Norberto Fredotovich | PubMed Health

PubMed2005

[Percutaneous renal surgery with minimal access: miniperc].

OBJECTIVES: To describe the technique of the minimal access percutaneous nephrolithectomy, miniperc, and to analyze the results obtained with this treatment in adult patients. METHODS: We performed 42 minipercs between august 2002 and December 2003. Mean patient age was 48 years (19-62). The procedure was undertaken using a 14Fr Amplatz sheath. Stone size varied from 1.5-3.5 cm in longest diameter (1.5-7 cm2). Lithofragmentation was performed by pneumatic lithotripsy. RESULTS: Average procedure time was 75.2 min. (range from 60 to 120). All patients were discharged within 24 hours. Only three patients (7.1%) have a hematocrit descent over 2 points. No nephrostomy tube was left for the postoperative time. 95.2% of the patients were stone free 1 month after surgery. CONCLUSIONS: Our results make us consider the minimal access percutaneous nephrolithectomy (Miniperc) a minimal option for the elimination of renal stones, with low morbidity, diminishment of the hospital stays, very low analgesic demand, and no transfusion requirements.

Adult↗

PubMed2004

A double-blind randomized placebo control study comparing the objective and subjective changes in female sexual response using sublingual apomorphine.

INTRODUCTION: Female sexual dysfunction and its therapeutic approach is a growing area. AIM: We aimed to assess the subjective and objective changes of the female sexual response, in patients with orgasmic sexual dysfunction using 3 mg SL Apomorphine (APO). METHODS: Twenty-four patients (mean age 32 years old, SD: 9.69) were included in a prospective randomized cross-over protocol. Sexual response was evaluated objectively (duplex ultrasound) and subjectively (self-reported questionnaire) following vibrator stimuli with the addition of 3 mg SL APO or placebo. MAIN OUTCOME MEASURE: Sexual response objective (PSV, EDV, RI) and subjective (arousal and lubrication degree and orgasm achievement). Adverse events were also recorded. RESULTS: Clitoral hemodynamical changes, particularly peak systolic velocity (PSV), were significantly higher with APO (P = 0.003), mean increase of PSV poststimulus was 72.50% with placebo (from 9.7 cm/second to 17.0 cm/second) and 139.14% with APO (from 9.7 cm/second to 21.4 cm/second). SUBJECTIVE CHANGES (AROUSAL AND LUBRICATION) WERE ALSO SIGNIFICATIVE WITH APO (P < 0.05). CONCLUSION: According to our observations, APO seemed to produce more subjective and objective changes in the sexual arousal phase of women with orgasmic sexual dysfunction than placebo. Future research is needed to evaluate the place of this drug in the treatment of the female sexual dysfunction.

Administration, Sublingual↗