Biomedical subjects

Nela Bibire

Publications and source records attributed to Nela Bibire.

5 recordsLinked to original sources

PubMedDate not supplied

[Visible spectrophotometric assay of ranitidine].

Ranitidine, belonging to H2-antagonist group, is a compound containing a furanic moiety and is used in peptic ulcer therapy. This paper debates the possibility of developing a new visible spectrophotometric assessment by using the reaction between ranitidine and eosine. We carried out our determinations at 505 nm, where the absorbency of ranitidine-eosine complex is maximal, and we have established the optimal reaction conditions. This method was successfully applied for ranitidine assay from pharmaceutical dosage forms.

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PubMedDate not supplied

[Membrane-selective electrode for atropine assay].

One membrane-selective electrode with PVC matrix for atropine is described, with atropine tetraphenylborate as electroactive material. This electrode has a linear response in the concentration range of 10(-2)-10(-5) M atropine sulphate, with a detection limit of 3.29 x 10(-6) M. This electrode was used with good results for quantitative assay by direct potentiometry and potentiometric titration of atropine sulphate from pharmaceutical formulations.

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PubMedDate not supplied

[Schiff base type onno spectrophotometric determination of magnesium].

By condensing hydrazide salicylic acid with o-hydroxy carbonilic compounds it was obtained 2--hydroxy acetophenon--salicyl hidrazina, Schiff base--type ONNO. These Schiff bis bases present a good capacity of complexing the Mg (II) ions. The above mentioned Schiff base forms complex with Mg (II) cation, with maximum absorbance at 386 nm, and molar absorbtivity (epsilon) = 6.27 x 10(4) mol-1.L.cm-1. The complex with Mg (II) presents a maximum stability at pH = 9.6 - 10.0. The calculated apparent stability constant is K = 3.18 x 10(3). The absorbance is proportional to Mg (II) concentration in the range of 10-60 mg/mL. In this range, the Lambert--Beer law is respected, the linearity coefficient being 0.9818, SD = 0.83, RSD = 0.84 (n = 6). The results obtained for spectrophotometric determination of Mg (II) using this Schiff base as reagent were successfully applied to pharmaceutical products containing Mg (II) cation.

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PubMedDate not supplied

[UV spectrophotometric assay of famotidine in combination with picrolonic acid, picrolinate].

Famotidine, belonging to H2-antagonist group, is a compound containing a thiazolic moiety and it is used in peptic ulcer therapy. This paper debates the possibility of developing a new ultraviolet spectrophotometric assessment by using the reaction between famotidine and picrolonic acid. We carried out our determinations at 362 nm, where the absorbency of famotidine - picrolonic acid complex is maximal, and we have established the optimal reaction conditions. This method was successfully applied for famotidine assay from pharmaceutical dosage forms.

Anti-Ulcer Agents↗

PubMedDate not supplied

[Membrane-selective electrodes for drug analysis. Note II].

Seven membrane-selective electrodes with PVC matrix and liquid-membrane for N-butylscopolamine with different electroactive materials are presented. These electrodes have a linear response in the concentration range of 10(-6) - 10(-2) M N-butylscopolamine bromide, with a detection limit between 4.58 x 10(-7)M and 1.09 x 10(-6)M. These electrodes were used with good results for quantitative assay by direct potentiometry and potentiometric titration of N-butylscopolamine bromide from pharmaceutical formulations. Recovery was between 95.50% and 99.20% for N-butylscopolamine bromide of injectable solutions.

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