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Biomedical subjects

Nicholas A Sgaglione

Publications and source records attributed to Nicholas A Sgaglione.

8 recordsLinked to original sources
PubMed2006

Clinical applications of bioactive factors in sports medicine: current concepts and future trends.

The ability to biologically manipulate musculoskeletal healing and augment bone and soft tissue repair and regeneration holds great promise. Advances in the basic science study and clinical application of bioactive proteins and growth factors continues to evolve. Improvement in the surgical resurfacing of articular cartilage defects and tendon and ligament repair through the addition of bioactive polypeptides is currently underway. The purpose of this article is to review the present array of biologically active materials that may be clinically applicable in sports medicine and arthroscopy. Mechanisms for biologic augmentation of tissue repair and regeneration will be discussed. Current limitations and future considerations will be reviewed particularly as they relate to practical clinical approaches.

Arthroscopy↗
PubMed2005

Biologic approaches to articular cartilage surgery: future trends.

The treatment of unicompartmental osteoarthritis and focal chondral pathologic conditions in the knee in active aging athletes has captured the interest of patients, clinicians, basic scientists, and medical industry researchers. Most would agree that a biologic solution to treating hyaline cartilage injuries and degeneration would be optimal over prosthetic joint arthroplasty. Articular cartilage resurfacing techniques and biologic surgical methods continue to evolve and have gained more acceptance in orthopedic practice. A consensus exists for the ultimate goal of achieving a more predictable and durable result after surgical tissue repair or regeneration. Numerous promising approaches are now on the horizon and although the final word is far from in, the integration of many of the anticipated advances in molecular medicine, biomedical engineering, polymer chemistry, cell biology, and clinical orthopedics contributes to an exciting and rapidly evolving field. This article reviews the current concepts of the biologic approach to articular cartilage pathologic conditions and discusses future trends and novel technologies.

Arthroplasty↗
PubMed2004

Allograft bone augmentation in anterior cruciate ligament reconstruction.

Anterior cruciate ligament (ACL) reconstruction is a commonly performed procedure associated with predictable results in most patients. Intraoperative and postoperative complications can occur in up to 20% of surgeries and could result in the need for revision procedures. The following technical report describes the use of allograft corticocancellous bone for supplemental interference fixation of a bone-patellar tendon-bone ACL autograft within a tibial tunnel in which anterior widening occurred as a complication of reaming. This technique was used to obtain and improve aperture outlet fixation of the autograft within the tibial tunnel while maintaining adequate position and tension on the ACL graft-fixation construct. Clinical follow up at 36 months has revealed radiographic incorporation of the allograft into the tibial tunnel as well as optimal subjective, objective, and functional outcomes as measured by patient response, physical examination, and serial KT-1000 (MEDmetric, San Diego, CA) arthrometer data. This technique could be useful in revision cases in which tunnel enlargement and/or widening is noted.

Adult↗
PubMed2002

Update on advanced surgical techniques in the treatment of traumatic focal articular cartilage lesions in the knee.

Considerable interest has been developed over the past several years in expanding the treatment of symptomatic femoral condylar articular cartilage lesions in active patients. Multiple surgical techniques have been reported and evolving technologies, equipment and approaches continue to expand. The purpose of this paper is to review the presentation of focal articular cartilage lesions including treatment indications, current surgical options and postoperative protocols emphasizing advanced techniques used to preserve or restore hyaline cartilage tissue. The various surgical options are discussed and the advantages and disadvantages are reviewed and highlighted in a clinical practice guideline algorithm.

Adolescent↗