Phosphomonoesterases of Schistosoma mansoni.
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Biomedical subjects
Publications and source records attributed to O D STANDEN.
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The effects on activity against Schistosoma mansoni of further modifications of the diaminodiphenoxyalkanes are reported. Replacement of the amino-group by any of a large number of other groups destroys activity. Activity is retained in the presence of certain substituted (hydroxyalkyl, carboxyalkyl) amino-groups and in some of their aldehyde-bisulphite derivatives. Many variations of the central chain lead to compounds of reduced activity, the outstanding exceptions being a number of but-2-ene derivatives, which retain full activity.
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