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Biomedical subjects

O Appenzeller

Publications and source records attributed to O Appenzeller.

At least 73 records · Page 4Linked to original sources
PubMed1976

[Transcutaneous nervous stimulation in the treatment of hemicrania and other forms of headache].

Transcutaneous administration of a slightly painful electrical stimulus was employed in the management of migraine and other forms of headache in 35 patients with various pictures of pain. Stimulation during crisis led to its total disappearance in 6 subjects with migraine. A relatively high percentage of successes was noted in the remaining patients, with persistence up to 8 months. The theory of "gate control" is cited to explain this effect. Stress is laid on the particular suitability of the method in the management of chronic headache, since it is not associated with either dependence or toxic medicamentous effects.

Acute Disease↗
PubMed1976

[Headache in the pathology of small cerebral blood vessels: study of patients with systemic lupus erythematosus].

Seventy-two records of patients with systemic lupus erythematosus were reviewed retrospectively. Sixty-one fulfilled the criteria for the disease. Forty-six percent had clinical evidence of central nervous system involvement. The incidence of headache was compared in those with and without central nervous system lupus. No difference in the frequency of headache in the two groups was found and the incidence of hypertension, renal disease and steroid therapy was equally distributed among those with and without headache. A significantly higher incidence of hypertension was found in patients with central nervous system lupus erythematosus. We conclude that headache in systemic lupus erythematosus in the absence of neurologic symptoms or signs is no indication of central nervous system involvement by the process and that small vessel disease of the brain is not a cause of headache.

Adolescent↗
PubMed1976

Acromutilating, paralyzing neuropathy with corneal ulceration in Navajo children.

Four Navajo children had a mutilating neuropathy with severe motor involvement. The disorder appears to be recessively inherited and is present from the earliest observable age. Manifestations include severe anesthesia, corneal ulceration, painless fractures, acral mutilation, and weakness. Mental function is normal. Sural nerves are practically devoid of myelinated fibers that show no evidence of regeneration. Unmyelinated axons show degenerative and regenerative morphologic and histometric features. Onion bulb formation is absent. We believe this neuropathy is a distinct clinical entity.

Axons↗
PubMed1975

[Transcutaneous nerve stimulation for the treatment of migraine and other head pain (author's transl)].

35 patients suffering from different painful conditions were treated with transcutaneous application of a slightly painful electrical stimulus. The effect was manifested in complete relief in six patients treated during an attack of migraine and in a relatively high number of other cases of headache with relief of pain. In some cases there was a long-lasting favourable effect for periods up to 8 months. For the theoretical explanation the 'gate control' theory is referred to. With respect to the practical application, the special indication in cases of chronic headache is emphasised, especially since this method avoids the risks of habit-formation or other damaging effects of drug therapy.

Electric Stimulation Therapy↗
PubMed1975

The oculo-cerebral-renal syndrome of Lowe.

Clinical, light microscopical, ultrastructural, and biochemical studies were done on nerve and muscle biopsy specimens from five patients with the oculo-cerebral-renal syndrome of Lowe. Four patients were American Indians, a racial group in whom this disease has not previously been recognized. The hypotonia, areflexia, and diffuse atrophy of muscles are associated with slowed motor nerve conduction velocities, and the morphologic changes in sensory nerves are attributed to a "dying-back" phenomenon probably resulting from an unknown metabolic derangement.

Abnormalities, Multiple↗
PubMed1975

Sea-blue histiocytes and sural nerve in neurovisceral storage disorder with vertical ophthalmoplegia.

Ultrastructural investigation of bone marrow histiocytes in neurovisceral storage disorder associated with vertical ophthalmoplegia revealed 3 types of cytosomes: (1) lamellar cytosomes; (2) larger cytosomes composed of lamellar fragments and a granular component; and (3) large irregular cytosomes with amorphous and granular portions, often including fingerprint profiles--in some of these, lysosome-like bodies were numerous. The lamellar cytosomes corresponded to vacuoles seen by light microscopy. The Type 2 and 3 cytosomes were the ultrastructural substract of Wright-Giemsa stained blue granules. Histiocytes having a predominance of Type 2 cytosomes in a cytoplasm rich in free ribosomes had the appearance of sea-blue histiocytes at the light-microscopic level. Transformed Type 1 cytostomes served as building blocks for Type 2 and 3 cytosomes. In the sural nerve, Schwann cells and endoneurial fibroblasts accumulated autofluorescent lipopigment but no lamellar cytosomes or their fragments were found on electron-microscopic examination. Ultrastructure of sea-blue histiocytes in this disease differed from that observed in some other diseases.

Adult↗