Biomedical subjects

Nese Olmez

Publications and source records attributed to Nese Olmez.

4 recordsLinked to original sources

PubMed2006

Serum leptin levels in rheumatoid arthritis and relationship with disease activity.

OBJECTIVES: This study was performed to evaluate serum leptin levels in rheumatoid arthritis (RA) patients and investigate the correlation with serum tumor necrosis factor alpha (TNF-alpha) levels and clinical and laboratory parameters of disease activity. METHODS: Fifty patients with RA and 34 control subjects were included. Disease activity score 28 (DAS28) was calculated for each patient. Laboratory activity was assessed by examining erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). Immunoradiometric assay was used for measuring serum leptin levels (ng/mL). Serum TNF-alpha levels (pg/mL) were measured by sandwich enzyme-linked immunosorbent assay method in 41 of 50 RA patients and in 24 control subjects. RESULTS: Age, sex and body mass index (BMI) did not show a statistically significant difference between RA and control subjects (P > 0.05). Serum leptin levels were higher in RA (P = 0.000). In RA patients, there were no correlations between serum leptin levels and disease duration, swollen and tender joint counts, DAS28, CRP, ESR, serum TNF-alpha levels, oral glucocorticoid and methotrexate usage (P > 0.05). There was no statistically significant serum leptin level difference between patients with high disease activity and mild and low disease activity (P = 0.892). Serum leptin levels positively correlated with BMI in both patient and control groups (P < 0.05). In both groups, mean serum leptin levels were higher in women than men. CONCLUSIONS: Even though serum leptin levels were found to be significantly higher in RA patients than in control subjects in this study, there was no correlation between serum leptin levels and TNF-alpha levels, clinical and laboratory parameters of disease activity. However serum leptin levels positively correlated with BMI in both patient and control groups. In RA, circulating leptin levels do not seem to reflect disease activity.

Arthritis, Rheumatoid↗

PubMed2005

Osteogenesis imperfecta: a case with hand deformities.

In a 51-year-old woman with a history of fractures and dislocations after low intensity trauma in childhood, intensive blue sclera, short stature, and hearing loss, the diagnosis of osteogenesis imperfecta (OI) was suspected. She was referred to our clinic with hand deformities and left knee pain and stiffness. She had difficulty in walking and reported a history of immobilization for 6 months because of knee pain. She had bilateral flexion contracture of the elbows which occurred following dislocations of the elbows in childhood. She had Z deformity of the first phalanges, reducible swan-neck deformity of the third finger of the left and the second finger of the right hand, flexion contracture of the proximal interphalangeal joint of the fifth finger of the left hand, and syndactyly of the third and fourth fingers of the right hand. Flexion contractures of both knees were observed. Pes planus and short toes were the deformities of the feet. Acute phase reactants of the patient were normal. She had no history of arthritis or morning stiffness. Bone mineral density evaluated by dual-energy X-ray absorptiometry (DEXA) showed severe osteoporosis of the femur and lumbar vertebrae. She had radiographic evidence of healed fractures of the left fibula, the third metacarpal, and the fourth and fifth middle phalanges of the right hand. OI, affecting the type I collagen tissue of the sclera, skin, ligaments, and skeleton, presenting with ligament laxity resulting in subluxations and hand deformities may be misdiagnosed as hand deformities of rheumatoid arthritis.

Female↗

PubMed2005

Differential diagnosis of polyuria and polydipsia in a patient with spinal cord injury.

We report the case of a 35-yr-old tetraplegic man who experienced increased water intake, constant thirst, and a copious amount of urine excretion after his spinal cord injury and in whom an intermittent catheterization program was unmanageable. Laboratory evaluation revealed low serum and urine osmolality, which were suggestive of psychogenic polydipsia, and hypokalemia, which might lead to polyuria with a compensatory polydipsia. His water intake was reduced with antidepressant therapy and potassium supplementation and normalized on the third month of the treatment. Physicians should be aware of the differential diagnosis of polyuria and polydipsia, which interfere with neurogenic bladder management in patients with spinal cord injury.

Adult↗

PubMed2004

Intra- and interobserver variability of Kleerekoper's method in vertebral fracture assessment.

Radiographically detected vertebral fractures (VF) are a hallmark of osteoporosis. Several approaches to describe VF have been proposed. The objective of this study was to evaluate the intra- and interobserver variability of semiquantitative Kleerekoper's method in osteoporotic VF assessment. Sixty-seven postmenopausal osteoporotic (L2-4 T-score < or =-2.5) women with a mean age of 65.2+/-7.51 years were included into the study. Lateral radiographs of thoracic and lumbar spine were evaluated in all patients. Kleerekoper's method was used to define VF. Two observers evaluated all radiographs independently. To investigate intraobserver reproducibility, the first observer reevaluated all radiographs a month later on a separate occasion. Intra- and interobserver agreement was calculated using the kappa statistic. The agreement between two readings for the first observer was 86.3% with a corresponding kappa score of 0.573 (95% confidence limits of kappa score were 0.505-0.642). Interobserver agreement was 87.7% with a corresponding kappa score of 0.660 (95% confidence limits were 0.602-0.718). We observed a moderate agreement for Kleerekoper's method in vertebral fracture assessment. There is no gold standard or standardized measurement or description for VF. Quantitative assessment of VF is essential in epidemiologic studies and in clinical drug trials, but a semiquantitative technique, which is done by experienced observers, should also be added to evaluate the entire spectrum of visible features that are helpful in identifying deformities.

Absorptiometry, Photon↗