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Biomedical subjects

Nazan Tomac

Publications and source records attributed to Nazan Tomac.

7 recordsLinked to original sources
PubMed2005

Prevalence of obstructive sleep apnea syndrome and associated symptoms in 3--11-year-old Turkish children.

Our objective was to investigate the prevalence of sleep-disordered breathing (SDB) and obstructive sleep apnea syndrome (OSAS) in 3-11-year-old Turkish children. A cross-sectional study was conducted in Zonguldak, northwestern Turkey. Symptomatic children were identified by using a self-administered questionnaire and were classified into three groups: nonsnorers, occasional snorers, and habitual snorers. All habitual snoring children were invited to undergo polysomnography (PSG). Nine hundred fifty-four children (79.5%) were nonsnorers, 205 (17.2%) were occasional snorers, and 39 (3.3%) were habitual snorers. There was no significant relationship between gender and habitual snoring (male, 3.4%; female, 3.1%; P > 0.05; odds ratio (OR), 1.13; 95% confidence interval (CI), 0.59-2.14). There was a statistically significant relationship between habitual snoring and allergic rhinitis (OR, 4.23; 95% CI, 2.14-8.35). Four children who snored every night, and who had apnea spells and/or troubled sleep, underwent adenoidectomy and/or tonsillectomy before polysomnographic evaluation because of clinical detoriation. Twenty-eight of 39 children with habitual snoring participated in PSG evaluation. PSG revealed that 11 children (0.9% of the total population) had OSAS. When 4 operated children were added to these 28 children, we found the minimum prevalence of OSAS to be 1.3% in our study group. There was a significant correlation between OSAS and troubled sleeping (P <0.001; OR, 4.37; 95% CI, 1.33-14.3). We found the prevalence of habitual snoring to be 3.3% in Turkish children by using self-administered questionnaires. Allergic rhinitis was significantly correlated with habitual snoring. Minimum estimated prevalence of OSAS was found to be 1.3%.

Age Distribution↗
PubMed2004

The Ala-9Val polymorphism in the mitochondrial targeting sequence (MTS) of the manganese superoxide dismutase gene is not associated with juvenile-onset asthma.

BACKGROUND: We aimed to investigate the possible association between Mn-SOD polymorphism in the mitochondrial targeting sequence and asthma. METHODS: Alanine or valine polymorphism in the signal peptide of Mn-SOD gene was evaluated using a primer pair to amplify a 107-bp fragment followed by digestion with NgoM IV. RESULTS: No significant difference in genotype frequencies was found between patients and controls. CONCLUSION: These results suggest no major modifying role for the Mn-SOD gene polymorphism in patients with asthma.

Adolescent↗
PubMed2003

Isovaleric acidaemia: cranial CT and MRI findings.

Isovaleric acidaemia is an inborn error of leucine metabolism due to deficiency of isovaleryl-CoA dehydrogenase, which results in accumulation of isovaleric acid in body fluids. There are acute and chronic-intermittent forms of the disease. We present the cranial CT and MRI findings of a 19-month-old girl with the chronic-intermittent form of isovaleric acidaemia. She presented with severe metabolic acidosis, hyperglycaemia, glycosuria, ketonuria and acute encephalopathy. Cranial CT revealed bilateral hypodensity of the globi pallidi. MRI showed signal changes in the globi pallidi and corticospinal tracts of the mesencephalon, which were hypointense on T1-weighted and hyperintense on T2-weighted images.

Amino Acid Metabolism, Inborn Errors↗
PubMedDate not supplied

Effects of inhaled corticosteroids on growth in asthmatic children: a comparison of fluticasone propionate with budesonide.

In asthmatic children inhaled corticosteroids are widely used. However, there are some concerns about the systemic adverse effects of these drugs, especially in the growing child. We performed this prospective study in order to compare the effects of 400 microg/day of budesonide (BUD) and 250 microg/day of fluticasone propionate (FP) on growth in prepubertal (aged 4-11.5 years), moderate persisting asthmatic children. One hundred patients (51 boys and 49 girls), who were randomized into two groups, were recruited for the study. The first group was treated with BUD, 2X 200 microg/day, and the second group was treated with FP, 2X 125 microg/day, by using a medium-size volume-spacer metered-dose inhaler. Growth in children with asthma who were treated by inhaled corticosteroids was calculated by growth velocity over a 12-month period. Comparisons between treatment groups were calculated by t-test and chi-square test. There were no significant differences between BUD and FP groups for sex, age, first height, and growth velocity. Moderate persisting, prepubertal asthmatic children treated with 250 microg/day of FP appeared to have no different linear growth than those children who received 400 microg/day of BUD.

Administration, Inhalation↗
PubMedDate not supplied

Prevalence and risk factors for childhood asthma in Zonguldak, Turkey.

Prevalence of asthma and other allergic diseases varies between different regions throughout the world. The aim of this study was to determine the prevalence of asthma and allergies and some risk factors for asthma in schoolchildren, aged between 6 and 16 years old, in Zonguldak, Turkey. We prepared 1500 questionnaires according to the International Study of Asthma and Allergies in Childhood criteria and distributed them in schools, to be completed at home by parents. Appropriately completed 1349 questionnaires, including complementary questions for risk factors, were taken into consideration. Data for air-pollutant levels of sulfurdioxide (SO2) and total suspended particles were obtained also. The prevalence of current wheezing symptoms was 9.6% in children aged between 13 and 16 years old and 11.2% in the total sample. In terms of physician-diagnosed asthma, allergic rhinitis, and eczema, the prevalences were 4.9, 37.7, and 13.2%, respectively. A family history of allergy, diagnosis, or symptoms of allergic rhinitis and bronchitis (age range, 6-9 years) and male gender were found to be significant predictors for asthma symptoms with adjusted odds ratios of 2.089, 0.336, 4.707, 1.652, and 0.599, respectively. Strongly positive correlation between number of symptomatic asthmatic patients and air pollution levels for SO2 (r = 0.864; p = 0.001) and total suspended particles (r = 0.891; p = 0.001) were observed also. The prevalence of asthma is high in Zonguldak, Turkey, and there is a strong correlation between air pollution and asthma symptoms. Allergy in the first-degree relatives, diagnosis of bronchitis and allergic rhinitis, age, and male gender are more important than the other factors in predicting asthma.

Adolescent↗