Biomedical subjects
Publications and source records attributed to O A Zamiatin.
The methodology and end results of interstitial radiotherapy and combined and complex limb-preserving treatment for carcinoma of the mucosa of the tongue and fundus of the oral cavity have been studied. 60Co ionizing radiation pin-sources with high-level activity at tips were employed.
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The report deals with new procedures of interstitial, complex and combined treatment of cancer of the tongue and mucosa of fundus of the oral cavity with time space-differentiated doses of radiation. If indicated, cervical lymph nodes undergo surgery at the final stage of therapy. Interstitial radiotherapy has proved a highly-effective radical component of said treatment for cancers of the tongue and oral cavity.
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Statistical data on the morbidity of malignant tumors to be treated by interstitial radiotherapy were used to calculate the requirements in radiosurgery over the country, including the requisite number of radiological and "active" bed for the management of patients with malignant tumors of the tongue and oral mucosa. Several variants of the organization of radiosurgery service in cancer institutions were analyzed.
The authors summed up foreign and Soviet literature data as well as their own clinical experience in the means of introducing radiation sources as one of the most important element of technical equipment of interstitial radiotherapy. They consist of means for the preparation of introducing sources, an instrument and appliances for introducing intrastats, an instrument and apparatus for introducing the sources. Pin-type sources with 60Co are taken as an example of meeting the requirements of means of introduction.
The authors proposed a new model of dosimetric design of combined gamma-therapy of patients with oral mucosa tumors on the basis of F. Ellis' modified model with account of a therapeutic volume of tissues to be irradiated, and Henschke's model describing a focal dose optimum value in interstitial gamma-therapy as a function of its volume. The proposed model is based on the concept of relative (partial) tolerance which is equal to a ratio of values of a dose delivered to a therapeutic volume to a tolerance dose and differs from the formula of partial tolerance described by Orton and Ellis.
The authors compared the results of the designing of interstitial irradiation using the Paris system and the optimum scheme of placing radiation sources. The qualities of formed dose fields were compared by 5 criteria characterizing a dose field at the border, in the center and beyond the target as well as its homogeneity by volume. The correlation showed the advantages of planning using optimal schemes in volumes with an elliptical and irregular section by the criteria of homogeneity of target contour irradiation, the lessening of radiation exposure beyond the target and an increase in the absolute value of minimum dose rate at the border of an irradiated volume.
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The authors present an analysis of the causes of radiation induced complications in 383 patients referred to the Chair of Clinical Radiology from different medical institutions of the country. It was found that under distant gamma therapy, to prevent the development of complications the value of TDF-factor should not exceed 105--110, for the associated radiotherapy--130--140, and that for close focal roentgenotherapy--130--150. In vast majority of patients (95.3%) the complications resulted from surpassing the normal tissue tolerance. To prevent radiation injuries it is suggested to take into consideration the TDF-factor values, while in planning radiotherapy to choose such schedules of irradiation, which preclude any surpassing of the tolerance of normal tissues and organs adjacent to the tumor.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.