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Biomedical subjects

O B Smith

Publications and source records attributed to O B Smith.

6 recordsLinked to original sources

Micronutrients and reproduction in farm animals.

Reproductive well-being and performance of farm animals is largely dependent on their nutritional status, which is often less than optimum in developing tropical countries. More often than not, they are malnourished, particularly with regards to micronutrients. Evidence was presented to show that because these micronutrients are involved in such functions as intracellular detoxification of free radicals, synthesis of reproductive steroids and other hormones, carbohydrate and protein and nucleic acid metabolism, their deficiencies and/or excesses may impair spermatogenesis and libido in the male, fertility, embryonic development and survival, post-partum recovery activities, milk production and offspring development and survival. A plea was made for intensified research efforts, farmer education and quality control of vitamin-mineral pre-mixes, in order to improve micronutrient nutrition, and, consequently, the reproductive performance and overall productivity of farm animals in developing tropical countries.

Animals↗

Recovery of phenytoin from solutions of caseinate salts and calcium chloride.

The recovery of phenytoin from solutions of intact protein components of enteral nutrition products was studied. Diluted phenytoin oral suspension was added to 10 1-mL samples of solutions of sodium caseinate, calcium caseinate, a mixture of sodium and calcium caseinates, and calcium chloride as well as to 10 1-mL samples of a distilled water control to produce theoretical concentrations of 10 micrograms/mL. The samples were filtered using an ultrafiltration technique and assayed for phenytoin concentration by high-performance liquid chromatography. The mean concentration of phenytoin in the filtrates of the test samples was significantly lower than the mean concentration in the control samples. The recovery of phenytoin from sodium caseinate solutions was significantly lower than that from solutions of calcium caseinate or calcium chloride. There was no significant difference between recovery of phenytoin from sodium caseinate solutions and that from solutions of sodium and calcium caseinates. Decreased phenytoin absorption from enteral nutrient solutions in vitro may be associated with the presence of caseinate salts and calcium chloride. However, this relationship cannot be extrapolated to in vivo absorption.

Calcium Chloride↗