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Biomedical subjects

O Aochi

Publications and source records attributed to O Aochi.

At least 19 recordsLinked to original sources
PubMed1990

Effects of prostaglandin I2 and a selective thromboxane synthetase inhibitor on the arteriolar constriction caused by norepinephrine.

Effects of prostaglandin (PG) I2 and thromboxane (Tx) A2 on the systemic blood pressure, the internal diameter of arterioles with a diameter of 20 to 30 microns, and the change caused by the topical administration of norepinephrine (NE) were studied in the rat mesentery. The change in diameter was measured by an image-shearing eyepiece and television microscopy. The rats were divided into three groups. Group I (9 rats) served as the non-treated, control group. In group II (6 rats), PGI2 was given at the rate of 0.6 micrograms/kg/min for ten minutes. In group III (6 rats), (E)-3-[4-(1-imidazolylmethyl)phenyl]-2-propenoic acid hydrochloride monohydrate (OKY 046), which is a highly selective TxA2 synthetase inhibitor, was administered at the rate of 0.5 mg/kg/min for ten minutes. The hypotension caused by PGI2 administration was accompanied by arteriolar constriction, although it disappeared with the increase in the systemic blood pressure five minutes after administration of PGI2 was stopped. The systemic blood pressure and the internal diameter of arterioles showed no change in the OKY 046 and in the control group. The vasoconstrictive response to NE was inhibited by PGI2 and OKY 046 for thirty to forty-five minutes and the inhibitory effects were similar in both cases. These results show that PGI2 and a selective Tx synthetase inhibitor, OKY 046, attenuate the vascular response to NE.

Acrylates↗
PubMed1985

Diabetic osteopenia in central Japan.

A large scale study of diabetic osteopenia was conducted in central Japan. The degree of bone mass loss was measured in 1267 diabetic patients and 646 control subjects. Based on six indices obtained by microdensitometry, the bone mass of 21.1% of the diabetic patients was found to be markedly decreased and that of 8.2% was found to be severely decreased, while only 7.9% of the control group showed bone mass loss. The prevalence of diabetic osteopenia in female patients was significantly higher than in males, but a positive correlation between the degree of bone mass loss and age was observed in both the male and female patients. Patients requiring oral agents or insulin had significantly more bone mass loss than those on dietary therapy alone.

Adolescent↗
PubMed1977

Optimum humidification of air administered to a tracheostomy in dogs. Scanning electron microscopy and surfactant studies.

The effect of the inhalation of dried (less than 40% water-saturation) or humidified air (100% water-saturation at 25, 30, 35 and 40 degrees C) was studied in dogs in which a tracheostomy had been performed to determine the optimal humidity. After inhalation for various periods, the dogs were killed and pieces of lung tissue were excised for analysis of surfactant. Sections of the trachea and the primary to tertiary bronchi were taken for scanning electron microscopic examination. Structural changes were observed in the trachea of dogs inhaling dried at and in the tertiary bronchi of dogs inhaling 100% water-saturated air at 35 degrees C. No changes was observed after 24 h in dogs which had inhaled 100% water-saturated air at 25 degrees C under anaesthesia or at 30 degrees C without anaesthesia. Consequently, the optimal range of humidity was determined to be 100% water-saturation between 25 and 30 degrees C.

Air↗