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Niels Holmark Andersen

Publications and source records attributed to Niels Holmark Andersen.

6 recordsLinked to original sources
PubMed2005

[ALLHAT--epoch-making?].

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Angiotensin-Converting Enzyme Inhibitors↗
PubMed2003

Evaluation of the longitudinal contraction of the left ventricle in normal subjects by Doppler tissue tracking and strain rate.

BACKGROUND: Tissue tracking (TT) and strain rate (SR) are new echocardiographic modalities on the basis of Doppler tissue imaging, which allow assessment of the systolic longitudinal contraction of the myocardium. OBJECTIVE: The aim of this study was to describe the global and regional longitudinal function of the left ventricle by TT and SR analysis. METHODS: The study population consisted of 55 normal subjects. To assess longitudinal myocardial contraction, TT was performed in the standard apical views and expressed as a score index of the 16 myocardial segments. In addition, SR was performed in each segment. RESULTS: The mean longitudinal contraction was 7.8 +/- 1.8 mm. Longitudinal contraction was significantly decreasing with increasing age and systolic blood pressure (r = -0.46, P <.01 for both measures), but independent of heart rate, left ventricular diameters, ejection fraction, and fractional shortening. SR was found significantly larger in the basal segments than in the middle and apical segments (-1.8 +/- 0.6 s(-1) vs 1.4 +/- 0.3 s(-1) P <.001). CONCLUSION: TT and SR analysis are easily obtained and may complement conventional measures of left ventricular systolic function.

Echocardiography, Doppler↗
PubMed2002

Angiotensin converting enzyme inhibitors and angiotensin II receptor blockers: evidence for and against the combination in the treatment of hypertension and proteinuria.

Several treatment guidelines have made strong recommendations to physicians that treatment of nephropathy and hypertension should be based on the use of a long-acting angiotensin converting enzyme (ACE) inhibitor if tolerated. The recently published clinical trials, based on angiotensin II receptor blockers' effects on diabetic nephropathy and essential hypertension, have also shown significant endpoint reduction. Perhaps the time has come to broaden the recommendations to include the use of a renin-angiotensin-aldosterone system altering drug. But what if the treatment goal cannot be reached, and incessant proteinuria and high blood pressure levels persist despite high dosage treatment of either drug? How should this be handled? The dual blockade principle can possibly provide the solution by obtaining the broadest and most efficient blockade of circulating angiotensin II by using the combination of an ACE inhibitor and an angiotensin II receptor blocker. But large clinical trials are yet to come, and at present large endpoint trials have not been published. This article provides an overview of how far we have come with dual blockade treatment in hypertension and nephropathy.

Angiotensin Receptor Antagonists↗