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Biomedical subjects

O A Kozdoba

Publications and source records attributed to O A Kozdoba.

At least 19 recordsLinked to original sources
PubMed1989

[Hypertensive disease and renal hypertension (structural and functional studies of the kidneys using dynamic computerized tomography)].

Renal functional and structural studies were performed in 46 patients with arterial hypertension: out of them 12 had hypertensive disease, 13, chronic pyelonephritis, 21, a hypertensive type of chronic glomerulonephritis. In each case, the clinical diagnosis was evidenced by one of the invasive techniques. Dynamic computed tomography was conducted by the original methods; the findings were analyzed by taking into account time-density curves which made it possible to gain an insight into the status of blood flow and filtration in each individual kidney. Computed tomography and dynamic computed tomography revealed that hypertensive disease was characterized-by normal volume and thickness of the renal cortical layer and symmetric time-density curves, whereas a hypertensive type of chronic glomerulonephritis featured lower renal cortical layer thickness, reduced renal volume, symmetrically decrease amplitudes of the first and second peaks of the time-density curve, chronic pyelonephritis showed asymmetric time-density diagrams due to the lower density areas in the afflicted kidney.

Adult↗
PubMed1987

[Comparative effectiveness of the combined outpatient-hospital and outpatient treatments of hypertension patients with high and stable arterial pressure indices].

The paper is concerned with an analysis of the effectiveness of the outpatient and hospital stages in the treatment of patients with essential hypertension with stable and high AP indices. The absence of significant changes in the time course of AP, the number and nature of complications and the number of days of temporary disability was shown in 197 patients treated in the groups of outpatient and outpatient-hospital therapy.

Absenteeism↗
PubMed1986

[Lesions of target organs in arterial hypertension].

A total of 530 patients with a variety of hypertensive conditions, including 476 patients with labile and stable essential hypertension, 40 with hypertensive chronic diffuse glomerulonephritis and hypertensive chronic pyelonephritis, and 14 with vasorenal hypertension, were investigated. Structure and function of target organs (the heart and the kidneys) were assessed by means of echocardiography (530) and intravital morphologic studies of renal biopsy specimens (89). A heterogeneous nature of hypertrophic developments associated with essential hypertension was demonstrated, with adequate, inadequate, disproportionate and excessive hypertrophy identified, while no correlation could be found between the kind of hypertension and the degree and nature of hypertrophy. Renal morphologic changes were also shown to be heterogeneous in labile and stable arterial hypertension, and early involvement of the renal mechanism presenting as structural changes was found to be possible.

Adult↗
PubMed1986

[Long-term observation (8-10 years) of patients with mild forms of arterial hypertension].

The nature of a course of "mild" arterial hypertension was studied in 126 patients for 8-10 yrs. It was shown that in 13.2% of the cases arterial pressure returned to normal values during a "natural" course of disease; border-line arterial hypertension was revealed in 9.4%. Stage II hypertension was diagnosed in 77.4% of the cases after 7-10 yrs. Progression of arterial hypertension was noted in this group in 1/3 of the cases (30.2%). Aggravated heredity and an initial morphological state of the kidneys (according to the results of intravital morphological investigation) were shown to be predictors of prognosis of arterial hypertension. The initial picture of the fundus of the eye and electrocardiographic signs of myocardial hypertrophy reflected the nature of a course of hypertension being not factors determining prognosis of arterial hypertension stabilization.

Adolescent↗
PubMed1985

[Characteristics of left ventricular hypertrophy in patients with different forms of arterial hypertension based on echocardiographic data].

Echocardiographic investigation of 110 patients with different forms of stable arterial hypertension demonstrated a moderately close correlation between left-ventricular myocardial weight, and systolic and diastolic arterial blood pressure in patients with essential hypertension and chronic diffuse glomerulonephritis, and a weak correlation between left-ventricular myocardial weight and systolic pressure in patients with renovascular hypertension and chronic unilateral or predominantly unilateral pyelonephritis. Inadequate left-ventricular hypertrophy has similar incidence (15-20%) in patients with different forms of arterial hypertension, whereas excessive hypertrophy only occurs in patients with essential hypertension. The frequency of asymmetrical hypertrophy differs in the two groups.

Adult↗
PubMed1982

[Combined renal forms of symptomatic arterial hypertension].

In high arterial hypertension conditioned by main renal arteries stenosis of different genesis, 21.1% of patients were found to have a combination of renovascular hypertension with parenchymatous renal diseases, most often chronic pyelonephritis. The incidence of development of the malignant hypertension syndrome in combined lesions was noted to be 1.5 times higher than in isolated renovascular hypertension and makes 38.8% of patients. The described features of the clinical course, laboratory, radiological and radionuclide data as well as morphologic state of kidneys make it possible to distinguish this form of symptomatic hypertension as a special one, that is renovascular-parenchymatous hypertension.

Chronic Disease↗
PubMed1982

[Diagnosis of latent forms of symptomatic arterial hypertension in young patients].

A study of 174 patients has established that renal biopsy is of principal value for differential diagnosis in 70 per cent of cases where the origin of high and stable arterial hypertension of young patients is difficult to establish, and the results of a preliminary investigation fail to suggest a reliable diagnosis. In 73 per cent of the patients with the given clinical symptoms, arterial hypertension was symptomatic and associated with latent renal disease. Morphological investigation of biopsy specimens established the nature of the process resulting in the development of arterial hypertension as well as its pattern and activity in the absence of pathognomonic clinical and laboratory signs.

Adolescent↗
PubMed1979

[Fluorescein angiographic studies of the fundus oculi in the malignant arterial hypertension syndrome].

Fluorescein-angiographic examination of fundus oculi in 33 patients with the syndrome of malignant hypertension made it possible to recognize for the first time changes in the choriocapillary layer, which in 29 patients were displayed by choroidal retention; ischemic zones were seen in 20 patients. It is suggested that the discovery of ischemic zones in the choriocapillary layer may be an early diagnostic criterion of malignant hypertension.

Adult↗
PubMed1977

[Value of puncture biopsy of the kidneys on the side of the stenosis in renovascular hypertension. I].

The morphological picture of bioptic renal tissue was studied in 23 patients with different forms of vasorenal hypertension, among whom 12 had fibromuscular dysplasia of the renal arteries, 8 had atherosclerotic stenosis, and 3 had panarteritis of the aorta and its branches with involvement of the renal arteries. The syndrome of malignant hypertension was encountered in 13 patients and stable arterial hypertension with high blood pressure levels in 10 patients. Analysis of the bioptic material allowed it to be divided into two groups: the 1st was marked by a picture of "Selye's kidney" and the 2nd by a combination of stenosis of the renal arteries and parenchymatous diseases of the kidneys. The significance of examining the morphological picture of renal bioptates, both with regard to the study of the pathogenesis of vasorenal hypertension and the diagnosis of concomitant parenchymatous process is shown.

Adult↗