Biomedical subjects

O A Osinupebi

Publications and source records attributed to O A Osinupebi.

3 recordsLinked to original sources

PubMed2005

Aetiology of catheter-associated bacteriuria in Lagos University Teaching Hospital.

A prospective study to determine the causative agents of catheter-related bacteriuria was carried out on 99 patients with median age of 55 years, on admission in the Oncology, Paediatric Surgery and Obstetric and Gynaecology wards of the Lagos University Teaching Hospital. There was significant bacteriuria in seventy-one (72%) of the 99 urine samples. All catheter urine samples were contaminated by day 5 Gram-negative bacilli were predominant (89.3%) of which Pseudomonas aeruginosa (26.2%) was the most common, while Escherichia coli and Enterobacter aerogenes accounted for 15.5% each, closely followed by Proteus mirabilis (14.3%) and Klebsiella pneumoniae (9.5%). The Gram positive isolates Enterococcus faecalis (8.3%) and Staphylococcus saprophyticus (2.4%) made up only 10.7% of isolates. Most of the isolates from catheterised patients were resistant to the common antibiotics such as ampicillin, cotrimoxazole, gentamicin and ceftriaxone with high susceptibility to ofloxacin and ceftazidime though the isolates of Enterococcus faecalis was also resistant to ofloxacin. However, isolates of S. saprophyticus were still susceptible to the penicillins and tetracycline.

Adolescent↗

PubMed2003

Significant asymptomatic bacteriuria among Nigerian type 2 diabetics.

Significant asymptomatic bacteriuria is a risk factor for symptomatic urinary infection and septicemia among predisposed individuals such as diabetics. We investigated the pattern of asymptomatic bacteriuria among our type 2 diabetics with a view to documenting the prevalence, type of organisms responsible and the antibiotic susceptibility pattern. One hundred and twenty-four type 2 Nigerian diabetics (55 males and 69 females) submitted midstream urine specimens for culture. Thirty-three patients had significant bacteriuria (9 males and 24 females), showing the frequency of occurrence of asymptomatic bacteriuria to be 26.6%. The most common organism isolated was Klebsiella pneumonia at 42.4%. Gram-negative bacilli made up about 23 (69.7%) of the isolates. Isolates were poorly sensitive to the readily available antibiotics (ampicillin, tetracycline and cotrimoxazole), but a large number of the organisms isolated were sensitive to nitrofurantoin, gentamicin, ciprofloxacin and ofloxacin. Sensitivity to erythromycin, nalidixic acid and cefuroxime was moderate. Asymptomatic bacteriuria is, thus, more prevalent among the Nigerian diabetic population than in the non-diabetics. A changing pattern of disease is observed with Klebsiella sp. now accounting for the majority of asymptomatic bacteriuria among diabetics. The organisms are not sensitive to the commonly available antibacterial agents.

Anti-Bacterial Agents↗

PubMed2003

Bacteraemia--a Sagamu perception.

In this study laboratory records of all positive blood cultures at Olabisi Onabanjo University Teaching Hospital between January 1993 and December 1998 were reviewed and analyzed. A total of 2057 samples of blood cultures were received in the laboratory during the period of study. 495 (24.1%) samples yielded significant growth of microorganisms. 87 (17.6%) of the positive cultures were from the out patients. Most of the positive blood cultures (99.6%) were mono-microbial. A total of 497 isolates were obtained. The predominant organisms isolated were Klebsiella species (30.8%), Staphylococcus aureus (30.8%), atypical coliforms (11.9%) and Pseudomonas species (7.5%). There were more gram-negative organisms 309 (62.2%) than gram-positive organisms 188 (37.8%). Staphylococcus aureus (30.8%) and Staphylococcus epidermidis (5.0%) were the predominant gram-positive organisms isolated. A large number (>50%) of the organisms isolated were resistant to Ampicillin and Gentamicin but were sensitive to third generation cephalosporins and quinolones. In conclusion, this study demonstrates the need for all hospitals to monitor the microorganisms causing septicemia so that the clinicians can be alerted to a suitable strategy for blind therapy.

Adult↗