In vitro model of cell migration.
Explore the source record for details and available documents.
Animals↗
Biomedical subjects
Neil I Spielholz
Publications and source records attributed to Neil I Spielholz.
Primary writing tremor: report of a case successfully treated with botulinum toxin A injections and discussion of underlying mechanism.
Primary writing tremor (PWT) is a rare motor disorder of unknown etiology, where tremor is elicited primarily or exclusively with writing. We describe a patient with PWT, present a video before and after successful treatment with botulinum toxin type A injections, and discuss a possible underlying dystonic mechanism.
Botulinum Toxins, Type A↗
Electrodiagnostic services in the United States.
Explore the source record for details and available documents.
Age Factors↗
Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.
Explore the source record for details and available documents.
Academies and Institutes↗
Monophasic and biphasic stimulation evoke different responses.
In 31 subjects, psychophysiological sensory perception threshold and the waveform of orthodromic sensory nerve action potentials (SNAPs) produced by constant-current 100-micros monophasic negative pulses were compared to those produced by biphasic (negative-positive) symmetrical pulses (100-micros per phase). In addition, the effects of 200-micros monophasic negative pulses were studied. Graded stimuli were delivered to the index finger, and SNAPs were recorded over the median nerve at the wrist. Perception threshold was significantly different among the three conditions. Furthermore, in 26 subjects, at the lower intensities at which SNAPs first appeared, the evoked potential waveform had two small negative phases with biphasic stimuli, but a single negative phase in response to monophasic pulses. At higher stimulus intensities, all SNAPs had a single large negative phase regardless of the stimulus. These perception and waveform findings suggest that, contrary to historical belief, the trailing positive phase of a biphasic pulse has a stimulating effect at low stimulus intensities.
Action Potentials↗