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Biomedical subjects

O A Beck

Publications and source records attributed to O A Beck.

At least 19 recordsLinked to original sources
PubMed1979

[Influence of digitalis on pindolol activity in exercise-induced cardiac failure in patients with coronary disease (author's transl)].

The activity of the beta-receptor blocker pindolol (0.4 mg i.v.) was investigated alone and in combination with digitalis (moderately fast loading) in 12 patients with coronary heart disease and without manifest signs of cardiac insufficiency. These patients showed pathological increase of left ventricular filling pressure during exercise testing. The exercise-induced rise of the mean pulmonary arterial and capillary pressures were increased by pindolol. Concurrently the increase of cardiac frequency was clearly diminished during ergometry (from 107/min without pindolol to 96/min, P less than 0.005). Digoxin given orally for an average of 5 days prevented the pressure increase in the pulmonary circulation induced by pindolol during exercise testing and at rest. The frequency reducing effect of pindolol was potentiated by digitalis. Use of digitalis alone did not influence mean exercise-induced pressure increase of the pulmonary circulation. In fact in some cases deterioration of these parameters was observed.

Acetyldigoxins↗
PubMed1978

[Indications and risks of anti-arrhythmia treatment with propafenone (author's transl)].

Propafenone, a new anti-arrhythmia drug, was given at an average dose of 70-140 mg (1-2 mg/kg body-weight) to 124 patients with various types of cardiac arrhythmias. It proved successful in patients with ectopic beats and tachycardias of atrial or ventricular origin. Ectopic beats were suppressed in 40 of 81 patients, while sinus rhythm was restored in 15 of 19 patients with paroxysmal tachycardias. On the other hand, sinus rhythm was restored in only 5 of 22 patients with atrial tachy-arrhythmias, while in most of the others in this group the heart rate decreased markedly during propafenone injection. The effect of propafenone was on atrial and ventricular myocardium and on the conduction system, lowering the discharge rate of sinus node and ectopic pacemakers. ECG signs of pre-excitation disappeared in 4 of 9 patients with WPW syndrome given the drug. Propafenone may prolong atrioventricular and intraventricular conduction, as well as cause a transitory decrease in cardiac function and a fall in systemic arterial blood pressure. It should, therefore, not be given to patients in severe heart failure, hypotension or shock, or with high-degree atrioventricular, intraventricular or sinoatrial block.

Adult↗
PubMed1978

[Propafenon and lidoflazine in chronic atrial fibrillation and flutter (author's transl)].

60 patients with chronic atrial fibrillation and flutter were randomly allotted to two groups and treated alternately with two different therapy regimes. 30 patients (group I) received lidoflazine in increasing dosage up to 480 mg/24 h and in cases where there was no conversion to sinus rhythm propafenon in a maximal daily dosage of 1800 mg orally. The duration of treatment was limited to 4 days for each substance. 30 patients (group II) were treated in the reverse order, i.e. propafenon and in cases of ineffectiveness with lidoflazine. Atrial fibrillation could be overcome in 21 patients in group I and in 23 patients in group II. The combined success rate in both groups was 73%. The conversion rates for the individual substances were 41% for propafenon (17 out of 41 patients) and 59% for lidoflazine (27 out of 46 patients). The difference was not statistically significant. Successive use of both substances leads to an increased conversion rate. Dangers arising from therapy are a conduction inhibitory action and depression of sinus node function as far as propafenol is concerned and the risk of ventricular ectopy and tachyarrhythmia in lidoflazine.

Aged↗
PubMed1978

[Comparison of the effects of digitalis and nitroglycerine in coronary heart disease with cardiac failure on exercise (author's transl)].

The effects of moderately rapid oral digitalization and sublingual nitroglycerine were studied in 13 patients with coronary heart disease without signs of manifest heart failure but definite rise in pulmonary artery pressure on ergometric exercise. Digitalis had no effect on exercise-induced rise in pulmonary pressure. In the individual case there may be a clear-cut deterioration in exercise response. This possible unfavourable digitalis effect cannot be predicted in a given case from the clinical state and thus one must critically assess digitalis treatment in coronary heart disease without manifest heart failure. On the other hand, the favourable effect of nitroglycerine in lowering pulmonary arterial pressure at rest and preventing an abnormal pressure rise on exercise underlines its value in the treatment of both compensated and uncompensated coronary heart disease.

Aged↗
PubMed1978

[The effect of nifedipine on the pulmonary artery pressure in patients with coronary heart disease (author's transl)].

Nifedipine was administered in a dose of 30 mg orally to 14 patients with coronary heart disease and clinical evidence of left heart failure. Measurements of pulmonary artery and pulmonary wedge pressure were performed before and 1, 2 and 4 hours after administration of Nifedipine at rest and under loading conditions. The effects were characterized by a significant decrease in systolic, mean and enddiastolic pulmonary artery pressures by 18--21%. The pulmonary wedge pressure decreased significantly from 2,3 to 1,6kPa (17 to 12 mm Hg). These changes were accompanied by a significant decrease in systolic and diastolic arterial pressure by an average of 10.5%. No signifcant change of heart rate was seen. The increase in pulmonary artery pressure during exercise is suppressed effectively by Nifedipine. The duration of activity lasted for four hours and was maximal in the second hour after administration of the drug. The suppression of exercise induced rise of pulmonary wedge pressure was paralleled by a substantial decrease in dyspnoea and anginal pain.

Aged↗
PubMed1978

Correlation between serum concentration and pharmacological effect on atrioventricular conduction time of the antiarrhythmic drug propafenone.

Seven patients with cardiac dysrhythmias received a single, oral, therapeutically effective dose of the antiarrhythmic drug propafenone. The serum levels correlated well with changes in atrioventricular conduction times during the postabsorptive elimination phase (r = 0.8610, p less than 0.001). The mean half-lives of the serum level and the electrocardiographic effect (PQ-time) were 3.6 +/- .2 h and 3.8 +/- 0.6 h, respectively.

Adult↗
PubMed1978

[Comparative effects of ajmaline and lidocaine on hemodynamics in myocardial infarct].

Haemodynamic changes after single intravenous injection of antiarhythmic doses of ajmaline (50 mg) and lidocain (100 mg) were measured comparatively in 10 patients with acute myocardial infarction, stable cardiac rhythm and without manifest left heart failure. The effects of ajmaline were characterized by a significant decrease of systolic arterial pressure (9%), of left ventricular stroke work index (15%) as well as by an increase of the mean pressure of the pulmonary artery (7%) in the early phase after application. No significant changes in cardiac index, stroke volume index, systemic vascular resistance, right and left ventricular filling pressures and heart rate occurred. The effects of lidocain on the cardiac circulation were comparatively small. The intravenous administration of lidocain did not result in significant changes of the cardiac index or left and right ventricular filling pressures. Diastolic arterial pressure increased significantly (5%), while the heart rate decreased (5%).

Ajmaline↗
PubMed1978

[Peculiarities of diagnosis and treatment in hypertension of the aged (author's transl)].

It can be noted, a consequently discovered and treated hypertension is one of the most important achievements of modern medicine within the last 20 years. The earlier treatment begins, the better it success of treatment in avoiding complications on the basis of arterio sclerosis and expectation of life. For elderly hypertensives it is particularly important, what is good in younger decades too - but in higher age the acute threat of life by hypertension is much more pronounced.

Adrenergic beta-Antagonists↗
PubMed1978

[The comparative hemodynamic effects of antiarrhythmic drugs in acute myocardial infarction (comparison of propafenone and lidocaine) (author's transl)].

Hemodynamic changes after single intravenous injection of antiarrhythmic doses of propafenone (70 mg) and lidocaine (100 mg) were measured comparatively in 11 patients with acute myocardial infarction, stable cardiac rhythm and without evidence of manifest left heart failure. The effects of propafenone were characterized by a significant decrease of cardiac index by 6% and an increase in left and right ventricular filling pressures by 15% and 23%. Mean arterial pressure was significantly lowered (8%) and left ventricular stroke work index decreased by an average of 11%. Mean pulmonary artery pressure significantly increased by 7%. A fall in systemic vascular resistance by 7% was not statistically significant. Intravenous administration of propafenone at a dose of 70 mg thus caused a transitory decrease in ventricular function and acute vasodilation with a fall in systemic blood pressure. The intravenous administration of lidocaine did not result in significant changes of cardiac index or left and right ventricular filling pressures. Mean pulmonary artery pressure, systemic blood pressure and vascular resistance increased significantly.

Aged↗
PubMed1978

[Antiarrhythmic effect of propafenone in relation to serum concentration and conduction time (author's transl)].

7 patients with stable cardiac dysrhythmias (ectopic beats of ventricular origin) received a single oral dose of 900 mg Propafenone. Besides the antiarrhythmic effect of propafenone the effect on changes of PQ- and QRS duration as well as the corresponding serum concentration was measured. A significant correlation between changes of PQ-time and serum concentration (r = 0.6810, p less than 0.001) was found. The half-life of serum level was 3.6 +/- 0.2 h, that of PQ-time prolongation 3.8 +/- 0.6 h. A complete suppression of all ectopic beats has been achieved in all treated patients for 6--8 hours.

Adult↗
PubMed1978

[Course and prognosis of patients with myocardial infarction during 7 years (observations in a cardiological clinic with an intensive care unit (author's transl)].

In a group of 701 male patients with acute myocardial infarction treated in intensive care unit from 1969 to 1976 30.0% died within the time of 1969--71 during the stay in the clinic. The lethality decreased significantly to 22.3% from the year 1972 until 1973, between 1974 and 1976 to 21.7% respectively, while the average age of the patients was growing. The number of patients with myocardial infarction in the age group of 50 to 69 years has decreased since 1974, whereas the number of patients in the age group of 70 years and older has increased, lethality sinking in this age group (from 57.4% 1969--71 to 32.3% 1974--1976). The incidence of threatening disorders of cardiac rhythm and their lethality has decreased. The high lethality of patients with cardiogenic shock remained unchanged high.

Adult↗
PubMed1978

[Action of the calciumantagonistic compound gallopamile on sinus node, atrioventricular and intraventricular conduction (author's transl)].

The influence of the calciumantagonistic agent Gallopamile (D 600) on cardiac conduction and sinus node function was studied by using His bundle recordings and atrial stimulation in 13 patients with normal sinus rhythm. Intravenous administration of a single dose of 4 mg produced a significant increase in the atrioventricular conduction time by 30 %. On atrial stimulation second degree a-v block occurred at lower stimulation rates in all patients after Gallopamile. The impulse propagation in atrial tissue and within the His-Purkinje system was not affected, even in patients with diseased conduction system. There was an impairment in sinus node automaticity, the sinus node recovery time was increased by 58 % of the control value.

Adult↗
PubMed1978

[Transmural and nontransmural myocardial infarction. Clinical course and prognosis (author's transl)].

In a group of 701 patients with acute myocardial infarction treated in the intensive care unit from 1969 to 1976 557 ((79,5%) had a transmural infarction. The clinical course in these patients was significantly more aggravated by haemodynamic complications especially left and right heart failure and cardiogenic shock. The pericarditis appeared with an incidence of 10,4% as complication of transmural myocardial infarction only. Atrioventricular block, supraventricular ectopies, ventricular fibrillation and intraventricular disturbance of conduction occurred more frequently in patients with transmural myocardial infarction. Corresponding to the larger size of infarction the maximal average rise of serum enzymes (SGOT, CPK) was observed in this group. The hospital mortality was 28,2%, compared to 11,2% of the patients with nontransmural infarction.

Berlin↗
PubMed1977

[Pericarditis after acute myocardial infarction (author's transl)].

909 patients were treated between 1970 and 1975 in an intensive-care unit for acute myocardial infarction. 91 (10%) had associated pericarditis. In these patients the clinical course was characterised by a significantly high incidence of haemodynamically severe complications such as left and right heart failure and cardiogenic shock, as well as rhythm and conduction disturbances. High grade atrioventricular block, intraventricular conduction disturbances, ectopic and tachycardic supraventricular arrhythmias and ventricular ectopic rhythms occurred much more frequently in patients with infarct-pericarditis than in those without it. The occurrence of pericarditis indicates an extensive infarction and thus a worse prognosis. The hospital mortality of pericarditis was significantly higher (61%) than in the remaining 818 patients without it (24.4%). Anticoagulation did not increase the risk of haemopericardium.

Acute Disease↗