Bilateral charnley low-friction arthroplasty with cement in a patient with pyknodysostosis. A case report.
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Abnormalities, Multiple↗
Biomedical subjects
Nikhil Shah
Publications and source records attributed to Nikhil Shah.
Evolution of cemented stems.
John Charnley was responsible for pioneering successful cemented hip arthroplasty. Changes in stem design were made in response to early complications such as stem fracture. Various philosophies of stem biomechanics emerged, namely stems performing in the taper slip mode and stems performing as a composite beam. Both stem designs may be successful, although it is important not to mix biomechanical philosophies. Later evolutions have occurred in response to surgical flexibility, specifically modularity and offset options. These attributes can impart new demands on the stem and, in some cases, retrograde developments have occurred. Cemented stems may yield excellent long-term results and have the potential to limit fixation to the proximal femur and establish a metaphyseal-loading regimen. The latest design of taper slip stems, such as the C-stem (DePuy Orthopaedics, Warsaw, Ind), may have advantages in maintaining proximal bone stock and preserving host bone. The historical developments and evolution of the cemented stem in total hip arthroplasty (THA) are discussed.
Biomechanical Phenomena↗
Software for automating analysis of encoded combinatorial libraries.
This paper describes the applications which are used to automate the analysis of encoded combinatorial libraries. Commercial packages from MDL, Oracle and Agilent are linked with application software written in C/C++, in Microsoft Access and in ChemStation macro language. Encoding correspondence lists for each of up to three synthetic steps are conveniently associated with building block lists using the first application, CodeGen. The second application Decode allows the user to identify the individual beads picked onto a 96-well plate and the pool number for each bead. The decoding chromatography data for each well is then loaded into the program. The chromatography data is used to identify the tags used in the synthesis. Along with the building block information from ISIS/Host, the building block used in each step of the synthesis can be identified. A third routine, Code-to-Structure, takes the coded library building blocks and creates the connection table in ISIS for each structure found by the decode program. For quality control of encoded library synthesis, the decoded structures on a set of beads is compared to the LC/UV/MS data for the ligand cleaved from the same bead. CAPTURE, a GlaxoSmithKline proprietary application, is used to display and analyze the decoded structures and associated mass spectral data. This application uses simple isotopic composition and electrospray ionization rule sets to predict mass spectra and judge the concordance of a structure- mass spectrum data set. An ancillary program, EIC, is used to extract predicted single ion chromatograms from the full scan LC/MS data.
Combinatorial Chemistry Techniques↗