Biomedical subjects

Nicolas Duval

Publications and source records attributed to Nicolas Duval.

7 recordsLinked to original sources

PubMed2006

Gesture standardization increases the reproducibility of 3D kinematic measurements of the knee joint.

BACKGROUND: The literature on the 3D kinematics of the knee suggests that the gesture accomplished during kinematic assessment might play a significant role in the values measured. The purpose of this study is to demonstrate that a standardized gesture leads to an increased reproducibility in 3D kinematic measurements of the knee. METHODS: Seventeen healthy male subjects performed series of knee-bends in standardized and unconstrained conditions while their left knee's 3D kinematics were recorded using an optical motion-recording system. Standardized knee-bends were performed in a specially designed structure stabilizing the shoulders, pelvis and feet. Coefficient of multiple correlation were calculated for the ascent and the descent phases of the knee-bends for the tibial rotation and abduction/adduction components of the knee movement. FINDINGS: Comparisons between coefficient of multiple correlation of the different gesture conditions showed a statistically significant increase in reproducibility for the tibial rotation during the standardized knee-bends. INTERPRETATION: It appears that gesture standardization is an interesting option to consider for precise kinematic assessment of the living human knee.

Adult↗

PubMed2006

The shunt from the cyclooxygenase to lipoxygenase pathway in human osteoarthritic subchondral osteoblasts is linked with a variable expression of the 5-lipoxygenase-activating protein.

Osteoarthritis (OA) is characterized by articular cartilage degradation and hypertrophic bone changes with osteophyte formation and abnormal bone remodeling. Two groups of OA patients were identified via the production of variable and opposite levels of prostaglandin E2 (PGE2) or leukotriene B4 (LTB4) by subchondral osteoblasts, PGE2 levels discriminating between low and high subgroups. We studied whether the expression of 5-lipoxygenase (5-LO) or 5-LO-activating protein (FLAP) is responsible for the shunt from prostaglandins to leukotrienes. FLAP mRNA levels varied in low and high OA groups compared with normal, whereas mRNA levels of 5-LO were similar in all osteoblasts. Selective inhibition of cyclooxygenase-2 (COX-2) with NS-398-stimulated FLAP expression in the high OA osteoblasts subgroup, whereas it was without effect in the low OA osteoblasts subgroup. The addition of PGE2 to the low OA osteoblasts subgroup decreased FLAP expression but failed to affect it in the high OA osteoblasts subgroup. LTB4 levels in OA osteoblasts were stimulated about twofold by 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) plus transforming growth factor-beta (TGF-beta), a situation corresponding to their effect on FLAP mRNA levels. Treatments with 1,25(OH)2D3 and TGF-beta also modulated PGE2 production. TGF-beta stimulated PGE2 production in both OA osteoblast groups, whereas 1,25(OH)2D3 alone had a limited effect but decreased the effect of TGF-beta in the low OA osteoblasts subgroup. This modulation of PGE2 production was mirrored by the synthesis of COX-2. IL-18 levels were only slightly increased in a subgroup of OA osteoblasts compared with normal; however, no relationship was observed overall between IL-18 and PGE2 levels in normal and OA osteoblasts. These results suggest that the shunt from the production of PGE2 to LTB4 is through regulation of the expression of FLAP, not 5-LO, in OA osteoblasts. The expression of FLAP in OA osteoblasts is also modulated differently by 1,25(OH)2D3 and TGF-beta depending on their endogenous low and high PGE2 levels.

5-Lipoxygenase-Activating Proteins↗

PubMed2005

Comparison of 2 surgical techniques of posterolateral corner reconstruction of the knee.

BACKGROUND: Various surgical techniques to treat posterolateral knee instability have been described. To date, the recommended treatment is an anatomical form of reconstruction, in which the 3 key structures of the posterolateral corner are addressed: the lateral collateral ligament, the popliteofibular ligament, and the popliteus tendon. HYPOTHESIS: Two methods of surgical reconstruction will restore posterolateral knee instability, in terms of static laxity as well as dynamic 6 degrees of freedom kinematics, to statistically significant levels compared with the intact state. STUDY DESIGN: Controlled laboratory study. METHODS: Two surgical techniques (A and B) were used to reconstruct the posterolateral structures in 10 cadaveric knees. Static tests were performed on the intact, sectioned, and reconstructed knees at 30 degrees and 90 degrees of flexion for anterior-posterior laxity and external rotational laxity, as well as at 0 degrees and 30 degrees of flexion for varus laxity; dynamic 6 degrees of freedom kinematic testing, through a path of motion from 90 degrees of flexion to full extension, was also performed. RESULTS: For the static varus tests, external rotation and varus laxity were significantly increased after the posterolateral structures were cut. Both reconstruction techniques restored external rotation and varus laxity to levels not significantly different from the intact state. For technique B, dynamic testing did not show any significant difference for all degrees of freedom kinematics compared with the intact state. However, for technique A, a significant internal tibial rotation was observed throughout the entire path of motion from 0 degrees to 90 degrees of knee flexion. CONCLUSIONS: Both surgical techniques for anatomical posterolateral corner reconstruction showed good results in the static laxity tests. The anatomical reconstruction of all structures, including the popliteus tendon, resulted in an abnormal internal tibial rotation during dynamic testing.

Adult↗

PubMed2005

3D kinematic in-vitro comparison of posterolateral corner reconstruction techniques in a combined injury model.

With the variable injury pattern to the posterolateral structures (PLS) of the knee, a number of reconstructive procedures have been introduced. It was the aim of the present study to evaluate the resulting 3D kinematics following three different surgical techniques of reconstruction in a combined posterior cruciate ligament (PCL)/PLS injury model. In nine human cadaveric knees, 3D kinematics were recorded during the path of flexion-extension using a computer based custom made 6-degree-of-freedom (DOF) testing apparatus. Additional laxity tests were conducted at 30 and 90 degrees of flexion. Testing was performed before and after cutting the PLS and PCL, followed by PCL reconstruction alone. Reconstructing the posterolateral corner, three surgical techniques were compared: (a) the posterolateral corner sling procedure (PLCS), (b) the biceps tenodesis (BT), and (c) a bone patellar-tendon bone (BTB) allograft reconstruction. Posterior as well as rotational laxity were significantly increased after PCL/PLS transection at 30 and 90 degrees of flexion. Isolated PCL reconstruction resulted in a remaining external rotational deficiency for both tested flexion angles. Additional PLS reconstruction closely restored external rotation as well as posterior translation to intact values by all tested procedures. Compared to the intact knee, dynamic testing revealed a significant internal tibial rotation for (b) BT (mean=3.9 degrees, p=0.043) and for (c) BTB allograft (mean=4.3 degrees, p=0.012). (a) The PLCS demonstrated a tendency to internal tibial rotation between 0 and 60 degrees of flexion (mean=2.2 degrees, p=0.079). Varus/valgus rotation as well as anterior/posterior translation did not show significant differences for any of the tested techniques. The present study shows that despite satisfying results in static laxity testing, pathological 3D knee kinematics were not restored to normal, demonstrated by a nonphysiological internal tibial rotation during the path of flexion-extension.

Aged↗

PubMed2005

A reproducible method for studying three-dimensional knee kinematics.

The methods used in movement analysis often rely on the definition of joint coordinate systems permitting three-dimensional (3D) kinematics. The first aim of this research project was to present a functional and postural method (FP method) to define a bone-embedded anatomical frame (BAF) on the femur and tibia, and, subsequently, a knee joint coordinate system. The repeatability of the proposed method was also assessed. Using FP method to define the BAFs, 4 kinematic parameters (flexion/extension, abduction/adduction, tibial internal/external rotation, and antero-posterior translation) were computed for 15 subjects walking on a treadmill. The repeatability for all four kinematic parameters was then assessed, using intra- and inter-observer settings. After pooling the results for all observers, the mean repeatability value ranged between 0.4 degrees and 0.8 degrees for rotation angles and between 0.8 and 2.2 mm for translation.

Adolescent↗

PubMed2002

Vertical acetabular positioning with an inclinometer in total hip arthroplasty.

Vertical acetabular implant positioning is an important technical aspect in total hip arthroplasty. To evaluate the potential benefit of an inclinometer, 50 cup insertions were done on a cadaver pelvis. Acetabular cup vertical angles averaged 44.4 degrees +/- 11.4 degrees by visuospatial perception and 42.2 degrees +/- 3.8 degrees with the inclinometer. All cups were within the safe angle range of 40 degrees to 49 degrees with the inclinometer compared with 64% of cups by visuospatial perception. Use of the inclinometer reduced variability by a factor of 2.0 to 4.5. The addition of an inclinometer for acetabular cup insertion increases the probability of positioning the cup within a vertical safe range during total hip arthroplasty on a cadaver pelvis, suggesting that it could be a useful adjunct in clinical practice.

Arthroplasty, Replacement, Hip↗

PubMed2002

Quantitative comparison of three different types of anterior cruciate ligament reconstruction methods: laxity and 3-D kinematic measurements.

In this project, we compared knee laxity and 3-D knee kinematics after ACL reconstruction on cadaver knees using (1) bone-patellar tendon-bone two-tunnel; (2) synthetic ligament two-tunnel; and (3) synthetic ligament "over-the-top" technique. We used a computer assisted system, based on the acquisition of the knee's movement with magnetic sensors (Polhemus, Vermont, USA). The use of personalised three-dimensional (3D) models of the bones enabled us to ensure a reproducible measurement of three-dimensional kinematic and laxity parameters. Our results showed that even when knee laxity was restored to normal, 3D kinematic measurements revealed that the reconstructions tended to under or over-constrain the knee's movement. This study shows that 3D kinematics is a complementary measurement that can be useful to get a better comprehension of the knee's function after ligament reconstruction.

Aged↗