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Nathan Sharon

Publications and source records attributed to Nathan Sharon.

23 records · Page 2Linked to original sources
PubMed2002

Inhibition of Helicobacter pylori adhesion to human gastric mucus by a high-molecular-weight constituent of cranberry juice.

A high-molecular-weight constituent of cranberry juice has been found to inhibit the sialyllactose specific adhesion of Helicobacter pylori strains to immobilized human mucus, erythrocytes, and cultured gastric epithelial cells. Different isolates of H. pylori differ in their affinity to the cranberry juice constituent. Cranberry juice may also inhibit adhesion of bacteria to the stomach in vivo, and may prove useful for the prevention of stomach ulcer that is caused by H. pylori.

Bacterial Adhesion↗
PubMed2002

Inhibitory effect of a high-molecular-weight constituent of cranberry on adhesion of oral bacteria.

A high-molecular-weight nondialysable material (NDM) isolated from cranberry juice at a concentration of 0.6 to 2.5 mg/ml dissociated coaggregates formed by many intergeneric oral bacteria. A lower concentration of NDM was required to inhibit formation of such coaggregates. NDM acted preferentially on pairs of oral bacteria in which one or both members are Gram-negative anaerobes. The high-molecular-weight material from blueberry also inhibited the coaggregation, although its activity was weaker, whereas such materials obtained from other fruits were inactive. Saliva did not interfere with the ability of NDM to inhibit coaggregation. A preliminary clinical trial showed that NDM reduces S. mutans counts in saliva. The antiadhesion activity of cranberry juice has a potential for altering the oral microbial flora resulting in improved oral hygiene.

Bacterial Adhesion↗