Biomedical subjects

O E Idowu

Publications and source records attributed to O E Idowu.

7 recordsLinked to original sources

PubMed2006

Non-operative management of benign intracranial hypertension presenting with complete visual loss and deafness.

Benign intracranial hypertension (BIH) may lead to blindness and rarely deafness. We describe the case of a rapidly deteriorating 14-year-old African girl who presented with headaches associated with complete visual and hearing loss due to BIH. This was managed non-operatively with lumbar cerebrospinal fluid tap, weight reduction, nicotinic acid and acetazolamide. Response to treatment was quite dramatic with resolution of severe headaches and regaining of light perception 8 days after commencing treatment. By 3 months hearing recovered to normal and there was resolution of vision. This to the best of our knowledge is the first reported case of complete visual and hearing loss occurring in a patient with BIH, which was managed successfully non-operatively. When indicated, non-operative management is an effective treatment option even in malignant BIH.

Acetazolamide↗

PubMed2004

Surgical management of tuberculum sellae meningioma in a patient with a twin pregnancy: case report.

BACKGROUND: Meningioma in twin pregnancy is rare. The tumor has an accelerated growth during the pregnancy and may enlarge or become symptomatic during this period. This relationship makes management of patients with this tumor quite challenging. CASE DESCRIPTION: We describe a case of a rapidly deteriorating 35-year-old woman harboring an extensive tuberculum sellae meningioma who underwent craniotomy during the 24th week of pregnancy because of rapid deterioration. The surgical procedure and postoperative period were relatively uneventful. CONCLUSION: To the best of our knowledge, this is the first reported case of surgical management of a meningioma in a patient carrying a twin pregnancy (one missed abortus). When indicated, craniotomy is a safe and effective treatment option for huge frontobasal tumors during the second trimester of pregnancy.

Adult↗

PubMed2004

The jugular foramen -- a morphometric study.

The jugular foramen (JF) varies in shape and size from side to side in the same cranium, and in different crania, racial groups and sexes. Side dominance is also said to be common. The foramen's irregular shape, its formation by two bones and the numerous nerves and venous channels that pass through it further compound its anatomy. A morphometric study of 20 (40 JF) adult male Nigerian dry skulls was carried out. A bony bridge completely partitioned the JF in 3 (7.5%) of the JF. There was no tripartite JF. The JF mean length on the right and left were 13.90 mm (11.6-17.0 mm) and 14.11 mm (9.2-20.2 mm), while their widths measured 10.22 mm (6.8 -14.4 mm) and 9.57 mm (7.4-12.8 mm) on the right and left respectively. The mean JF area on the right was 437.49 mm (265.35-669.54 mm) and that on the left was 419.48 mm (276.46-634.60 mm). Side predominance of one of the JF appeared in 80% of cases. When present, the predominance of the right side was 55%, with 25% on the left. There was a difference in the length and width on each side but no significant difference in the length, width and area of the JF between the two sides. There was a positive correlation between skull width/ length and height/length ratio and JF area and length on each side. In conclusion, complete bony subdivision of the JF was not common among our study population and although the JF was generally larger on the right in our population, this is not statistically significant. A higher skull width/length and height/length ratio is associated with a greater JF length and area.

Adult↗

PubMed2003

Hip fractures in a tropical teaching hospital.

The pattern of hip fractures, treatment, outcome of treatment, and complications of forty-four consecutive patients treated over a five-year period were retrospectively studied. This represents 3.5% of the hospitalised patients in orthopaedic services. The male:female ratio was 1:1.3. Seventy percent of the fractures occurred in those over 65 years of age. The fractures were the result of low energy trauma in 81.8% of patients. Intracapsular (cervical) fractures accounted for 79.5% of the total cases. Only two patients had associated injuries on admission. Austin Moore hemiarthroplasty was the choice of hip replacement for intracapsular fractures, while ORIF (Open reduction and internal fixation using fixed angle blade plate) was done for patients with (extracapsular) trochanteric fractures. Anaesthesia (general or regional) was uneventful. Non-fatal pulmonary embolism occurred in one patient post-hemiarthroplasty while in the hospital. This study shows that hip fractures are not uncommon in our environment although far less common than what obtains in the Caucasians.

Adolescent↗

PubMed2002

Size, course, distribution and anomalies of the middle cerebral artery in adult Nigerians.

OBJECTIVE: To determine the size, course, distribution and anomalies of the middle cerebral artery in adult Nigerians. DESIGN: A retrospective study. SETTING: Department of pathology, University College Hospital, Ibadan between April and September 1999. SUBJECTS: One hundred middle cerebral arteries from patients' asymptomatic for central nervous system lesions, obtained at autopsy from fifty adult Nigerians were examined. RESULTS: The MCA arose as the wider of the two terminal branches of the internal carotid artery (ICA). Its mean diameter was 3.49 mm (CI = 3.39-3.59 mm), while the mean pre-division length was 15.43 mm (CI = 14.59-16.27 mm). In 92% of specimens, the first branches were perforators. The early branches were destined solely to the temporal lobe pole in most hemispheres (85%). In most specimens, (81%) the main trunk bifurcated while in 13% it trifurcated. One accessory MCA, and the early branches were given off before the perforators in two middle cerebral arteries, making an incidence of anomalies of 3%. There was no aneurysm. CONCLUSION: These results are similar to what has been described in the literature for Caucasians. It buttresses the assertion that anatomical anomalies of the MCA are rare. The rarity at autopsy of aneurysms of the MCA in asymptomatic Nigerian Africans is not explained by the gross morphology of this vessel.

Adult↗

PubMedDate not supplied

Traumatic dislocation of the hip joint--pattern and management in a tropical African population.

Traumatic dislocation of the hip is an orthopaedic emergency for which early reduction is indicated. This article describe our experience of the pattern and choice of management of traumatic dislocation of the hip joint in a tropical African population. Majority of the dislocation (87%) were Thompson and Epstein's grades I and II which were easily managed by closed reduction following the administration of titrated intravenous analgesic and intravenous diazepam. This treatment option is cheap and readily administrable to avoid undue delays in the management of this orthopaedic emergency. All the close reduction were carried out in the accident and emergency room except for one patient with bilateral posterior hip dislocation who had his reduction on the ward. Early diagnosis and treatment of traumatic hip dislocation are essential to reduce the morbidities that are commonly associated with delay in reduction.

Adolescent↗

PubMedDate not supplied

Biological therapy in cancer.

The current therapeutic modalities for the treatment of patients with cancer are surgery, radiotherapy, chemotherapy, immunotherapy and hormonal therapy. The spontaneous regression of advanced disease in immunogenic tumours and the discovery of several gene classes involved in carcinogenesis has opened new avenues for exploring the control of cellular growth in cancer by biological therapy. There is gradual and steady improvement and refinement in immunotherapy while gene manipulation is becoming easier. Though many ethical and technical obstacles remain, the rapid rate of advancement in recombinant deoxyribonucleic acid (DNA) technology may lead to a major breakthrough in gene therapy in the nearest future.

Biological Therapy↗