[Distribution of isoantigens (HLA) in multiple sclerosis].
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Female↗
Biomedical subjects
O Baricordi
Publications and source records attributed to O Baricordi.
Dermatoglyphic studies in patients with Cooley's anemia and Cooley's trait.
The dermatoglyphic analysis of a group of Italiam patients with Cooley's anemia and Cooley's trait shows Cooley's anemia patients to undergo a significant increase of loops on fingers and a corresponding decrease of whorls. The total loops frequency correlates negatively with the ridge distribution per loop and the total ridge count is significantly decreased. The atd angles are larger. Minor changes in the distribution of patterns in the thenar and hypothenar areas are also observed. In the Cooley's trait patients, loops on fingers are more frequent than in controls, but no difference with Cooley's anemia series is observed. The above findings suggest that the gene(s) controlling loops formation in linkage disequilibrium with thalassemia mutant may have been favourably selected on the "thalassemia chromosome" in the malaria environment.
Dermatoglyphics↗
Leucocyte morphology and chromosome morphology.
The banding techniques currently employed in human cytogenetics for the identification of the individual chromosomes have been used to stain PHA lymphocytes and circulating leucocytes. The capacity of these techniques to localize singular chromosomes or chromosomal regions has been investigated. It has been observed that among the four major categories of bands (Q, G, E and R) only the quinacrine staining is informative in interphase nuclei, because of its peculiarity to stain the long arm of the Y chromosome and few other heterochromatic regions. Interphase nuclei treated according to the C-bands show the presence of several heterochromatic masses, corresponding to the centromeric areas of individual chromosomes, but as such they cannot be recognized accurately. More specific and selective techniques, like G-11 and G-Y protocols, appear to be suitable to localize the centromeric regions of chromosome no. 9 and and long arm of Y chromosome. Variation of the incubation time in the alkali-saline solutions and of pH values have proven to be appropriate for the demonstration of other heterochromatic regions in interphase nuclei and in circulating leucocytes. The "nuclear" approach to study of specific heterochromatic regions of human chromosomes may be of practical interest into the investigation of several biological problems and into the detection of individuals carrying chromosome variants.
Cell Nucleus↗