Biomedical subjects

Nicholas P Jones

Publications and source records attributed to Nicholas P Jones.

2 recordsLinked to original sources

PubMed2002

Sarcoidosis and uveitis.

Sarcoidosis is a disease initiated by one or more unknown antigens in predisposed hosts, and causes noncaseating granulomatous inflammation. Uveitis is common and may affect any part of the eye. Protean systemic manifestations occur but pulmonary and cutaneous involvement is most common. Diagnosis is important; any suspicious uveitis should be investigated by relevant hematologic, radiologic, and invasive tests. A high proportion of patients require systemic corticosteroid or immunosuppressive treatment for uveitis. A significant minority become visually disabled because of macular scarring, glaucoma, or chorioretinal ischemia.

Diagnostic Techniques, Ophthalmological↗

PubMed2002

Sarcoidosis.

Sarcoidosis commonly involves the eye, causing uveitis, the lacrimal gland, and the cranial nerves, including the optic nerve itself. Several microorganism types have recently been located in sarcoid granulomas, suggesting an infective cause in predisposed individuals. The approach to diagnosis has been refined, including the use of high-resolution computed tomography of the chest. New ophthalmic manifestations have been described, suggesting a wider role for sarcoidosis in intraocular inflammation, and indocyanine green angiography has clarified choroidal involvement. Immunosuppressive and anticytokine treatments can be effective in severe systemic sarcoidosis and should be considered in sight-threatening disease.

Cytokines↗