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Biomedical subjects

O E Obasi

Publications and source records attributed to O E Obasi.

12 recordsLinked to original sources
PubMed1991

Pyoderma gangrenosum and malignant pyoderma in Nigeria.

Five patients (four black Nigerian males and one Polynesian) with pyoderma gangrenosum (PG) were seen between May 1974 and March 1984, at the Ahmadu Bello University Teaching Hospital, Kaduna, Nigeria. Their age range was 12-42 years (mean 25.6 years). The female expatriate Polynesian patient had PG localized to the upper back while the other four patients had severe and extensive PG lesions. Local cleansing and dressing of the ulcers combined with appropriate systemic antibiotics produced healing in two of these patients. The empirical addition of dapsone and rifampicin led to complete healing in two others, but only transient remission in one patient who, after 22 years of disease activity, died at home from an aggressive and accelerated form of the disease best described as 'malignant pyoderma' gangrenosum.

Adult↗
PubMed1991

Cutaneous leishmaniasis in Nigeria.

Twenty-one of 18,000 (0.1%) dermatology patients seen at the Ahmadu Bello University (ABU) Teaching Hospital, Kaduna, Nigeria, during the 9-year period October, 1979-August, 1988, had cutaneous leishmaniasis (CL). Their age range was 14 to 50 years (mean 28.7 years), with a peak at the 14- to 25-year age group. Eleven of the 21 patients (52%) were students in Government Colleges located within the leishmaniasis belt of Nigeria.

Adolescent↗
PubMed1989

Dermatophyte fungi in the Guinea Savannah region of Nigeria and the changing phase of dermatophytosis in Nigeria.

Approximately 8,000 patients with various skin diseases were seen at the Ahmadu Bello University Teaching Hospital, Kaduna, Nigeria between January 1983 and December 1986. 174 (2.2%) presented with features in which a clinical diagnosis of superficial fungal infection was made or suspected. 69 out of 190 (36.3%) of specimens taken from skin lesions or nails from these patients were mycologically positive. The fungi isolated were Trichophyton rubrum (24.6%), Tr. soudanense (13.0%), Candida albicans (5.8%) Hendersonula toruloidea (2.9%), Microsporum audouinii (1.5%) and Epidermophyton floccosum (1.5%); 34.8% of the specimens were positive on microscopy but failed to grow. Malassezia furfur was demonstrated in 15.9% of the 69 positive specimens.

Adolescent↗
PubMed1987

Bazex paraneoplastic acrokeratosis in prostate carcinoma.

We describe a patient in whom symmetrical acrokeratosis appeared 6 years before the diagnosis of metastatic carcinoma of the prostate causing paraplegia. The paraneoplastic dermatosis and paraplegia regressed following treatment with stilboestrol and topical applications of 2% salicylic acid in vaseline. To our knowledge, Bazex acrokeratosis has not been reported previously in association with carcinoma of the prostate.

Adenocarcinoma↗
PubMed1986

Cutaneous schistosomiasis in Nigeria. An update.

Two patients with schistosomiasis of the skin were seen at the Ahmadu Bello University Teaching Hospital, Kaduna, Northern Nigeria, between June 1978 and December 1980. The first case was not suspected on clinical grounds, but was diagnosed only after terminally-spined ova of Schistosoma haematobium were found in histological sections of the skin lesions. Both patients were successfully treated with niridazole (Ambilhar). These bring to eight the total number of cases of cutaneous schistosomiasis recorded in Nigeria in the past 40 years, four of which were in indigenous Nigerians. It seems that the high endemicity of the disease confers some degree of natural immunity to the indigenous population, making ectopic forms rare. Clinicians should be aware of the existence of cutaneous forms of the disease and of their excellent response to specific chemotherapy.

Antiparasitic Agents↗
PubMed1986

Psoriasis vulgaris in the Guinea Savanah region of Nigeria.

Psoriasis vulgaris is an uncommon skin disease among Nigerians. There were only 44 cases out of a total of about 5,250 skin patients (0.8%) seen during the 7-year period from 1977 to 1984 at the consultant skin clinic, Ahmadu Bello University Teaching Hospital, Kaduna, Nigeria. Males were predominant. The age range was 1 1/2 months to 65 years, with a mean age of 29.8 years. The peak incidence was in the 21-30-year group. Clinical features were the same as in Europeans, but morbidity was very low. Arthropathy and nail involvement were rare, comprising only 4.5 and 15.9% of cases, respectively.

Adolescent↗
PubMed1985

This is not leprosy but porphyria cutanea tarda.

Three cases of porphyria cutanea tarda (PCT) misdiagnosed as leprosy were seen between 1978 and 1984 at Kaduna, Nigeria. All three patients had been heavy drinkers of a native alcoholic beverage, "burukutu" as well as beer, for several years. Alcohol abstinence and oral chloroquine therapy produced satisfactory remission of the disease. This is believed to be the first report of cases of porphyria cutanea tarda from Nigeria.

Adult↗