[Oral cytostatic agents in the prevention of urothelial carcinoma. Our experience].
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Biomedical subjects
Publications and source records attributed to O Arango Toro.
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OBJECTIVE: To analyze the preoperative diagnostic methodology in a series of patients with complicated cystic renal masses in relation to the definitive anatomopathological findings. METHOD: 20 cases of asymptomatic complicated cystic renal masses in 19 patients submitted to surgical exploration are described. All cases were evaluated by US and CT. Fine needle punction-aspiration biopsy (FNPA) was done in 17 of the 20 masses and pre and postoperative anatomopathological analyses were performed. RESULTS: Following the Bosniak classification for complicated cystic masses, the US study showed two cases were type I, 5 type II, 10 type III, and 3 type IV, while the CT findings showed no type I, 8 type II, 9 type III and 3 type IV. The definitive anatomopathologic diagnosis was that of renal cell carcinoma in 11 cases. All but one (type II) of these 11 cases were Bosniak III or IV. Nine had a preoperative FNPA which showed malignant cells in two cases, while the remaining 7 were negative. The preoperative biopsy was negative in one of the 11 cases with renal cell carcinoma. The remaining 9 cases of complicated renal mass were simple cysts complicated by hemorrhage or infection. CONCLUSIONS: In our series, the use of the Bosniak classification system preoperatively highly correlated with the presumed benign or malignant nature of the lesion. FNPA biopsy, however, was not found to be very useful in the preoperative diagnosis of complicated cystic renal masses; it showed a sensitivity of 22% and a negative predictive value of 46.7%. Although the foregoing data have no statistical significance, a negative FNPA biopsy of a complicated cystic renal mass that raises reasonable doubts does not change the indication for a surgical exploration.
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Three cases of prostatic abscess diagnosed in our service in the past year are reported. The current treatment of this disease entity and the changes observed relative to the pathogenic flora of prostatic abscess in certain groups at risk today are discussed. All three cases underwent percutaneous transperineal debridement of the purulent collection. An 8 Fr silicone catheter was left indwelling in the residual cavity of the abscess to permit lavage with povidone-iodine solution during the first 3 or 4 days post-operatively. At one week, the abscess had completely resolved in all of the cases as evidenced by the ultrasound control. E. coli was isolated in two patients with diabetes and Staph. aureus was isolated in an HIV-positive intravenous drug addict who also had renal abscess from Candida albicans.
A case of poorly-differentiated leiomyosarcoma of the bladder is described. Diagnosis was established by immunohistochemical and ultrastructural analyses. The therapeutic possibilities in this aggressive tumor type are described.
We report a case of paratesticular angiosarcoma. To our knowledge, no well-documented case involving this site has been reported in the literature. The anatomopathological features of the present case are described, highlighting immunohistochemical analysis. The outstanding clinical features of this aggressive tumor type are discussed.
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Small cell carcinoma of the bladder ("oat cell") is a very uncommon tumor. Its sudden onset, rapid progression to an often fatal outcome and early metastatic spread are the main clinical features of this tumor. Immunohistochemical staining for neuroendocrine markers is positive in a large number of cases. A case of small cell carcinoma of the bladder is described. The clinical course of the patient, as well as the histopathological and immunohistochemical findings are presented.
The results of semen examination in 313 vasectomized males are presented. A quantitative analysis of the semen samples was performed according to the WHO criteria and the centrifugate of the entire ejaculate was studied. At the first semen examination, which was performed three months after the procedure, the sperm count per ml was negative in 210 patients (83.7%), positive (all non-motile and dead) in 41 (16.3%). Sixty-two patients did not send a sample. Those cases with a positive first examination had a regular examination every two months. At five months 90.8% of these cases had a negative count per ml. 3.6% of the patients required 7-10 months to have a negative count. It took longer for the older patients to have a negative count, the difference being statistically significant with respect to the younger patients. Examination of the centrifugate revealed spermatozoa in 24.3% of the samples with a negative sperm count per ml, although these were all non-motile and dead, except for one case who had motile spermatozoa at 3 months. There were no pregnancies or revasectomies. Some legal aspects relative to patient examination and follow-up are discussed.
Over the last few years a number of testicular tumours in seropositive patients or patients with AIDS-diagnostic factors have been described in the literature with no clear relationship having been established between both conditions. Most authors believe management should not differ from that being given to non-immunodeficient patients. The paper presents one case of non-seminomatous germinal tumour in a 41-year old homosexual patient, HIV positive, with unfavourable evolution in spite of the treatment received.