PubMed Health⌕ Search

Biomedical subjects

Nannan Cao

Publications and source records attributed to Nannan Cao.

2 recordsLinked to original sources

Estimating parametric line-source models with electroencephalography.

We develop three parametric models for electroencephalography (EEG) to estimate current sources that are spatially distributed on a line. We assume a realistic head model and solve the EEG forward problem using the boundary element method (BEM). We present the models with increasing degrees of freedom, provide the forward solutions, and derive the maximum-likelihood estimates as well as Cramér-Rao bounds of the unknown source parameters. A series of experiments are conducted to evaluate the applicability of the proposed models. We use numerical examples to demonstrate the usefulness of our line-source models in estimating extended sources. We also apply our models to the real EEG data of N20 response that is known to have an extended source. We observe that the line-source models explain the N20 measurements better than the dipole model.

Action Potentials↗

Parametric surface-source modeling and estimation with electroencephalography.

Electroencephalography (EEG) is an important tool for studying the brain functions and is becoming popular in clinical practice. In this paper, we develop four parametric EEG models to estimate current sources that are spatially distributed on a surface. Our models approximate the source shape and extent explicitly and can be applied to localize extended sources which are often encountered, e.g., in epilepsy diagnosis. We assume a realistic head model and solve the EEG forward problem using the boundary element method. We present the source models with increasing degrees of freedom, provide the forward solutions, and derive the maximum-likelihood estimates as well as Cramér-Rao bounds of the unknown source parameters. In order to evaluate the applicability of the proposed models, we first compare their estimation performances with the dipole model's using several known source distributions. We then discuss the conditions under which we can distinguish between the proposed extended sources and the focal dipole using the generalized likelihood ratio test. We also apply our models to the electric measurements obtained from a phantom body in which an extended electric source is imbedded. We observe that the proposed model can capture the source extent information satisfactorily and the localization accuracy is better than the dipole model.

Action Potentials↗