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Biomedical subjects

Nora Goldschlager

Publications and source records attributed to Nora Goldschlager.

10 recordsLinked to original sources
PubMed2006

Implantable cardiac arrhythmia devices--part I: pacemakers.

Implantable cardiac devices have become firmly entrenched as important therapeutic tools for a variety of cardiac conditions. The first part of this two-part review will discuss the contemporary use and follow-up of pacemakers, while the second part will address the use of implantable cardioverter defibrillators and implantable loop recorders. Pacemakers are the only available treatment for symptomatic bradycardia not due to reversible causes. Large randomized studies have demonstrated a small but statistically significant reduction in atrial fibrillation associated with pacing modes that maintain atrioventricular synchrony. In contrast, pacing mode appears to have a less dramatic effect in patients with atrioventricular block. Cardiac resynchronization with specialized left ventricular leads has been shown to reduce symptoms and improve survival in patients with symptomatic heart failure, systolic dysfunction, and widened QRS complexes. For all patients, careful follow-up is necessary to ensure optimal therapeutic benefit of pacing systems.

Arrhythmias, Cardiac↗
PubMed2006

Implantable cardiac arrhythmia devices--Part II: implantable cardioverter defibrillators and implantable loop recorders.

Implantable cardiac devices have become firmly entrenched as important therapeutic tools for a variety of cardiac conditions. The second part of this two-part review discusses the contemporary use and follow-up of implantable cardioverter defibrillators (ICD) and the implantable loop recorder. The ICD has become the standard therapy for protecting patients against sudden cardiac death. Two recent trials, the Multicenter Automatic Defibrillator Trial II (MADIT II) and the Sudden Cardiac Death Heart Failure Trial (SCD-HEFT), demonstrated that the ICD is associated with a significant survival benefit for patients with reduced ejection fraction (< 0.30-0.35), particularly if heart failure symptoms are present. The ICD has an important role in the management of other conditions associated with a high risk for sudden death, such as hypertrophic cardiomyopathy, long QT syndrome, and Brugada syndrome. The implantable loop recorder has become an important diagnostic tool for the patient with unexplained syncope.

Arrhythmias, Cardiac↗
PubMed2006

Status of computerized electrocardiography.

Since the first reports on computerized ECG analysis were published in the early 1960s, there have been major advancements in this technology that have led to the availability of a computer interpretation for nearly all ECGs processed in the United States. Misinterpretation of the ECG is still a problem, however, especially with rhythm diagnoses and correctly identifying pacemaker activity. A sound understanding of the strengths and limitations of the current computer analysis programs is essential to avoid over-reliance on computer analysis and to prevent the inappropriate management of patients. The reliability of computerized ECG analysis programs will only continue to improve, and the degree to which expert readers will continue to be needed remains to be seen. In the meantime, until there is true automated ECG analysis, computerized interpretations should be viewed as an adjunct to, not a substitute for, interpretation by a competent and experienced physician.

Electrocardiography↗
PubMed2005

Beyond heart rhythms: new directions for implantable devices.

Implantable cardiac devices have become firmly entrenched as important therapeutic tools for a variety of conditions. Pacemakers are the only available treatment for symptomatic bradycardia not due to reversible causes. Large randomized studies have demonstrated a small but statistically significant reduction in atrial fibrillation associated with pacing modes that maintain atrioventricular synchrony. In contrast, pacing mode appears to have a less dramatic effect in patients with atrioventricular block. Cardiac resynchronization with specialized left ventricular leads has been shown to reduce symptoms and improve survival in patients with symptomatic heart failure, systolic dysfunction, and widened QRS complexes. The implantable cardioverter defibrillator has become the standard therapy for protecting patients against sudden cardiac death. Two recent trials, Multicenter Automatic Defibrillator Trial II (MADIT II) and the Sudden Cardiac Death Heart Failure Trial (SCD-HEFT), demonstrated that the ICD is associated with a significant survival benefit for patients with reduced ejection fraction (< 0.30-0.35) particularly if heart failure symptoms are present. Finally the implantable loop recorder has become an important diagnostic tool for the patient with unexplained syncope. This brief overview summarizes the indications and follow-up of the wide array of implantable cardiac devices available to the clinical cardiologist.

Arrhythmias, Cardiac↗
PubMed2003

Pseudo-cross-stimulation due to first degree AV block.

During routine interrogation of a dual chamber pacemaker, atrial pacing stimulus outputs were found to coincide with surface electrogram QRS complexes raising concern for cross-stimulation. Scrutiny of the native rhythm, however, confirmed this to be "pseudo-cross-stimulation" where marked first degree AV block resulted in alignment of atrial stimulus outputs with preceding QRS complexes. Although cross-stimulation is rare, familiarity with cross-stimulation and pseudo-cross-stimulation is important because its recognition will avoid erroneous diagnoses of lead dislodgment or device malfunction.

Atrioventricular Node↗
PubMedDate not supplied

Pacing therapy in the elderly.

Bradycardia due to sinus node dysfunction and atrioventricular block is more commonly observed in the elderly. Aging is associated with progressive fibrosis in both the sinus node and atrioventricular conduction system (AV node, His bundle, right and left bundles). In the absence of reversible causes implantation of a permanent pacemaker is often required in the patient with symptomatic bradycardia. For elderly patients with sinus node dysfunction, pacing modes that preserve atrioventricular synchrony are associated with a reduced incidence of atrial fibrillation and improved quality of life. For patients with atrioventricular block, the importance of preserving atrioventricular synchrony in the elderly is controversial and is currently being evaluated.

Aged↗