Biomedical subjects

Nancy Beaudet

Publications and source records attributed to Nancy Beaudet.

2 recordsLinked to original sources

PubMedDate not supplied

Predicting children's blood lead levels from exposure to school drinking water in Seattle, Washington, USA.

OBJECTIVE: Lead exposure through drinking water is of increasing interest with little known about its potential childhood health impact. In 2004, school testing in Seattle, Washington, found lead concentrations in drinking water that exceeded national guidelines (>20 ppb). On the basis of these data, we estimated potential blood lead levels (BLLs) in elementary school children to better understand the potential health risks posed by these exposures. METHODS: We used the US Environmental Protection Agency Integrated Uptake Biokinetic Model for Lead in Children to predict geometric mean BLLs. We modeled typical-case and worst-case scenarios for children in 71 elementary schools on the basis of drinking water lead concentrations results from 2004. RESULTS: The estimated geometric mean BLLs under a typical scenario for each school ranged from 1.6 to 2.5 microg/dL. The worst-case scenario predicted geometric mean BLLs ranging from 1.7 to 5.0 microg/dL. All modeling yielded predicted BLLs well below the Centers for Disease Control and Prevention's public health goal of <10 microg/dL. CONCLUSIONS: Our modeling suggests drinking water exposures up to 10-15 times the Environmental Protection Agency guideline are unlikely to result in BLLs exceeding the current guidelines of the Centers for Disease Control and Prevention in the absence of other significant exposure sources. In Seattle, elevated school drinking water lead concentrations are not a significant source of lead exposure in school-age children. Further characterization of drinking water impacts are merited only if younger-age children are consuming water or if water lead concentrations are higher than those in this study.

Child↗

PubMedDate not supplied

Crab allergen exposures aboard five crab-processing vessels.

Aerosolized crab allergens are suspected etiologic agents for asthma among crab-processing workers. The objectives of this study were to characterize crab allergen concentrations and respiratory symptom prevalence among processing workers aboard crab-processing vessels. A cross-sectional survey of five crab-processing vessels was conducted near Dutch Harbor, Alaska. Crab allergen concentrations were quantified during specific work activities with 25 personal air samples collected on polytetrafluoroethylene filters and analyzed by a competitive IgE immunoassay technique. Two standardized respiratory questionnaires were used to assess respiratory symptoms suggestive of bronchitis or asthma in 82 workers. Aerosolized crab allergen concentrations ranged from 79 ng/m3 to 21,093 ng/m3 (mean = 2797 ng/m3, SD = 4576 ng/m3). The highest concentrations were measured at butchering/degilling work stations, which were combined on the smallest vessel. A significant percentage of workers reported development of respiratory symptoms during the crab-processing season. Cough developed in 28% of workers, phlegm in 11% of workers, and wheeze and other asthma-like symptoms developed in 4% of workers. Despite variations in crab allergen levels, respiratory symptom prevalence was similar across all job categories. Substantial concentrations of crab allergen exposure were measured, as well as the potential for wide variability in exposure during crab processing aboard vessels. The high prevalence of reported respiratory symptoms across all job categories suggests potential adverse respiratory effects that should be further characterized by prospective studies using pulmonary function and serology testing, and rigorous exposure characterization.

Adult↗