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Biomedical subjects

O Backer

Publications and source records attributed to O Backer.

11 recordsLinked to original sources
PubMed1989

[Long-term results of ileorectal anastomosis in the treatment of ulcerative colitis].

During the period 1951 to 1987, ileorectal anastomosis in one or two seances, depending upon the activity of the disease, was carried out in 63 patients with ulcerative pancolitis. It is concluded that the operative procedure seen in relation to recent continence-retaining types of operation and despite the relatively great frequency of convertion of 20% will still constitute an alternative in surgical treatment of patients with ulcerative colitis.

Colitis, Ulcerative↗
PubMed1988

Evaluation of ileorectal anastomosis for the treatment of ulcerative proctocolitis.

Of 327 patients treated for ulcerative proctocolitis, 165 underwent surgery and an ileorectal anastomosis was performed in 59: 19 of these patients were operated upon in one stage and 40 in two stages. In 13 cases the anastomoses had to be converted, 5 during the initial hospitalization and 8 during a later admission. Three patients developed carcinoma of the rectal stump. The median follow-up period was 15 years. It is concluded that ileorectal anastomosis has a place in the treatment of inflammatory bowel disease, but requires careful follow up of the patients.

Anastomosis, Surgical↗
PubMed1985

Brown bowel syndrome.

The brown bowel syndrome (BBS) is a rare disease characterized by malabsorption and accumulation of lipofuscin in the smooth muscle cells of the muscularis externa of the small intestine. Recently, we incidentally observed a case of BBS in a colon operated on because of a neoplasm. Our ultrastructural investigation, which demonstrated changes in the mitochondria, further supports the significance of mitochondrial damage in BBS.

Adenocarcinoma↗
PubMed1981

The Copenhagen PLAFA project: a randomized trial of gastroplasty versus very-low-calorie diet in the treatment of severe obesity (preliminary results).

Consecutive patients, between 18 and 54 years, suffering from morbid obesity (greater than or equal to 60 per cent overweight) are being randomized to either gastroplasty a.m. Gomez or to a very-low-calorie diet (341 kcal, 1.43 MJ) based on a high-value protein powder with an admixture of calcium, phosphate, sodium, chloride, and magnesium. Through a supplementary daily vitamin-mineral capsule and three tablets of potassium chloride the total regime complies with the 1980 RDA. After initial hospitalization, both groups are seen as out-patients. Twenty-eight patients have so far been studied and none has dropped out. Preliminary results show a substantial weight lose without significant differences between the groups.

Clinical Trials as Topic↗
PubMed1980

Cimetidine for severe gastroduodenal haemorrhage: a randomized controlled trial.

During a period of 12 months, 88 patients with severe haemorrhage from gastric or duodenal ulcers or from erosive gastritis completed a double-blind trial of either cimetidine or placebo. Only patients needing immediate blood transfusion were admitted to the trial. It was found that in patients with severe bleeding from gastric or duodenal ulcers neither the severity of bleeding nor the incidence of emergency surgery was reduced by cimetidine. Furthermore, the treatment did not improve the mortality rate. It is concluded that patients with severe bleeding from gastric or duodenal ulcers will not benefit from immediate treatment with intravenous cimetidine.

Adult↗
PubMed1979

Meal-stimulated gastric acid and gastrin secretion before and after jejuno-ileal shunt operation in obese patients. A preliminary report.

Meal-stimulated gastric acid secretion was measured by intragastric titration before and after jejuno-ileal bypass operation in five obese patients. Acid secretion was significantly reduced after the operation, particulary during the late phase of the acid response, suggesting that stimulation of acid secretion may be elicited from the upper small intestine by a composite meal. Serum gastrin concentrations remained unchanged after the operation.

Adult↗
PubMedDate not supplied

Acute obstruction in cancer of the colon and rectum.

Results after operations for acute obstruction of the large intestine due to cancer were analyzed during a 10-year period and compared with the results after operations for nonobstructive tumors during the same period. The following conclusions could be deduced: 1) Cancer is more often obstructive in the colon than in the rectum. Cancers of the splenic flexure are relatively more often obstructive than cancers in other parts of the colon. 2) Postoperative morbidity (and probably mortality) is higher and the five-year survival shorter in patients with obstructive cancers of the large intestine than in those without obstruction. Obstructive Dukes' A tumors are very few. 3) The early morbidity and mortality after acute cecostomy are probably not higher than after acute transversostomy, if the cecostomy wound is left open. The cecostomy carries a risk of peritoneal contamination. 4) Cecostomy does not relieve obstruction in 5-10 per cent of the patients, while transversostomy seems always to be effective. Emergency exploratory laparotomy for obstructive cancer of the large bowel instead of a blind cecostomy reduces the number of patients who need two operations by 10 per cent. 5) Hernias are frequent at the sites of previous spontaneously closed cecostomies. 6) Antibiotic bowel preparation seems not to be effective shortly after decompressive colostomy.

Adult↗