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Biomedical subjects

O Bellmann

Publications and source records attributed to O Bellmann.

At least 37 records · Page 2Linked to original sources
PubMed1982

Concentrations of placental proteins (HPL and SP1) in maternal serum throughout normal pregnancy.

Throughout 65 normal singleton pregnancies 332 blood samples were obtained and analyzed for pregnancy-specific beta 1 glycoprotein (SP1) and human placental lactogen (HPL). The measurement of SP1 in maternal serum was made using radial immunodiffusion, that of HPL by using radioimmunoassay. There was wide variation in the number and timing of blood samples obtained from patients, and therefore the results could not be used to construct a regression curve by the usual methods applied to independent measurements. Consequently only one value per patient was chosen at random as a basis for calculations. A second degree polynomial for the logarithm of the serum concentrations yielded an optimal fit for both parameters. Tolerance intervals of 90% were calculated for use in future studies.

Adult↗
PubMed1982

Measurement of Tennessee antigen, carcinoembryonic antigen, tissue polypeptide antigen and alpha-feto-protein in body fluids associated with pregnancy.

The aim of this study was to establish if the oncofetal antigens alpha-fetoprotein (AFP), carcinoembryonic antigen (CEA), tissue-polypeptide antigen (TPA), and Tennessee antigen (TAG) were present in body fluids associated with pregnancy. There antigens were measured in amniotic fluid, cord blood, and semen. In contrast to AFP, CEA, and TPA, which were found in high concentration in amniotic fluid, the TAG concentration was lower than observed in serum. In cord blood, AFP was elevated in all samples examined. CEA was elevated in 35% of the samples. TAG was normal in all 20 samples studied. Examination of semen demonstrated that TPA, CEA, and TAG were increased over normal serum values; AFP was not increased over normal serum values in the 103 samples of semen studied. The lack of increased concentrations of TAG in amniotic fluid, cord blood and serum of pregnant women provides further evidence that this antigen is distinct from CEA, AFP or TPA. The lack of AFP in semen is interesting, and requires further investigation.

Amniotic Fluid↗
PubMed1978

[Prolactin and thyrotropin after stimulation by thyrotropin releasing hormone a study under long-term administration of oral contraceptives (author's transl)].

The longtime application of oral contraceptives is assumed to elevate serum prolactin levels under non-stimulated conditions. We therefore examined whether oral contraceptives also will augment prolactin secretion after stimulation, e.g. by thyrotropin releasing hormone (TRH). After TRH stimulation the time sequence of secretion both of prolactin (HPRL) and thyroid stimulating hormone (TSH) was determined. Three groups of women were tested in a non-randomized study: group 1 without any hormonal medication (= controls), group 2 taking an oral contraceptives containing cyproterone acetate, group 3 using an oral contraceptive containing d-norgestrel. HPRL secretion was similar in all three groups, the same held true for TSH. A possible correlation between the secretion of HPRL and TSH was examined in the control group. No such correlation was found. The secretion patterns of both hormones also were different. In addition, the basic levels of both HPRL and TSH did not seem to influence the response after stimulation.

Acne Vulgaris↗
PubMed1978

[Prolactin and thyroid stimulating hormone in late pregnancy after stimulation by thyrotropin releasing hormone (author's transl)].

There is little information to what extent the secretion of prolactin (HPRL) can be stimulated in pregnancy. The effect of thyrotropin releasing hormone (TRH) on the secretion of HPRL and thyroid stimulating hormone (TSH) in late pregnancy was examined with special emphasis on the amount and time sequence of secretion of both hormones. 21 pregnant women and 20 non-pregnant women were tested by intravenous injection of 200 ug TRH. In the pregnant group the HPRL serum levels increased much more than in the non-pregnant group, however, the increase of HPRL above baseline levels expressed as percentage was lower. In contrast, TSH secretion was similar in both groups. The baseline levels of HPRL did not influence the response to the stimulus. There was no evidence for a correlation between the secretion of HPRL and TSH. The maximal increase of both hormones in serum occurred at various testpoints, however, most of the HPRL peaks preceded those of TSH. Repeating the TRH test after two or three days resulted in good reproducibility concerning HPRL secretion whereas TSH secretion was diminished.

Adult↗
PubMed1978

[Serum concentrations of prolactin, growth hormone, and alpha-fetoprotein under long-term administration of an oral contraceptive containing cyproterone acetate (author's transl)].

Serum prolactin, growth hormone, and alpha-fetoprotein were determined in women taking a new oral contraceptive, consisting of 2 mg cyproterone acetate and 50 microgram of ethinylestradiol. Because these women were suffering from acne vulgaris they were taking this contraceptive containing a gestagen with antiandrogenic activity. Prolatin and growth hormone were determined because both may favour the development and the growth of mammary tumors and because their secretion may be stimulated by estrogenic compounds. Alpha-fetoprotein is a marker of hepatocellular carcinoma, which may be associated with long-term use of oral contraceptives. During one year of treatment with cyproterone acetate and ethinylestradiol there was a continuous rise of serum concentrations of prolactin. However, this rise did not exceed the normal range. In contrast, serum concentrations of growth hormone did not change significantly. Serum alpha-fetoprotein levels remained below the detection limit of the method.

Acne Vulgaris↗
PubMed1977

[Clinical aspects and diagnosis of intrauterine growth retardation].

Low birthweight infants add to a great extent to perinatal mortality. Among this group children with intrauterine growth retardation differ from premature children with respect to their pre-, intra- and postnatal risk. Early prenatal diagnosis and monitoring is of great importance for the outcome and later development of these children.

Adult↗
PubMed1977

[A critical analysis of the present state of recognizing the fetal hazard in pregnancy, via hormonal determinations (author's transl)].

The experience published in medical literature on the pregnancy hormones HPL and estrogens, is subjected to a critical review. The reported studies are examined in detail, first of all, with regard to the performance of the pregnancy hormones in fetal risk situations, taking certain pregnancy complications into account. The ranking of these paremeters in arriving at obstetric decisions in fetal emergency situations, is then described. This is followed by an assessment of the importance of the pregnancy hormones as prognostic parameters for forecasting fetal hazard in cases where pregnancy appears to have taken an uneventful courese, basing on few results available to date. All findings indicate that biochemical monitoring during pregnancy contributes toward individualization of the obstetric decisions.

Estrogens↗
PubMed1976

In vitro studies on enzymatic cleavage of steroid esters in the female organism.

The decreasing water-solubility of steroid esters concomitant with increasing chain lenth of monocarboxylic acids provides a prolonged therapeutic effect of the steroid. Whether a slow release of the steroid from an oily depot in the muscle or a secondary storage of the enter in the body fat ("deep compartment") are responsible for this prolonged action, is open to discussion. The aim of this study was to investigate the steriod ester cleaving enzyme activity of human subcutaneous fatty tissue. The followeing steroid esters were investigated: Testosterone acetate and oenanthate, metenolone acetate and oenanthate, norethisterone acetate and oenanthate, dehydroepiandrosterone acetate and oenanthate, fluocortolone acetate and caproate. In the 10000 X g supernatant phase of the female subcutaneous fatty tissue the rate of enzymatic cleavage of the long-chain oenanthates was considerably greater than that of the corresponding short-chain steroid esters. The nature and position of the ester group in the steroid molecule exhibited a marked effect on the rate of enzymatic cleavage of steroid esters. The cleavage rate of long- and short-chain steroid esters in human myometrium and endometrium resembled that in the fatty tissue. On the other hand, the gastric mucosa, recuts musculature, placenta and vaginal mucosa split the short-chain steroid esters more rapidly than the long-chain esters. The marked differences in the relation of the cleavage rate of long- and short-chain steoid esters in the various tissues allow the assumption that long- and short-chain steroid esters are cleaved by different enzymes.

Adipose Tissue↗