Biomedical subjects
Publications and source records attributed to O Brandonisio.
In sera of 35 dogs with generalised leishmaniasis elevated levels of circulating immune complexes were detected by the 125I-C1q binding test. Furthermore, anti-heart muscle and anti-smooth muscle antibodies were detected by an indirect immunofluorescence technique in sera of infected dogs.
The causes of the loosening of a hip prosthesis may be inflammatory, mechanical, immunitary or due to detritus. A bacteriological and histological study, in cases where further surgery was needed, may clearly contribute to the aetiopathogenesis of failure. Loose hip prostheses removed at operation were studied from a bacteriological and, in particular, histological point of view. There results were then correlated to clinical, radiographic and laboratory data obtained during follow-up. Inflammation proved to be a constant histological finding. The hyalinosis observed in 22 cases revealed significant analogies with histological pictures of silicotic granuloma, for which an immunitary pathogenesis is the current hypothesis. Thus, it is our belief that this correlation is suggestive of an immunitary based approach in cases where hip prostheses fail due to loosening.
A case of cryptosporidiosis in a male homosexual man with AIDS is reported. The clinical manifestations were anorexia, mild fever, abdominal pain and profuse watery diarrhea. The diagnosis was made in fecal smears by using a modified Ziehl-Neelsen method and a safranin-methylene blue staining technique.
Fifteen dogs with generalised leishmaniasis have been evaluated for their monocyte capacity to ingest Leishmania promastigotes. These cells displayed a lower phagocytic ability when compared to monocytes recovered from normal dogs. Moreover, sera from Leishmania-infected dogs caused a remarkable decrease of monocyte phagocytic ability in healthy dogs, whereas sera from healthy dogs could restore monocyte phagocytosis in sick animals. Similar results were seen when Candida albicans was used as stimulant. Interestingly, supernatants from polyethylenglycole (PEG) treated sera from Leishmania-infected dogs did not inhibit monocyte phagocytosis either in the autologous or in the homologous (healthy dogs) system. This suggests a possible role for serum factor(s) in the impairment of phagocytosis in Leishmania infection.
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175 sera from children and 101 sera from adults both with respiratory illness of unknown origin were collected between September 1980 and February 1983 and studied by using the indirect immunofluorescence test for Legionnaires' disease. By using the criteria of the Center for Disease Control for a positive (fourfold increase in titer over 128 during convalescence) or presumptive (single titer greater than or equal to 256) serological test, 8 samples from adults (7.92%) and 11 samples from children (6.27%) gave a positive result. These results suggest that the frequency of Legionnaires' disease is similar in both adults and children.
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Among several children admitted in Hospital with febrile acute pneumonia, it has been found - by indirect immunofluorescence assay a significant seroconversion for Legionella pneumophila serogroup 1, compatible with a recent infection, in an 18-month-old boy. The clinical course of the disease was favourable, and a prompt recovery as observed after administration of an antibiotic (cefuroxime) stable to the bacterial beta-lactamase.
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After some notices on the Limulus amebocyte lysate test the AA. expose the results of an investigation for in vitro pyrogen detection in parenteral preparations.
Some culture filtrates or enterotoxin preparations from enterobacteria that activate the adenylate cyclase system (vibrio cholerae, LT fraction from escherichia coli and klebsiella pneumoniae, shigella dysenteriae type 1) exibit an inhibiting effect on ADP-induced platelet aggregation, while other enterotoxin preparations not effective on adenylate cyclase system, don't interfere with this model. The A. propose the platelet aggregation as cellular assay to detect enterotoxin fractions effective upon adenylate cyclase system.
The Authors on the basis of most recent references, expose the epidemiological, cultural, biochemical and taxonomical characteristics of microorganisms of the genus Serratia. In addition the most recent data regarding the typing and the sensitivity to antibacterial agents are discussed.
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