Age of onset in cluster headache: the clinical spectrum (three case reports).
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Age of Onset↗
Biomedical subjects
O Albrecht
Publications and source records attributed to O Albrecht.
Effect of a reduced vitamin K supplementation on prothrombin time in prematures and high-risk neonates.
Recommendations for vitamin K supplementation were recently changed to 3 x 1 mg orally in healthy term neonates and 0.2 mg parenterally in prematures and high-risk neonates. Prothrombin times (PT) at reduced vitamin K doses (120 patients, 170 samples) during the first 6 weeks of life were below 40% in 6 patients only; all low PTs were unrelated to vitamin K. In the remaining patients, median PT was 100%; 79% of patients had values above 70%. PT was related to birthweight, gestational age and age. There was no decrease over the observation period. Following reduced oral and parenteral vitamin K regimens PTs were well within published reference values for neonates given larger amounts of vitamin K.
Administration, Oral↗
Macromolecular adducts caused by environmental chemicals.
We describe three biomonitoring studies in which hemoglobin (Hb) adducts were used as biochemical markers to assess indirectly the target dose of genotoxic chemicals. We monitored the exposure to 1,3-butadiene in occupationally exposed workers and in two control groups by analyzing the adducts formed by the reaction of the first activation product, butadiene monoepoxide, with the terminal valine of Hb; we also measured hydrolyzable adducts formed by the reaction of metabolically formed nitroso derivatives with Hb from five selected nitropolycyclic aromatic hydrocarbons (1-nitropyrene; 2-nitrofluorene, 3-nitrofluoranthrene, 6-nitrochrysene, and 9-nitrophenanthrene) in coke oven workers of different job categories and control workers of the same geographical area. We detected hydrolyzable adducts from monocyclic nitroarenes in blood from individuals living in a contaminated area where explosives had been produced and from controls. The contaminants considered were 2,4,6-trinitrotoluene; 2,4- and 2,6-dinitrotoluene; and 1,3-dinitrobenzene. Differences between groups were significant, but interindividual variation was great and back-ground exposures must be considered.
Biomarkers↗
Mixtures of lecithin with polymerizable derivatives of cholesterol. A monolayer film balance study.
One of the best investigated binary lipid mixtures is the lecithin-cholesterol system. We show here that it is possible to modify the cholesterol in such a way that it can be polymerized without changing its behaviour in mixtures with lecithin. The polymerizable derivatives exhibit a very similar phase diagram in the mixture with dipalmitoylphosphatidylcholine as the cholesterol itself. This is demonstrated by filmbalance measurements.
1,2-Dipalmitoylphosphatidylcholine↗
Stable biomembrane surfaces formed by phospholipid polymers.
Phospholipids (phosphatidylcholines) with diacetylene in each acyl chain have been deposited in Langmuir-Blodgett multilayers on a variety of substrates. Upon irradiation the diacetylene groups polymerise and link the phospholipid molecules together with a conjugated chain made up of alternating single, double and triple bonds. Advantage has been taken of this polymerisation process to increase the stability of these lipids layers and to produce stable biomembrane hydrophilic surface. These surfaces may be useful for studies of blood coagulation and protein adsorption. In addition they could also have medical application.
Biopolymers↗
[Results of incidence analyses in external hemorrhoids].
The perianal region of 294 healthy persons (151 male, 143 female) of different age was examined and the size, the localization and the number of the skin tags were registered. The frequency increases in women especially at the beginning of the second decade and in men especially at the fourth decade of life. 80% of all women and 60% of all men have skin tags. The size of the skin tag increases while the person becomes older. In the average women have bigger skin tags than men. Most of the skin tags are located in the region of 12 and 6 h lithotomy position.
Adolescent↗