PubMed Health⌕ Search

Biomedical subjects

O E Kolesova

Publications and source records attributed to O E Kolesova.

At least 19 recordsLinked to original sources
PubMed2003

Effect of insulin on the rate of hydrogen peroxide generation in mitochondria.

We studied the effect of insulin on H2O2 generation by mitochondria in rat liver and heart. Insulin markedly increased the rate of H2O2 generation, which was realized via short-term activation of mitochondrial succinate dehydrogenase. In terms of the Michaelis-Menten equation describing the dependence of H2O2 generation by mitochondria on succinate concentration (succinate dehydrogenase substrate), insulin decreased the Michaelis-Menten constant and increased the maximum rate of H2O2 generation compared to the control.

Animals↗
PubMed2002

Key role of succinate dehydrogenase in insulin-induced inactivation of protein tyrosine phosphatases.

We studied the role of mitochondria in insulin-induced inactivation of protein tyrosine phosphatases in the liver. The mitochondrial respiratory chain is an insulin-sensitive source of H(2)O(2)that acts as a physiological inhibitor of protein tyrosine phosphatases. Succinate dehydrogenase plays a key role in insulin-stimulated generation of H(2)O(2)and inactivation of liver protein tyrosine phosphatases.

Animals↗
PubMed1994

[Use of UV-irradiated donor plasma in the treatment of destructive pancreatitis].

Donor plasma exposed to UV rays was included in the complex of measures for the treatment of diffuse pancreonecrosis with marked signs of enzyme toxemia and endogenous intoxication in 14 patients. The irradiation was conducted on an original device in which a [symbol: see text] lamp with a wave length of 253.6 nm was used as the source of radiation. Study of the dynamics of changes in the level of lipid peroxidation, alpha-tocopherol, trypsin, and lipase allows the conclusion that infusion of donor plasma exposed to UV radiation has a favorable effect on processes of detoxification of the organism.

Adult↗
PubMed1991

[The use of ultraviolet-irradiated plasma in the treatment of peritonitis].

Intravenous infusion of the one-group lyophilized donor plasma irradiated with ultraviolet rays was included in the complex treatment of 43 patients with acute purulent peritonitis. The species-specific composition of the microflora was studied in the different groups of patients according to the cause of peritonitis and the degree of microbial contamination of the purulent wounds in patients treated with and without ultraviolet plasma irradiation (UVPI). For prognosticating the course and outcome of the disease the authors used a complex of indices linked with the manifestation of neutrophil bactericidal activity and the level of exogenous intoxication. A positive effect of UVPI in the management of acute purulent appendicitis was noted, which was confirmed by clinical and microbiological tests.

Adolescent↗
PubMed1991

[Use of ribonuclease in multimodal treatment of acute pancreatitis].

The method of intraductal administration of ribonuclease as a therapeutic measure was developed on an experimental model of acute pancreatitis in albino rats. Morphological and biochemical examination showed that intraductal administration of ribonuclease in a dose of 0.5 mg produces a positive therapeutic effect, which allowed the method to be applied in complex treatment of 33 patients with various forms of acute pancreatitis. Administration of ribonuclease into the pancreatic duct relieved the attack of pain and reduced the level of lipo- and proteolytic enzymes in blood. No complications were encountered in endoscopic cannulation of the main pancreatic duct and subsequent administration of ribonuclease.

Acute Disease↗
PubMed1989

[Spastic torticollis].

Fifty-seven cases of spastic torticollis are reported, and its etiologic factors, including stressful situations, are analyzed. Plasma serotonin measurements have added new insight into pathogenetic mechanisms of the condition. The range of "reflex" spastic torticollis has been limited on the basis of biochemical and EMG findings. Fairly high incidence of attendant extrapyramidal symptoms and their polymorphism are pointed out, and, the need for a differential approach to the treatment of spastic torticollis being emphasized, a schedule of combined treatment, incorporating eglonyl and amitriptyline, is proposed for clonic-tonic torticollis.

Amitriptyline↗
PubMed1989

[Acid-base equilibrium of the blood during treatment using plasma UV-irradiation of chronic diseases of the liver and bile ducts with cholestasis].

Donor plasma irradiated by ultraviolet rays was administered intravenously to patients with choledocholithiasis, chronic hepatitis and liver cirrhosis. Parameters of the acid-base balance of arterialized capillary blood shifted to alkalosis, were normalized, and tension of carbon dioxide and oxygen in the blood increased to physiological values. Dynamic changes of the biochemical parameters demonstrated alleviation of manifestations of the cholestasis syndrome.

Acid-Base Equilibrium↗
PubMed1985

Adrenoreactivity of the circulatory system and of some metabolic processes induced by narcosis and surgical trauma.

Adrenal reactivity of the circulation and of several metabolic and regulatory systems, which had been induced by narcosis and surgical trauma, was studied on 50 mongrel dogs. Operative trauma (thoracotomy) done under thiopental sodium narcosis was accompanied with the moderately elevated adrenal reactivity of the circulation and essentially unchanged metabolic processes. Changes in the cardiac contractility and pump function induced by catecholamines are mediated through cardiac and vascular beta-adrenergic mechanism. These metabolic changes are determined by the state of adrenergic mechanisms. At the same time there is no distinct correlation between these changes and beta-adrenoreceptor state.

Animals↗
PubMed1981

[Structural and functional changes in the liver in chronic recurrent cholecystitis].

Destructive, inflammatory and sclerotic alterations of the hepatic tissue, increased content of lipid inclusions, lysosomes and microbodies in hepatocytes, vesiculation of the endoplasmic reticulum and depletion of ribosomal granules in it were revealed by morphological examinations of liver samples from the gall bladder bed from patients will rarely, frequently and continuously recurring chronic cholecystitis. A relationship between resorption of lipid structures, content of lysosomes and microbodies, and glycogen accumulation in hepatic cells was found. The destructive morphological changes correlated with reduced capacity of the liver to absorb radioactive label, an increase of alanine transaminase level in the blood, and decreased oxidative processes in the mitochondrial fraction of the liver. The results of the study attest to the involvement of the liver in the pathological process in accord with the rate of cholecystitis recurrency.

Biopsy↗