Biomedical subjects
Publications and source records attributed to O Cervetti.
The Authors describe a clinical case of a 60 year old man with cervico-facial actinomycosis. The histology, the differential diagnosis and the successful penicillin therapy are also discussed.
The Authors describe a case of a 65 year-old man with paraneoplasic syndrome, presenting erythematous-edematous figure lesions. Clinical, histological and immunological features were suggestive of lupus erythematosus.
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The presence of candida and other fungi was investigated in 300 patients referred with anal problems of diverse aetiology. Candida was present in 13% and played a pathogenic role in about 50% of all positive cultures. It is concluded that cultural tests for fungal pathogens should always be performed in cases of anal itching or burning combined with other anal skin problems.
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Ketoconazole is a new antifungal drug, used for oral treatment, with a broad spectrum of activity. It is a member of the imidazole series and is active in superficial and deep mycotic diseases, in candidosis and pityriasis versicolor. This new imidazole derivative has been successfully administered in several cases of dermatophytosis, yeasts and pityriasis versicolor in the authors' clinic, as well as in many other research centres. Treatment has been given to patients with tinea corporis, tinea cruris, tinea pedis, with or without location in interdigital spaces, while the cases of tinea capitis are still under investigation. The following variants of candida infections have been treated: onychomycosis, intertrigo and mucocutaneous candidosis due to prolonged immunosuppressive therapy. No remarkable haematochemical disorders have been observed after treatment.
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The study here presented deals with the problem of the dermatophytoses in Piedmont, with regard to their etiologic and, more generally, their epidemiologic aspects. From 586 patients who presented themselves at the Dermatology Clinic of the University of Turin, for mycological examinations, between the period of March-November 1979, 100 positive cases were selected. The study was set under way with the filling in of special forms for the epidemiologic investigation and with the classification of some species of fungi which had been isolated beforehand, using the methods of Ajello, Rebell and Taplin (1, 12). From the data collected, it was ascertained that the principal etiologic agents isolated were, in order of frequency: Microsporum canis, Tricophyton rubrum, Epidermophyton floccosum and T. mentagrophytes. The subjects that were affected most by these dermatophytes were the young (babies and schoolchildren) with the location of the infections being mostly in the scalp. As regards the period of manifestation, May - June and September - October were the periods with the highest incidence. It is noteworthy that the diffusion of the principal dermatophytes could be attributed to domestic animals such as cats and dogs.
After discussing the classification of the Actinomycetales, the authors give a detailed description of the epidemiology and particularly of the clinical features of cutaneous diseases induced by genera such as Actinomyces, Norcardia and Streptomyces. Histopathological and immunological studies, together with laboratory and differential diagnostics, are also examined. In the last section, present therapeutic treatments are briefly outlined.
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