxford Medilog SAC system scored eleven sleep studies performed in the Medical University of South Carolina Sleep Disorders Laboratory utilizing their respective laboratory's scoring rules. All sleep studies were performed for evaluation of obstructive sleep apnea-hypopnea syndrome (OSAHS). The scored studies were returned and analyzed for variability. RESULTS: Significant variability was present in scoring of both sleep and respiratory events with more variability demonstrated in respiratory event scoring. In four of the studies, diagnoses based on apnea-hypopnea indices (AHI) varied from none to moderate OSAHS depending on which technologist scored the study and in one study the diagnosis varied from none to severe OSAHS. CONCLUSIONS: Clinicians should be aware that there is tremendous variability among polysomnography technologists regarding the scoring of polysomnograms. These differences are likely due to different rules used to score events as well as differences in the technologist's interpretation of the rules.

Journal Article↗