Biomedical subjects

Nimrod Maril

Publications and source records attributed to Nimrod Maril.

5 recordsLinked to original sources

PubMed2006

Sodium MRI of the human kidney at 3 Tesla.

The sodium concentration gradient in the kidney (from the cortex to the medulla) serves to regulate fluid homeostasis and is tightly coupled to renal function. It was previously shown that renal function and pathophysiology can be characterized in rat kidneys by measuring the sodium gradient with (23)Na MRI. This study demonstrates for the first time the ability of (23)Na MRI to map the distribution of sodium in the human kidney and to quantify the corticomedullary sodium gradient. The study was performed on a 3T Signa LX scanner (GE) using an in-house-built quadrature surface coil. (23)Na images of volunteers were acquired using a 3D coronal gradient-echo sequence at a spatial resolution of 0.3 x 0.3 x 1.5 cm(3) in a 25-min scan time. The signal intensity (relative to the noise) increased linearly from the cortex to each of the medullae with a mean slope of 1.6 +/- 0.2 in relative arbitrary units per mm (Rel.u./mm, N = 6) and then decreased, as expected, toward the renal pelvis. Water deprivation (12 hr) induced a significant increase of 25% (P < 0.05) in this gradient. Based on these results, we suggest that sodium MRI can serve as a valuable noninvasive method for functional imaging of the human kidney.

Adult↗

PubMed2005

An automated algorithm for combining multivoxel MRS data acquired with phased-array coils.

PURPOSE: To develop a fully automated algorithm for combining multivoxel magnetic resonance spectroscopy (MRS) data acquired with a phased-array coil. MATERIALS AND METHODS: The frequency-domain fitting method of LCModel (Provencher SW, Magn Reson Med 1993;30:672-679) was utilized to analyze the individual data sets. The phase corrections and the metabolite areas were then extracted from the LCModel output files for each individual spectrum. These areas were used to determine the dominant metabolite for each spatial location and to combine the individual spectra in a weighted manner. RESULTS: The combination of MRS data acquired from a phantom and the brains of normal volunteers with a four array coil yielded improved signal-to-noise ratio (SNR) in all voxels. The average improvement in SNR of the combined spectrum, as compared with the best of the individual spectra at each spatial location, was 1.4. In the phantom, the predicted SNR improvement of two-fold was achieved at the center of the sample. In the brain, the maximum improvement was 1.8, due to sampling of the ventricles in the center of the sample. CONCLUSION: The method described in this report provides a means for employing phased-array coils in MRS with the same advantages as those found in MRI.

Algorithms↗

PubMed2005

Sodium magnetic resonance imaging of diuresis: spatial and kinetic response.

Renal function is highly correlated with the sodium concentration gradient along the corticomedullary axis. The application of 3D high-resolution sodium magnetic resonance imaging (MRI) provided a means to quantify in vivo the spatial and temporal changes in renal tissue sodium concentration under normal and diuretic conditions. A detailed, pixel-by-pixel analysis of the intact rat kidney sodium MR images yielded a quantitative measure of the corticomedullary sodium gradient before and at early and later times after the administration of two distinct diuretic agents, furosemide and mannitol. Furosemide, a loop diuretic, induced a fivefold reduction in the cortical-outer medullary sodium gradient, whereas mannitol, an osmotic diuretic, did not affect this gradient. Both diuretics induced a 50% decrease in the sodium concentration of the inner medulla; however, mannitol exerted its effect twice as fast as furosemide with a 2.5-min exponential decay constant. These specific changes were attributed to the different mechanism of action and site of activity of each diuretic agent. Thus, high-resolution (23)Na MRI offers a unique, noninvasive tool for functional imaging of the kidney physiology.

Analysis of Variance↗

PubMed2005

Strategies for shimming the breast.

There is evidence in the literature indicating a significant static field inhomogeneity in the human breast. A nonhomogenous field results in line broadening and frequency shifts in MRS and can cause intensity loss and spatial errors in MRI. Thus, there is a clear rationale for determining the regional variations in the static field homogeneity in the breast and providing strategies to correct them. Herein, the nature and extent of the static magnetic field at 3 T were measured in central planes of the human breast using both phase maps and multivoxel MRS techniques. In addition, the effect of first- and high-order shimming and of spatial saturation pulses on the static field inhomogeneity was evaluated. Both the theoretical and the measured field were found to be primarily linear in nature, with a reduction of 300 Hz from the nipple to the chest wall. First-order shimming reduced this inhomogeneity by 65%. Interestingly, the combination of spatial saturation pulses and first-order shimming was more effective than high-order shim alone. Since many clinical scanners do not have either higher-order shim or automated higher shimming algorithms that work in the presence of fat, the suggested combination provides an effective means to correct inhomogeneities in the breast.

Adult↗

PubMed2004

Functional sodium magnetic resonance imaging of the intact rat kidney.

BACKGROUND: Renal fluid homeostasis depends to a large extent on the sodium concentration gradient along the corticomedullary axis. The spatial distribution and extent of this gradient were previously determined by invasive methods, which yielded a range of results. We demonstrate here the capacity of sodium magnetic resonance imaging (MRI) to quantify non-invasively renal sodium distribution in the intact kidney. METHODS: Sodium MRI was applied to study normal, diuretic, and obstructed rat kidneys in vivo. The images were recorded at 4.7 Tesla using a 3-dimensional gradient echo sequence, with high spatial and temporal resolution. The tissue sodium concentration (TSC) was obtained by taking into account the measured nuclear relaxation rates and MRI visibility relative to a reference saline solution. RESULTS: The corticomedullary sodium gradient increased linearly from the cortex to the inner medulla by approximately 31 mmol/L/mm, from a TSC of approximately 60 mmol/L to approximately 360 mmol/L. Furosemide induced a 50% reduction in the inner-medulla sodium and a 25% increase in the cortical sodium. The kinetics of these changes was related to the specific site and mechanism of the loop diuretic. Distinct profiles of the sodium gradient were observed in acute obstructed kidneys, as well as spontaneously obstructed kidneys. The changes in the sodium gradient correlated with the extent of damage and the residual function of the kidneys. CONCLUSION: Quantitative assessment of the renal corticomedullary sodium gradient by high resolution sodium MRI may help verify new aspects of the kidney concentrating mechanism and serve as a non-invasive diagnostic method of renal function.

Acute Disease↗