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Biomedical subjects

O C Barreto

Publications and source records attributed to O C Barreto.

6 recordsLinked to original sources

[Hair transplantation. Past, present, and future].

This paper briefly reflects the author's ideas regarding hair transplantation based on 25 years of experience in this field. Hair transplantation is a technique that moves hair from the donor dominant scalp to the recipient scalp with a variety of methods and protocols. The first written report on this surgical art form was made by Sasgawa in 1930, who described an insertion technique. Okuda later wrote about punch autografts and homografts in humans and animals in 1939; after which time Tamura and Fujita demonstrated reconstructive techniques with small grafts. However, it was not until 1959 that modern-day hair transplantation began, when Orentreich published a paper describing the theory of donor dominance. Recently, the advent of mini- and micrografts has indeed refined the technique, especially in those with early alopecia, in women and in facial scar alopecias.

Female↗

Snakebite-induced acute renal failure: an experimental model.

Acute renal failure (ARF) has been frequently reported after bites from the Viperidae snake family. The lack of a reproducible animal model has hampered the study of renal damage mechanisms. Intravenous injection of rats with 0.4 mg/kg of Bothrops jararaca venom produced functional and morphologic changes similar to those observed in human snakebite-induced ARF. There was an acute and significant decrease in the glomerular filtration rate, diuresis, and renal plasma flow. Serum fibrinogen levels decreased significantly. There was intravascular hemolysis, as shown by a significant decrease in hematocrit, and an increase in plasma lactate dehydrogenase levels and free hemoglobin. Blood pressure and serum creatine phosphokinase levels were not affected. Light and electron microscopy showed massive fibrin deposition in glomerular capillaries, proximal and distal tubular necrosis, and hemolyzed red blood cell casts in renal tubules. Based on these findings, a model of snakebite-induced ARF was achieved. Ischemia related to glomerular coagulation and intravascular hemolysis were the most important pathogenic factors causing a decrease in the glomerular filtration rate, although a direct venom nephrotoxicity cannot be excluded.

Acute Kidney Injury↗

[Glucose-6-phosphate dehydrogenase deficiency with recurrent infections: case report]

OBJECTIVE: To report a case of rare neutrophil functional disorder with clinical and laboratory findings similar to those of chronic granulomatous disease. METHODS: Patient with extremely reduced level of glucose-6-phosphate dehydrogenase and recurrent infections that improved after continuous use of cotrimoxazole. The patient presented leukocytes with defective respiratory burst, similar to what occurs in chronic granulomatous disease. COMMENTS: The diagnosis of glucose-6-phosphate dehydrogenase deficiency in neutrophils should be considered in any patient with hemolytic anemia whose level of G6PD is extremely low or in any patient that presents recurrent infections as differential diagnosis of chronic granulomatous disease.

Journal Article↗