[PET--options and limitations].
Explore the source record for details and available documents.
Fluorodeoxyglucose F18↗
Biomedical subjects
O Belohlávek
Publications and source records attributed to O Belohlávek.
Metabolic characterisation of solitary pulmonary nodules by positron emission tomography with FDG--preliminary report.
BACKGROUND: In the past some authors evaluated FDG-PET as a powerful tool for non-invasive assessment of malignancy of solitary pulmonary nodules (SPN). The aim of this paper is to verify the performance of positron emission tomography with fludeoxyglucose (FDG-PET) in SPN in the conditions of the Czech Republic during the first 16 months of the operation of the PET Centre Prague. MATERIAL AND METHODS: The group of 22 patients with 23 SPN was investigated by dedicated PET scanner due to inconclusive CT scan. Micromorphological confirmation was available in 61%; follow-up (median = 12 months) concerned the other 39% SPN. RESULTS: PET was clearly positive in 11 nodules, all were malignant according to micromorphological assessment. PET was completely negative in 10 nodules, 3 of them were micromorphologically evaluated as benign, the other 7 nodules were followed up without any signs of malignancy. In two cases, PET revealed enhanced glucose consumption, but the pattern was not typical for malignancy. These cases were considered as bronchopneumonia, but till now, they have not been definitely resolved. CONCLUSIONS: Excluding two unresolved cases, sensitivity and specificity of FDG-PET was 100% for malignancy in our series. PET was helpful in medical decision-making in all patients.
Journal Article↗
Personal dosimetry in the PET Centre Prague.
This work is focused on radiation protection in the PET Centre Prague. The personal year dose equivalents of physicians, technologists and lab-technologists in the period 1997-2000 are presented. Dose equivalents are listed for each group as collective, mean and maximum dose equivalents and number of people in the evaluated group. There is an increase in the dose equivalents in 1999 when the PET scanner was installed. Later on, when personnel was trained and better local shielding was used, the increase is not much higher even though the number of patients investigated per day doubled. The radiation field measurements showed that the radiation dose equivalent rate outside the controlled area is on the background level of about 0.17-0.18 mSv/hour.
Journal Article↗
Introducing the PET Centre Prague.
The PET Centre Prague (www.homolka.cz/nm) was established in 1999 as the outcome of a joint project of the public Na Homolce Hospital and the Nuclear Research Institute Rez, plc, the Czech radiopharmaceutical producer. Technical and financial assistance was provided by the International Atomic Energy Agency, which perceived the Centre as its model project that could serve as a guide for the development of PET centres in countries sharing a comparable level of development with the Czech Republic. The article maps the history of the project, its design, workplace lay-out and equipment, radiation protection arrangements and spectrum of the first approx. 3,000 investigations.
Journal Article↗
Attenuation correction stress myocardial SPECT: possibility of reduction in number of rest investigation.
BACKGROUND: Attenuation-corrected (AC) imaging frequently shows normal stress myocardial perfusion while non-corrected (NC) imaging shows hypoperfusion. The aim of the work was to assess whether it is necessary to continue with resting examination in this situation. MATERIAL AND METHODS: 121 consecutive patients had positive finding at AC and/or NC sestamibi stress myocardial imaging using E.CAM Profile system and resting examination was carried out. AC stress imaging was normal while NC imaging showed hypoperfusion in 29 cases. In one case this finding was reversed. In this group of 30 patients with AC/NC stress discrepancies, resting examination has not revealed any additional information in 28 cases. RESULTS: In 2 cases NC imaging, in contrast to AC, showed stress ischaemia. In one of these 2 cases coronarography was carried out with negative result. In the other case patient refused coronarography. CONCLUSIONS: The resting examination did not bring any benefits in 29-30 cases out of 30 (96.7 to 100.0%) patients with AC/NC stress discrepancies. If the results of this study are considered accordingly, in our group approximately one fourth of the resting examinations (29 to 30 out of 121) could be saved.
Journal Article↗
Brain studies--image co-registration and template creation.
Image co-registration requires special software, which is usually available for Unix workstations. This work presents two programs running under MS Windows, one for study co-registration and one for template creation. The co-registration can be done by minimising/maximising the count difference, squared difference, shape and mutual information. The quality of the fit can be estimated by evaluating the contours with different tools. The aligned images can be used for template creation. Both programs can be downloaded from http://www.homolka.cz/nm.
Journal Article↗