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Biomedical subjects

O E McClusky

Publications and source records attributed to O E McClusky.

5 recordsLinked to original sources
PubMed1984

HL-A 27 in Reiter's syndrome and psoriatic arthritis: a genetic factor in disease susceptibility and expression.

The role of HL-A antigens in determining predisposition and clinical expression of variant forms of spondylitis was examined in 52 patients. HL-A 27, an antigen significantly correlated with ankylosing spondylitis, was found in 19 (63 per cent) of 30 patients with Reiter's syndrome. In 14 patients with psoriatic arthritis, this antigen was present only in the six patients who had spondylitis. The presence of HL-A 27 in Reiter's syndrome was correlated with the presence of uveitis, severe constitutional manifestations, and a chronic or relapsing course. The presence of HL-A 27 is associated with a genetic predisposition to Reiter's syndrome and with certain similarities in clinical expression of the variant forms of spondylitis.

Arthritis↗
PubMed1976

Incomplete Reiter's syndrome: discriminating features and HL-A W27 in diagnosis.

Reiter's syndrome (nonspecific urethritis, conjunctivitis, and arthritis) may present with arthritis alone. There are, however, other discriminating clinical features that contribute to diagnosis. Additionally, the presence of HL-A W27 provides a new diagnostic aid. Thirteen patients were studied and support the validity of the concept of incomplete Reiter's syndrome. Peripheral arthritis was the presenting complaint in all, and none had urethritis or conjunctivitis. The majority were young white men. The arthritis was oligoarticular and asymmetric with lower extremity involvement predominantly. Heel pain was a prominent symptom in 10, with periostitis of other sites in 5, and "sausage digits" in 8. Mucocutaneous lesions occurred in 1 and significant weight loss in 6. Only 2 had sacro-illiitis. Chronicity has characterized the course in 12. HL-A W27 was present in 12 of 13. Additional data suggest that Reiter's syndrome may be one of the most common forms of inflammatory arthritis in young men.

Adolescent↗