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Biomedical subjects

O Donatsky

Publications and source records attributed to O Donatsky.

At least 19 recordsLinked to original sources
PubMed1997

Computerized cephalometric evaluation of orthognathic surgical precision and stability in relation to maxillary superior repositioning combined with mandibular advancement or setback.

PURPOSE: A computerized, cephalometric, orthognathic surgical program (TIOPS) was applied in orthognathic surgical simulation, treatment planning, and postoperatively to assess precision and stability of bimaxillary orthognathic surgery. PATIENTS AND METHODS: Forty consecutive patients with dentofacial deformities requiring bimaxillary orthognathic surgery with maxillary superior repositioning combined with mandibular advancement or setback were included. All patients were managed with rigid internal fixation (RIF) of the maxilla and mandible and without maxillomandibular fixation (MMF). Preoperative cephalograms were analyzed and treatment plans produced by computerized surgical simulation. Planned, 5-week postoperative and 1-year postoperative maxillary and mandibular cephalometric-positions were compared. RESULTS: In the mandibular advancement group, the anterior maxilla was placed too far superiorly, with an inaccuracy of 0.4 mm. The posterior maxilla and the anterior mandible were placed in the planned positions. The lower posterior part of the mandibular ramus was placed too far anteriorly, with an inaccuracy of 2.0 mm. However, the mandibular condyles were accurately placed. In the setback group, the anterior maxilla was placed too far superiorly and posteriorly, with a vertical and sagittal inaccuracy of 1.0 mm and 0.7 mm, respectively. The posterior part of the maxilla was placed in a posterior position with an inaccuracy of 1.9 mm. The anterior mandible was placed too far anteriorly with an inaccuracy of 0.9 mm. The lower posterior part of the mandibular ramus was placed in a posterior position with an inaccuracy of 0.9 mm. However, the mandibular condyles were accurately placed. The statistical analysis of the 1-year stability data showed that the maxilla had moved 0.3 mm posteriorly in the advancement group and the lower incisors had moved 0.8 mm superiorly. No other significant positional maxillary or mandibular changes were found. In the setback group, the maxilla had moved 0.5 mm posteriorly, the anterior mandible 0.5 mm anteriorly, and the lower incisors 0.7 mm superiorly. No significant positional changes were seen in the mandibular ramus. CONCLUSION: The TIOPS computerized, cephalometric, orthognathic program is useful in orthognathic surgical simulation, planning, and prediction, and in postoperative evaluation of surgical precision and stability. The simulated treatment plan can be transferred to model surgery and finally to the orthognathic surgical procedures. The results show that this technique yields acceptable postoperative precision and stability.

Adolescent↗
PubMed1996

Non-submerged osseointegrated dental implants with ball attachments supporting overdentures in patients with mandibular alveolar ridge atrophy. A short-term follow-up.

Non-submerged, hollow screw ITI-Bonefit dental implants with ball attachments supporting overdentures were used as alternative treatment to combined vestibulo-lingual-plasty with free split-thickness skin graft and removable dentures in 40 consecutive patients with mandibular alveolar ridge atrophy. One hundred and fifty-six non-sub-merged fixtures were installed. Ball attachments were mounted on the fixtures and implant-supported overdentures inserted 3-4 months after fixture installation. The observation period after implant activation and prosthesis insertion varied from 1 to 3 years with a median observation period of 2 years. The overall success rate of individual implants was 99%(155/156). The prosthesis function rate was 100%(40/40). The 1-year success rate of individual implants was 99%(155/156) with a prosthesis function rate of 100%(40/40). No persistent surgical, periodontic or prosthodontic complications were observed. The results indicate that non-submerged osseointegrated ITI-Bonefit dental implants with ball attachments supporting overdentures can be a successful alternative to combined vestibulo-lingual-plasty with free split-thickness skin graft and removable dentures, and as successful as the use of submerged dental implants.

Aged↗
PubMed1994

Precision of orthognathic surgery. A computerized cephalometric analysis of 27 patients.

The precision of orthognathic surgery was evaluated in 27 patients. Rigid internal skeletal fixation was used without intermaxillary fixation. A computerized cephalometric program package (TIOPS) was utilized in the preoperative analysis, surgical planning, and postoperative examination. The mean positional difference of the cephalometric landmarks between planned and observed outcome ranged from -0.4 to 0.7 mm. Only one reference point (pm) differed statistically significantly from the plan (P = 0.02). All other mean differences in point location were of a magnitude that was not statistically different from zero (P > 0.05). It was concluded that no systematic sources of error could be demonstrated. However, the range of random variation in the individual cases left room for considerable improvement.

Adult↗
PubMed1993

Osseointegrated dental implants with ball attachments supporting overdentures in patients with mandibular alveolar ridge atrophy.

Brånemark dental implants with ball attachments supporting overdentures were used as alternative treatment to combined lingual-vestibuloplasty with free split-thickness skin graft and removable dentures in 25 consecutive patients with mandibular alveolar ridge atrophy. Ninety-three fixtures were placed. Ball attachments were mounted on the fixtures, and implant-supported overdentures were inserted 3 to 4 months after fixture placement. The observation period after implant activation and prosthesis insertion varied from 12 to 27 months with a median observation period of 18 months. The overall success rate of individual implants was 97% (90/93). The prosthesis function rate was 100% (25/25). The 1-year success rate of individual implants was 98% (91/93) with a prosthesis function rate of 100% (25/25). No persistent surgical or prosthodontic complications were observed. Preliminary results indicate that osseointegrated Brånemark dental implants with ball attachments supporting overdentures can be a successful alternative to combined lingual-vestibuloplasty with free split-thickness skin graft and removal dentures in patients with denture problems related to mandibular alveolar ridge atrophy.

Aged↗
PubMed1992

Computerized cephalometric orthognathic surgical simulation, prediction and postoperative evaluation of precision.

A new computerized, cephalometric, orthognathic surgical program (TIOPS) has been evaluated in surgical simulation, prediction and postoperative assessment of precision. Records of 10 consecutive patients admitted for orthognathic surgical treatment were analysed and prediction plans produced by computerized surgical simulation. Predicted and postoperative positions of maxilla and mandible were compared with linear and angular measurements. No statistically significant differences between predicted and postoperative positions could be demonstrated (p greater than 0.05).

Adolescent↗
PubMed1983

Effect of zendium toothpaste on recurrent aphthous stomatitis.

A double-blind clinical trial with cross-over was conducted for a period of 12 months in 25 patients with recurrent aphthous stomatitis (RAS). The effect of the amyloglucosidase and glucoseoxidase containing Zendium toothpaste on the discomfort, number of exacerbations, duration of exacerbation, number of ulcers and number of days with pain caused by RAS was studied. The use of Zendium significantly reduced the sensation of discomfort from RAS as compared to the use of placebo toothpaste (0.025 greater than p greater than 0.01). However, the patients were unable to discriminate significantly between Zendium and placebo when asked to choose one of the toothpastes (0.10 greater than p greater than 0.05) and no significant differences were demonstrated as far as the above mentioned parameters of disease severity were concerned. Therefore, it is concluded that the reducing effect of Zendium containing amyloglucosidase and glucoseoxidase on RAS is weak as compared to a similar toothpaste without these enzymes.

Adolescent↗
PubMed1982

Effect of Saliment on parotid salivary gland secretion and on xerostomia caused by Sjögren's syndrome.

The stimulatory effect of a recently introduced saliva substitute (Saliment) on the parotid salivary secretion was experimentally investigated in 10 healthy individuals without signs or symptoms of xerostomia and in 11 patients with xerostomia due to Sjögren's syndrome. Further, in 15 patients with Sjögren's syndrome, the effect of Saliment on the sensation of xerostomia was examined in a double-blind clinical study with cross-over. The use of Saliment was followed by a significant stimulation in the parotid salivary secretion (P less than 0.01) and the subjection sensation of xerostomia was significantly reduced (P less than 0.01).

Adolescent↗
PubMed1980

Recurrence of the odontogenic keratocyst in 13 patients with the nevoid basal cell carcinoma syndrome. A 6-year follow-up.

A 6-year follow-up study of 44 primarily enucleated odontogenic keratocysts from 13 patients with the characteristics signs and symptoms of the nevoid basal cell carcinoma syndrome (NBS) is presented. The 2-, 3-, 4-, 5- and 6-year follow-ups revealed an incidence of recurrence by the single keratocyst of 20, 30, 39, 50 and 55%, respectively. These figures demonstrate that the majority of the recurrences occurred within a period of 5 years postoperatively. However, as the proportion of increased recurrence in the period from 5 to 6 years postoperatively was 5%, a follow-up period of more than 6 years is necessary in order to make the diagnosis of recurrence without any delay in all patients with NBS. The occurrence of odontogenic epithelium and/or microcysts in the cyst wall of keratocysts without any recurrence at the 5-year follow-up was compared with the occurrence of similar histopathologic features in keratocysts which at the 5-year follow-up had shown recurrence. The occurrence of odontogenic epithelium and/or microcysts was demonstrated in 43% of the group of keratocysts without recurrence and in 57% of the group of keratocysts with recurrence. However, this difference is not statistically significant (P > 0.10) and indicates that the high occurrence (50%) of odontogenic epithelium and/or microcysts in NBS-keratocysts is not significantly correlated to the recurrence.

Adult↗
PubMed1980

Oral health status and treatment needs in long-term medicine patients in a Copenhagen hospital department.

Oral health and dental treatment needs were investigated in 50 randomly selected long-term medicine patients admitted to The Glostrup Hospital, University of Copenhagen, Glostrup, Denmark. All the patients were clinically and radiologically examined. Oral health generally was poor. Two-thirds (66%) of the patients were totally edentulous, 24% partially edentulous. Only 10% were dentate with no dentures. The number of remaining teeth per patient averaged 4.7, that of caries destructed teeth 1.4. All 17 patients with remaining teeth had periodontal disease, and 13 of them suffered from caries. Alveolar ridge atrophy, periapical inflammation, root remnants, impacted teeth and oral mucosal lesions were demonstrated in, respectively, 80, 22, 24, 8, and 26% of the group. In total 82% of the patients needed some kind of treatment, mainly prosthetic and oral surgery. The estimated total treatment time per patient averaged 165 min.

Adult↗
PubMed1980

An immunoelectrophoretic analysis of the Strep. sanguis and adult human oral mucosa antigen extracts used for immunological investigations of recurrent aphthous stomatitis.

Water-soluble antigens of Strep. sanguis strain 2A, ATCC 10556, and adult human oral mucosa (AHOM) were analysed by four immunoelectrophoretic methods. Crossed immunoelectrophoresis (CIE), using rabbit antibodies raised against the soluble antigens, revealed 26 antigens in the standard Strep. sanguis antigen extract and 16 antigens in the standard adult human oral mucosa extract. All 26 Strep. 2A antigen-antibody precipitates observed in the CIE were identified as streptococcal components. Eleven of the AHOM antigen-antibody precipitates in the CIE were derived from human serum proteins and hemoglobin present in the crude AHOM-Ag extract. Five of the latter precipitates possibly were caused by oral mucosal antigens. The AHOM-Ag extract contained four bacterial contaminants. None of them influenced the crossed immunoelectrophoretic AHOM antigen-antibody reference pattern in the present study.

Adult↗
PubMed1977

Deposits of immunoglobulin G and complement C3 in recurrent aphthous ulcerations.

Deposits of immunoglobulin G (IgG) were demonstrated at the basement membrane zone in lesions from 14 out of 16 patients with recurrent aphthous ulcerations (RAU) by means of an immunofluorescent (IF) staining technique. Deposits of complement C3 were demonstrated at the same localization in lesions from 16 out of 16 patients with RAU. Similar deposits of C3 were demonstrated in 11 out of 12 experimentally produced oral wounds (EOW). Immunoglobulin deposits were not detected in the EOW. No deposits of immunoglobulin or C3 were revealed in 12 biopsies from normal oral mucosa (NOM). Further, the IF investigation demonstrated circulating autoantibodies against the cytoplasm of autologous oral epithelial cells in patients with RAU. The specificity of the present immunologic reactions and their possible role in the pathogenesis of RAU are discussed.

Adult↗
PubMed1977

Microorganisms in recurrent aphthous ulcerations.

Qualitative and quantitative examinations of the cultivable bacterial flora in biopsies from recurrent aphthous ulcerations (RAU), experimental oral ulcerations (EOU), and normal oral mucosa (NOM) were carried out under aerobic and continuous anaerobic conditions. An attempt was made to culture yeasts, mycoplasma, and virus from the biopsies of RAU, which were also tested for the presence of herpes virus antigen by the fluorescent antibody method. The predominant bacteria recovered in RAU were alpha-hemolytic streptococci, coagulase-negative staphylococci, and Neisseria. In EOU the main recoveries were alpha-hemolytic streptococci, Corynebacterium, Veillonella, Neisseria, and Haemophilus. In NOM alpha-hemolytic streptococci dominated the cultures. Yeasts were only cultured from one patient with RAU. No mycoplasmas or viruses were isolated, nor was herpes virus antigen demonstrated in any of the RAU specimens. The role of the microorganisms in the pathogenesis of RAU is discussed.

Adolescent↗
PubMed1976

Clinical, radiologic, and histopathologic aspects of 13 cases of nevoid basal cell carcinoma syndrome.

Thirteeen patients with the characteristic signs and symptoms of the nevoid basal cell carcinoma syndrome (NBS) are presented. It is suggested that the chromosomal anomalies sporadically reported have hardly any connection with the syndrome. The jaw cysts removed from the patients with NBS were clinically, radiologically, and histopathologically typical keratocysts with a high occurrence of epithelial islands and/or microcyts in the connective tissue of the capsule. The significantly higher occurrence of proliferative epithelial remnants in the connective tissue of the cyst wall may be an explanation of the high recurrence rate seen in patients with NBS and of the recurrence of some solitary keratocysts in patients without any signs or symptoms of NBS. In a follow-up period of 2 years, 85% of the patients with NBS showed recurrence. One-third of these patients did not show any recurrence at the 1-year follow-up. Therefore, a follow-up period of 2 years or more is mandatory in the care of patients with the nevoid basal cell carcinoma syndrome.

Adolescent↗
PubMed1976

Ultrastructure of epithelial lining of keratocysts in nevoid basal cell carcinoma syndrome.

The ultrastructure of the epithelial lining of 12 odontogenic keratocysts in nevoid basal cell carcinoma syndrome was investigated. The differences in fine structure between normal keratinizing squamous epithelium of skin or mucous membrane and keratocyst epithelium are discussed. It is demonstrated that separation of keratocyst epithelium from the underlying fibrous capsule is due to fragmentation and partial or complete disappearance of collagen in the juxtapithelial connective tissue compartment. Collagenolytic activity is suggested as a probably mechanism for this phenomenon.

Adolescent↗
PubMed1976

A leucocyte migration study on the cell-mediated immunity against adult human oral mucosa and streptococcal antigens in patients with recurrent aphthous stomatitis.

In vitro demonstration of cell-mediated immunity (CMI) against adult human oral mucosa antigen (AHOM) and streptococcal antigens was accomplished by means of the leucocyte migration test (LMT) in patients with recurrent aphthous stomatitis (RAS). If antigenic extracts of AHOM, Streptococcus sanguis strain 2A or Streptococcus pyogenes strain M5 were used in the LMT experiments, the distribution of migration indices (MI) over patients with RAS differed significantly from the distribution over the controls. In patients with other oral lesions, these MI-distributions did not differ significantly from those among the controls. Extracts of other tissues such as kidney and uterus tissues or of other bacterial antigens such as Brucella abortus and Escherichia coli did not reveal any significant differences between the LMT responses in RAS and controls. The present findings show that CIM against AHOM antigen and streptococcal antigens are features characteristic of RAS. Furthermore, the results indicate that common antigenic determinants might be shared by AHOM and streptococci.

Adolescent↗