Biomedical subjects

Nicole Reilly

Publications and source records attributed to Nicole Reilly.

5 recordsLinked to original sources

PubMed2005

Prenatal stress, the hypothalamic-pituitary-adrenal axis, and fetal and infant neurobehaviour.

BACKGROUND: Although it has long been acknowledged that chronic HPA axis dysregulation impacts on adult neural function, little attention has been paid to the impact that disturbances of the maternal HPA axis may have on the developing fetal brain. AIM: This editorial examines the associations between prenatal stress, neuroendocrine functioning, and behavioural outcome in both animal and human offspring, with a particular focus on the relationship between prenatal stress and human fetal and infant neurobehaviour. STUDY DESIGN: Using electronic databases, a computerized search of published and unpublished data was undertaken. RESULTS: There is growing evidence that prenatal stress impacts on offspring neural function and behaviour in animal populations. That these findings may be applicable to human fetal neurobehaviour and infant development and outcome is gaining research attention, and the potential importance of the timing of pregnancy stress is being increasingly highlighted. CONCLUSIONS: There is a pressing need for more research into the role of maternal stress and anxiety during pregnancy on human fetal and infant outcomes. Future studies should prospectively pair physiological and psychological measures both pre- and postnatally if the HPA axis function of the mother and her infant is to be more fully understood.

Behavior↗

PubMed2005

Remote capture of human voice acoustical data by telephone: a methods study.

In this pilot study we sought to determine the reliability and validity of collecting speech and voice acoustical data via telephone transmission for possible future use in large clinical trials. Simultaneous recordings of each participant's speech and voice were made at the point of participation, the local recording (LR), and over a telephone line using a dedicated in-line computerized interactive voice recording system, the remote recording (RR). All voice recordings were made from our laboratory telephone located in Groton, Connecticut to the RR system located in Madison, Wisconsin. All data points were compared on a measure-by-measure basis between the LR and RR recordings. The results suggest that both measures of frequency excursion and of speech motor timing are reliably captured over the telephone. Results are discussed in terms of specific acoustic measures that may be useful and accurately measured via telephone transmission, for examining disease severity and pharmacological intervention for use in a large-scale clinical trial.

Adult↗

PubMed2004

Feigned depression and feigned sleepiness: a voice acoustical analysis.

We sought to profile the voice acoustical correlates of simulated, or feigned depression by neurologically and psychiatrically healthy control subjects. We also sought to identify the voice acoustical correlates of feigned sleepiness for these same subjects. Twenty-two participants were asked to speak freely about a cartoon, to count from 1 to 10, and to sustain an "a" sound for approximately 5s. These exercises were completed three times (within the same testing session) with three differing sets of instructions to the participants. These three conditions were presented in pseudo-random order to control for any order effects, and all subjects were naïve to the intended purpose of this study. For all three conditions, mean speaking rates and pitch ranges were calculated. A series of paired t tests showed significant differences in the speaking rates (counting numbers and free-speech exercises) between the 'normal' and feigned sleepy conditions, and between the normal and feigned depression conditions, but not between the 'sleepy' and 'depressed' conditions. The results for pitch range, for all speech exercises, were not different between the normal and either the feigned depression or feigned sleepiness conditions. These results indicate that persons feigning depression and sleepiness demonstrate some level of conscious control of their speech rate, but they did not convincingly alter their pitch ranges while feigning depression or sleepiness.

Adult↗

PubMed2004

Voice acoustical measurement of the severity of major depression.

A number of empirical studies have documented the relationship between quantifiable and objective acoustical measures of voice and speech, and clinical subjective ratings of severity of Major Depression. To further explore this relationship, speech samples were extracted from videotape recordings of structured interviews made during the administration of the 17-item Hamilton Depression Rating Scale (HDRS; ). Pilot data were obtained from seven subjects (five males, two females) from videotapes that have been used to train expert raters on the administration and scoring of the HDRS. Several speech samples were isolated for each subject and processed to obtain the acoustic measurements. Acoustic measures were selected on the basis that they were correlated with HDRS ratings of symptom severity as seen under ideal voice recording conditions in previous studies. Our findings corroborate earlier reports that speaking rate is well correlated (negatively) with HDRS scores, with a strong correlation and nearly significant trend seen for the measure of pitch variability. A moderate pairwise correlation between percent pause time and HDRS score was also revealed, although this relationship was not statistically significant. The results from this cross-sectional study further demonstrate the ability of voice and speech signal analyses to objectively track severity of depression. In the present case, it is suggested that this relationship is robust enough to be found despite the less than ideal recording conditions and equipment used during the original videotape recording. Voice acoustical analyses may provide a powerful compliment to the standard clinical interview for depression. Use of such measures increases the range of techniques that are available to explore the neurobiological substrates of Major Depression, its treatment, and the dynamic interplay of the systems that govern the motor, cognitive, and emotional aspects of speech production.

Adult↗

PubMed2004

Speech content analysis in feigned depression.

The present study investigated the utility of employing computerized speech content analysis software to detect feigned depression in psychologically healthy adults. Twenty-two subjects between the ages of 19 and 54 years old, who scored lower than 10 on the Beck depression inventory (BDI. 1996), were asked to speak freely in response to a neutral stimulus. Participants performed this task in pseudo-randomized order for two experimental conditions: a control state and feigned depression. Computerized transcript analysis data were then subjected to paired t-tests to detect differences based on participants' lexical choices under the two conditions. Results indicated that one semantic category, tool, was significantly different between the feigned depression and control conditions. Another semantic category of interest, arousal, demonstrated a strong trend toward significance. Computerized lexical choice categories previously found to accurately identify persons with depression were not found to be significantly different in the discourse of our participants in the feigning condition. These results are discussed in terms of the use of computerized speech content analysis as a method for possibly identifying persons who may be intentionally feigning depression.

Adult↗