[Immunologic tests: C3 receptor (CR1, 2)].
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Biomedical subjects
Naoki Okuda
Publications and source records attributed to Naoki Okuda.
Microalbuminuria and cardiovascular events in elderly hypertensive patients without previous cardiovascular complications.
To assist in the development of better treatments for elderly hypertensive patients, we studied the degree to which the baseline values of urinary albumin excretion (UAE) and other cardiovascular risk factors were predictive of cardiovascular complications in a cohort of elderly hypertensive patients. In 1994, we adopted 144 elderly hypertensive patients, who had been treated for more than 6 years at various clinics and more than 1 year at the National Cardiovascular Center, Osaka, Japan. They were divided into 2 groups: a NA group (n=111) with normoalbuminuria (UAE<30mg/day) and an MA group (n=33) with microalbuminuria (UAE 30-300 mg/day). At baseline, the two groups were similar with respect to systolic and diastolic blood pressure (SBP/DBP), pulse pressure (PP), age, ratio of males to females, serum creatinine, uric acid, total cholesterol, fasting plasma glucose (FPG), and creatinine clearance (CCr). PP was calculated as SBP minus DBP. The efficacy of blood pressure (BP) control was similar in both groups during the 8-year follow up period; however, a total of 14 cardiovascular events occurred in the MA (6/33) and NA (8/111) groups, with the MA group showing the higher incidence rate by multiple logistic regression analysis (p<0.05). At 8 years of follow-up, PP and age were correlated with UAE (p<0.05, p<0.001). At the same time point, CCr was correlated with UAE at baseline (p<0.05). The results indicated that, in elderly hypertensive patients without previous cardiovascular complications, microalbuminuria can be a predictor of cardiovascular events irrespective of conventional BP control.
Aged↗
Relationship between home blood pressure and longitudinal changes in target organ damage in treated hypertensive patients.
Cross-sectional studies have shown that home blood pressure (BP) correlates with hypertensive target organ damage better than clinic BP. However, there have been few longitudinal studies regarding the predictive value of home BP on the changes in organ damage in treated hypertensive patients. Clinic and home BP over a 12-month period, antihypertensive medication use, echocardiographic and electrocardiographic results, and serum creatinine and urinary protein levels were examined in 209 treated hypertensive patients in 1993. These patients were prospectively followed for 5 years. The patients were divided into 4 subgroups according to hypertension control as follows: good control (<140/90 mmHg for clinic BP, <135/85 mmHg for home BP), improved, worsened, and poor control. The average clinic BP was 147.0+/-14.9/87.0+/-7.6 mmHg (mean+/-SD) in 1993 and 146.0+/-13.7/84.1+/-7.5 mmHg in 1998. The average home BP was 136.8+/-10.4/84.3+/-7.6 mmHg in 1993 and 136.1+/-9.7/81.2+/-7.7 mmHg in 1998. The left ventricular mass index (LVMI) positively correlated with both home systolic BP and clinic systolic BP in 1998 but not in 1993. The correlation tended to be closer for home BP than for clinic BP. LVMI did not change in patients with good or improved home systolic BP, while it increased in those with poor or worsened home systolic BP. The relationship between changes in LVMI and clinic BP was not significant. In conclusion, Home BP was more effective than clinic BP as a predictor of changes in left ventricular hypertrophy in treated hypertensive patients. Home BP should be controlled to below 135/85 mmHg to prevent cardiac hypertrophy.
Adult↗