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O Buresova

Publications and source records attributed to O Buresova.

5 recordsLinked to original sources
PubMed1991

Brain stem mechanisms of conditioned taste aversion learning in rats.

Acquisition of conditioned taste aversion (CTA) in rats is not prevented by functional decortication, anesthesia or hypothermia applied after intake of the flavored fluid and maintained throughout the action of the poison but is disrupted by bilateral application of 10 ng tetrodotoxin (TTX) into the parabrachial nuclei. The blockade is directly proportional to TTX dosage, indirectly proportional to distance of the injection site from parabrachial nuclei and equally affects CTAs using different CS (saccharin, NaCl) and different US (LiCl, carbachol, amphetamine, cycloheximide). CTA is disrupted by TTX applied up to 4 but not 8 days after a single CS-US pairing. TTX fails to disrupt overtrained CTA and elicits only a weak anterograde amnesia when applied 1 but 2 or more days before CTA acquisition. It is concluded that the parabrachial nuclei and the adjacent reticular formation probably represent the neural substrate of the permanent CTA engram the protracted consolidation of which is disrupted by prolonged cessation of impulse which is disrupted by prolonged cessation of impulse activity in the information storing network.

Amnesia↗
PubMed1989

Conditioned taste aversion to injected flavor: differential effect of anesthesia on the formation of the gustatory trace and on its association with poisoning in rats.

Anesthesia disrupts formation of conditioned taste aversion (CTA) when induced before presentation of the gustatory stimulus but does not prevent association of the already formed gustatory trace with delayed poisoning. The transition between the disruption-prone and disruption-resistant phases of CTA acquisition was examined under conditions eliminating the confounding effect of anesthesia on ingestive behavior. Intraperitoneal injection of 2% saccharin (1% b.wt.) was used as an intravascular gustatory conditioned stimulus (CS) followed 2 h later by the visceral unconditioned stimulus (US) (LiCl 0.15 mol/l, 2% b.wt.). Pentobarbital anesthesia (50 mg/kg) prevented CTA formation when applied 4 h before to 30 min after saccharin injection, but was ineffective in the second half of the CS-US interval (1-2 h after saccharin administration). CTA acquisition was also impaired by subanesthetic dosages of pentobarbital (10 and 20 mg/kg) preceding i.p. injection of saccharin. It is concluded that the abrupt disappearance of the disruptive effect of pentobarbital in the middle of the CS-US interval marks the formation of the gustatory trace which mediates CTA learning even when both CS and US are applied by i.p. injection.

Anesthesia↗
PubMed1983

Cortical spreading depression and conditioned taste aversion: an attempt to resolve a controversy.

The claim (Winn, Todd, & Elias, Behav. Biol. 19, 55-63 (1977) ) that cortical spreading depression (CSD) can serve as US in the conditioned taste-aversion (CTA) paradigm was experimentally examined. Rats given 15-min access to novel 0.1% sodium saccharin (CS) followed by ip NaCl and bilateral or unilateral CSD (US) displayed similar saccharin preference (54%) as the sham-CSD-treated controls in a multiple-bottle retention test. Rats receiving ip LiCl (0.15 M, 2% body weight) and sham CSD as the US showed marked saccharin aversion. It is concluded that CSD does not elicit CTA and that some claims to the contrary can perhaps be ascribed to CSD-induced disruption of attenuation of neophobia.

Animals↗