Biomedical subjects

O A Bud'ko

Publications and source records attributed to O A Bud'ko.

2 recordsLinked to original sources

PubMed2006

[Necrotizing fasciitis: pathophysiological and clinical aspects of the problem].

The data of literature and results of treatment of 17 patients with necrotizing fasciitis are analyzed. Original conception of pathogenesis based on thrombosis of microcirculatory vessels of superficial fascia is described. Endotoxemia manifested with clinical picture of sepsis and septic shock. Successful treatment is possible in cases of early diagnosis, urgent surgical treatment and intensive antibiotic therapy. Urgent cryobiopsy of tissues is an important diagnostic point. Lethality was 50% (it reaches 75% according to the literature data), this can be explained by late hospitalization and delayed operation.

Adult↗

PubMed2005

[Necrotizing fasciitis].

An experience with treatment of four patients with necrotizing fasciitis (NF) and a review of literature were used to characterize this rare but dangerous for life disease, The pathogen of NF is a hemolytic group A streptococcus and anaerobes. The mechanism of the development of fasciitis is based on impairments in the microcirculatory bed due to the action on the cytokine endothelium. Rapidly progressing necrosis of fasciae results in a number of complications. The treatment consists of the early and aggressive necrectomy and intensive antibiotic therapy in combination with immunomodulation.

Adult↗