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Biomedical subjects

O Colombo

Publications and source records attributed to O Colombo.

11 recordsLinked to original sources
PubMed1997

[Central obesity: relationship between conicity index and lipoprotein risk factors for coronary atherosclerosis].

In middle age men the relationship between biochemical and anthropometric parameters was studied associated with central obesity in order to evaluate the risk of coronary atherosclerosis. In 31 males of 30 to 65 years of age, "apparently healthy", we determined the percentile 50 (P50) for body fat percentage (PG), 26.8% (utilizing the skinfold thicknesses) and P75 of Conicity Index (IC), 1.26. Were selected 63 subjects with different values of PG and IC. IC, adjusted for BMI and PG, correlated with Cholesterol (CT), Triglycerides (TG), CT/C-HDL, C-LDL/C-HDL, Apolipoprotein B (ApoB), Apo B/C-HDL, (P < 0.01) in all cases), and cholesterol LDL (C-LDL) (P < 0.05). This population was divided in three groups: Group I, Control, N = 19, PG < = 27% and IC < 1.26; Group II, obese without Central Obesity Predominance (POC), N = 15, PG < or = 27% and IC < or = 1.26; Group III, N = 23, obese with POC, PG > 27% and IC < or = 1.26. We found that Group III vs Group II had: CT 242 +/- 35 vs 205 +/- 40 mg/dl (P < 0.01), C-LDL 165 +/- 41 vs 138 +/- 36 mg/dl (P < 0.05) and CT/C-HDL 6.0 +/- 1.2 VS 5.1 +/- 1.2 (p < 0.05) respectively. Group III vs I showed significant differences for all biochemical parameters and index studied with exception of C-HDL. In subjects with IC > 1.26 vs IC < = 1.26 increased the frequency of coronary risk factors and indicators: CT > or = 240 mg/dl, 59% vs 12% (P < 0.001); C-LDL > or = 160 mg/dl, 55% vs 18% (P < 0.001); Apo B > 120 mg/dl, 72% vs 26% (P < 0.001); CT/C-HDL > 4.5, 86% vs 53% (P < 0.01); C-LDL/C-HDL > 3.0, 86% vs 47% (P < 0.001); Apo B/C-HDL > 2.6, 72% vs 47% (P < 0.05). Our results suggest that the use of IC combined with lipoproteic factors and index will contribute to the detection of males at risk of coronary heart disease.

Adult↗
PubMed1994

[Risk factors for coronary atherosclerosis. Comparison between two Argentine regions].

The prevalence of risk factors for coronary atherosclerosis were studied in two population samples, Northeast (Posadas, n = 498) and South (Viedma, C. Rivadavia and Cipolletti, n = 652) of 20 years and older, males and females. The diet in the Northeast (n = 102) contained more monounsaturated acids and polyunsaturated acids than the one in the South (n = 62), 9.5 +/- 4.1 vs. 8.1 +/- 3.5% TCV (Total Caloric Value) (P < 0.02) and 8.1 +/- 4.1 vs. 6.2 +/- 3.0% TCV (P < 0.001) respectively. The P/S relationship was greater in the Northeast, 1.02 +/- 0.44 vs. 0.85 +/- 0.50 (P < 0.001). Total cholesterol (TC) in the Northeast was less than in the South, in males 176 +/- 41 vs. 213 +/- 43 mg/dl (P < 0.001); CLDL (LDL cholesterol) 109 +/- 37 vs. 141 +/- 41 mg/dl (P < 0.001). The most frequent risk factors in the South vs. Northeast (males) were: TC > or = 240 mg/dl, 26.7% vs. 9.5% (P < 0.001); LDL-C > or = 160 mg/dl, 30.3% vs. 10.9% (P < 0.001); Cig > or = 10/d (equal or more than 10 cigarettes per day), 30.0% vs. 16.4% (P < 0.001). The hypertension prevalence (HTA, 160/95), in males, was higher in the Northeast than in the South, 23.7% vs. 11.5% (P < 0.001). BMI > 27 Kg/m2 was higher in the women of Northeast than in the South, 38.4% vs. 24.2% (P < 0.001). In the males of the Northeast, the combination Cig > or = 10/d and HTA, 4.1 vs 0.9% was more common; in the South Cig > or = 10/d and LDL-C > or = 160 mg/d, 8.2% vs. 1.8% (P < 0.001) was more common. The differences in the prevalence of the risk factors between the population samples indicate the need to plan the prevention of coronary atherosclerosis locally.

Adult↗
PubMed1993

[Diet as a risk factor for coronary atherosclerosis in a rural area of Argentinian Patagonia. Comparison with the urban zone of Viedma].

To determine risk factors, a clinical, cardiologic, biochemical and nutritional study was carried out. A sample of the rural population of Comi-Co (N = 92), which included descendants of Mapuche indians, was compared with a sample of the urban population of Viedma (N = 94). Sheep, goat and horse meat from the rural district was analyzed. In horse meat, intramuscular fat was 1.16 g%, with 34.5% of polyunsaturated fatty acids including linolenic (18:3 w3) 11.9%, linoleic (18:2 w6) 21.0%. The diet intake of the rural population was very different from that of the urban population (p < 0.001). It contained 3420 +/- 1027 vs 2110 +/- 654 kcal, carbohydrates 40 +/- 8 vs 55 +/- 10%, lipids 33 +/- 5 vs 24 +/- 8%, proteins 28 +/- 6 vs 20 +/- 6%, cholesterol 1021 +/- 380 vs 385 +/- 156 mg/day. The rural population showed a tendency to suffer cholelithiasis. Comi-Co vs Videma males had a CHDL 53 +/- 13 vs 47 +/- 9 mg/dl (p < 0.05) and no significant differences were found between both groups when it came to blood glucose, uric acid, triglycerides and Apo B. The frequency of individuals with CT > or = 240 mg/dl, CLDL > or = 160 mg/dl, cigarettes > or = 10/day seems to be less in the rural district. In Viedma vs Comi-Co males, with any one primary factor there was a ratio of 45% vs 24% (p < 0.05). The proportion of males with two risk factors was low. No individuals with three risk factors were found.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1985

Effects of diabetes, beta-hydroxybutyric acid and metabolic acidosis on the pituitary-thyroid axis in the rat.

Previous studies demonstrated alterations of thyroidal economy in untreated diabetes mellitus both in man and experimental animals. To test the role of beta-hydroxybutyric acid (BHB) and acidosis in generating such changes, we studied the pituitary-thyroid axis of streptozotocin-diabetic rats, BHB or ammonium chloride (NH4Cl)-treated normal rats. Serum TSH, pituitary content and pituitary concentration of TSH, serum T4, T3 and free T4 (FT4), were all measured by RIA. In short term (2 days) diabetic rats the pituitary content of TSH was normal whereas the concentration (per mg of protein) was elevated (p less than 0.05 versus control group). Serum TSH (p less than 0.05), serum T4 (p less than 0.05), serum T3 (p less than 0.01) and serum FT4 (p less than 0.05) were all significantly decreased. In long term (30 days) untreated diabetic rats serum changes were similar to the short term diabetic group, though the pituitary content of TSH was significantly decreased (p less than 0.05). Animals treated with NH4Cl had no variations from controls. However, rats treated with BHB displayed a significant decrease in pituitary content of TSH (p less than 0.05), pituitary concentration of TSH (p less than 0.05) and in plasma TSH (p less than 0.01), and normal thyroid hormones in serum. No significant changes were seen in the TSH response to TRH in 2 or 30 days untreated diabetic and in BHB - treated animals. The data suggest that BHB, although not NH4Cl acidosis, may be capable of inducing a moderate depression of pituitary and plasma TSH of a lesser magnitude of that accompanying the full, long term diabetic state in the rat.

3-Hydroxybutyric Acid↗