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Biomedical subjects

O A Ladipo

Publications and source records attributed to O A Ladipo.

14 recordsLinked to original sources
PubMed1978

Menstrual regulation in Ibadan, Nigeria.

Menstrual regulation (MR) (i.e., vacuum aspiration of the uterus with a small diameter, flexible cannula before pregnancy can be determined by a conventional pregnancy test) has been proven safe and effective in many clinics around the world. The present study, which we believe is the first such study of MR in Subsaharan Africa, shows that, for women in an urban African setting, MR is an acceptable backup for other contraceptive methods. Data on 507 MR patients treated at the University College Hospital in Ibadan, Nigeria, between January 1974 and April 1976, showed that the procedure was both safe and effective for 93.4% of the study subjects: there was an overall complication rate of 3.4% and MR failed in seven cases (3.2%). Data also showed that MR is an effective method of recruiting new contraceptive acceptors, as well as an effective back-up procedure in case of contraceptive failure.

Adult↗
PubMed1978

Ureaplasma urealyticum (T. mycoplasma) and male infertility in topical countries.

In view of the potential role of ureaplasma urealyticum in reproductive failure, sample of semen from 100 Nigerian males was cultured in oxoid mycoplasma broth. In 39% of the patients, Uraeplasma uraelyticum was cultured. Of those with positive culture, 92.3% were infertile patients. Five subfertile males achieved pregnancy in their partners after eradication of the ureaplasma urealyticum by a course of tetracycline.

Humans↗
PubMed1978

Correlation of birthweight with foeto-maternal immunoglobulin, total protein and albumin profile.

Using immunodiffusion and biuret methods, immunoglobulins (GAMD), total proteins and albumin measurements were performed at birth on 100 apparently healthy Nigerian mothers and their babies. Sizeable concentrations of IgG were present at birth even in babies with low birth weights (1360 mg/100 ml). The mean IgG level in babies with low birth weights (2,500 g or less) was significantly lower (P less than 0.05) than in average weight and above average weight babies. The mean maternal and cord IgG levels were approximately equal in all except in the low birth weight babies where the mean maternal level was about 40% higher than the mean cord level. The scatter in IgG values was more pronounced in babies with low birth weights than the others. Mothers with higher IgG levels than in their corresponding babies were most prominent in the 'low birth weight' group. There was no significant difference between the maternal as well as between the cord serum IgA and IgM levels. The mean cord serum IgA and IgM levels were about 4 and 10% respectively of their mothers. Compared with the Caucasians, relatively higher quantities of IgD were found in the Nigerian mothers. Twenty-one percent of the maternal and all the cord sera had no detectable amount of IgD. The mean maternal total proteins though higher than the cord serum proteins, showed no statistical difference. The foeto-maternal serum albumin differential, showed statistical difference when average weight babies and above average weight babies were considered (P less than 0.05) but not with low birth weight babies (P less than 0.2).

Adolescent↗
PubMed1977

Prevention of Rh-hemolytic disease.

The results of Anti (D) immunoglobulin (RhoGAM) therapy in 25 Rh-negative women after delivery of Rh-positive babies are presented. None of the patients studied showed evidence of Rh-isoimmunization while two of 51 unprotected patients subsequently had antibodies detected in their serum. The incidence of Rh-negative patients is low in this environment. Because of the potential risk of isoimmunization, RhoGAM prophylaxis is advocated.

Adult↗
PubMed1976

Preterm and other babies with low birthweights in Ibadan.

Earlier studies on the incidence of low birthweight babies were unanimous in the belief that this is a peculiarity of the developing countries, especially of the negro race. However, the more recent studies have shown that the differences in the incidence of low birthweights between the developed and developing countries might be due to other factors. In a study of birthweights in Ibadan, Nigeria, evidence was presented which showed that the level of socio-economic standards, rather than the peculiarity of geographical location or race, accounted for a high percentage of low birthweight babies. The various other factors associated with low birthweight babies in Ibadan were also highlighted.

Female↗
PubMedDate not supplied

Serum immunoglobulin levels in normal, premature and postmature newborns and their mothers.

Immunoglobulin (Ig) levels (IgG, IgA, IgM and IgD) were measured in 92 paired maternal and cord sera by the modified single radial immunodiffusion method. There was a progressive increase in mean IgG levels as the gestational age increased which reached a maximum of 1771 mg/100 ml in the postmature babies. The mean IgG level of infants of 32--36 weeks' gestation was lowest (1395 mg/100 ml). The maternal IgG levels were generally higher than those of the cord sera. The mean maternal IgG level (1773 mg/100 ml) was considerably higher than the corresponding level in the cord sera of the lowest gestational age group. Such marked difference was not present in newborns who were of normal gestational ages. The mean IgA and IgM levels of the cord sera were low. There were no significant differences between the mean IgA and IgM levels of newborns in different gestational age groups, even when their mothers showed variations in mean IgA and IgM levels. There was no detectable level of IgD in the cord sera.

Adolescent↗
PubMedDate not supplied

Pseudocyesis in infertile patients.

In the African population, pseudocyesis is not an uncommon gynecologic disorder. The high premium on childbearing, as well as the deep-rooted cultural belief that children are a "security of old age" and continuation of the family, exposes the infertile woman to constant stress. The social and psychological satisfaction of parenthood is very important in this culture; while, for some patients, perception of the economic implication of children enhances the desire to have children.

Adult↗
PubMedDate not supplied

Experience with PGF2 alpha in mid-trimester pregnancy termination in Ibadan.

Twenty-five cases of mid-trimester pregnancy termination using intra-amniotic PGF2 alpha are described. The dose of PGF2 alpha used ranged between 40 and 80 mgs. Eighty-eight percent of all patients received 66mg or less of PGF2 alpha. Complete abortion without surgical intervention occurred in 13 (52%) of the women. The mean instillation abortion interval was 22 h. Surgical intervention was required in twelve patients. Side effects, mainly gastrointestinal symptoms, occurred in 72% of our patients. No epileptic seizure or cervical laceration was reported. It is suggested that the use of prostaglandin for pregnancy termination should be restricted to large medical centres with adequate facilities for coping with complications. Introduction of mid-trimester abortion with prostaglandin offers a back up method for failed contraception and obviates the need for surgical dilation of the cervix with its attendant risks.

Abortion, Induced↗